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Total 5519 results found since Jan 2013.

Deciphering the pharmacological mechanism of the Chinese formula Huanglian-Jie-Du decoction in the treatment of ischemic stroke using a systems biology-based strategy
amp; Hong-jun Yang
Source: Acta Pharmacologica Sinica - June 3, 2015 Category: Drugs & Pharmacology Authors: Yan-qiong ZhangSong-song WangWei-liang ZhuYan MaFang-bo ZhangRi-xin LiangHai-yu XuHong-jun Yang Tags: Traditional Chinese Medicine Chinese herbal formula ischemic stroke Huanglian-Jie-Du decoction systems biology network pharmacology Source Type: research

Brain protection against ischemic stroke using choline as a new molecular bypass treatment
mp; Hai Wang
Source: Acta Pharmacologica Sinica - December 3, 2015 Category: Drugs & Pharmacology Authors: Xin JinRu-huan WangHui WangChao-liang LongHai Wang Tags: ischemic stroke pMCAO rats choline methyllycaconitine neovascularization α7 nicotinic acetylcholine receptor HIF-1α VEGF angiogenesis brain microvascular endothelial cells Source Type: research

Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke
Jing Jin & Min Huang
Source: Acta Pharmacologica Sinica - June 30, 2016 Category: Drugs & Pharmacology Authors: Rui LiuZi-yi ZhouYi-bei ChenJia-li LiWei-bang YuXin-meng ChenMin ZhaoYuan-qi ZhaoYe-feng CaiJing JinMin Huang Tags: clopidogrel resistance ischemic stroke genotype analysis SNPs CYP3A4*1G NR1I2 CYP2C19*2 P2RY12 pharmacogenomics Source Type: research

Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy
mp; Min Huang
Source: Acta Pharmacologica Sinica - November 1, 2016 Category: Drugs & Pharmacology Authors: Ling-ling Peng Yuan-qi Zhao Zi-yi Zhou Jing Jin Min Zhao Xin-meng Chen Ling-yan Chen Ye-feng Cai Jia-li Li Min Huang Tags: ischemic stroke aspirin resistance platelet activity MDR1 TBXA2R PLA2G7 PEAR1 genetic polymorphisms Source Type: research

Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF- κB inflammatory signaling pathway
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway Acta Pharmacologica Sinica 38, 1236 (September 2017). doi:10.1038/aps.2017.22 Authors: Ni Pan, Liu-yi Lu, Mei Li, Guo-hao Wang, Fang-yun Sun, Hong-shuo Sun, Xue-jun Wen, Jian-ding Cheng, Jian-wen Chen, Ji-yan Pang, Jie Liu, Yong-yuan Guan, Li-yan Zhao, Wen-liang Chen & Guan-lei Wang
Source: Acta Pharmacologica Sinica - September 1, 2017 Category: Drugs & Pharmacology Authors: Ni Pan Liu-yi Lu Mei Li Guo-hao Wang Fang-yun Sun Hong-shuo Sun Xue-jun Wen Jian-ding Cheng Jian-wen Chen Ji-yan Pang Jie Liu Yong-yuan Guan Li-yan Zhao Wen-liang Chen Guan-lei Wang Tags: xyloketal B stroke ischemic brain injury middle cerebral artery occlusion ROS TLR4 NF- κB Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Survivability of patients admitted for stroke in a primary stroke center, Penang, Malaysia: a retrospective 5-year study
CONCLUSION: The findings of the study are intended to encourage more non-stroke hospitals in Malaysia to increase their efforts in treating stroke patients, as early treatment can help reduce the severity of the stroke. With the incorporation of evidence-based data, this study also contributes to local data for comparison and improves the implementation of regularly prescribed stroke medication.PMID:37131240 | DOI:10.1186/s40360-023-00669-8
Source: BMC Pharmacology and Toxicology - May 2, 2023 Category: Drugs & Pharmacology Authors: Monica Danial Nurul Shahira Izwani Mohdradzi Amer Hayat Khan Alan Swee Hock Ch'ng Looi Irene Source Type: research

The role of stem cell factor and granulocyte-colony stimulating factor in treatment of stroke.
This article summarizes the discovery of new routes of treatment for acute and chronic stroke using two hematopoietic growth factors, stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF). In a study of acute stroke, SCF and G-CSF alone or in combination displays neuroprotective effects in an animal model of stroke. SCF appears to be the optimal treatment for acute stroke as the functional outcome is superior to G-CSF alone or in combination (SCF+G-CSF); however, SCF+G-CSF does show better functional recovery than G-CSF. In a chronic stroke study, the therapeutic effects of SCF and G-CSF alone or in comb...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research