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Condition: Rhabdomyolysis

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Total 128 results found since Jan 2013.

Heat Stroke Leading to Acute Liver Injury & Failure: A Case Series from the Acute Liver Failure Study Group
ConclusionsManagement of ALI and ALF secondary to heat stroke should focus on cooling protocols and supportive care, with consideration of liver transplantation in refractory patients.This article is protected by copyright. All rights reserved.
Source: Liver International - January 26, 2017 Category: Gastroenterology Authors: Brian C. Davis, Holly Tillman, Raymond T. Chung, R. Todd Stravitz, K. Rajender Reddy, Robert J. Fontana, Brendan McGuire, Timothy Davern, William M. Lee, Tags: Rapid Communication Source Type: research

Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury.
In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells. These changes were companied by increased HDAC6 expression in the cytoplasm of renal tubular cells. Administration of TA significantly reduced serum creatinine and blood urea nitrogen levels a...
Source: American Journal of Physiology. Renal Physiology - January 3, 2017 Category: Physiology Authors: Yingfeng S, Liuqing X, Jinhua T, Lu F, Shuchen M, Xiaoyan M, Jing N, Xiaoling P, Andong Q, Shougang Z, Na L Tags: Am J Physiol Renal Physiol Source Type: research

Heat stroke with bimodal rhabdomyolysis: a case report and review of the literature
ConclusionsPhysicians should pay special attention to the stress of rehabilitation exercises, which may cause collapsed muscles that are injured by severe heat stroke to repeatedly flare up.
Source: Journal of Intensive Care - November 30, 2016 Category: Intensive Care Source Type: research

Interpretation of the evidence for the efficacy and safety of statin therapy
Publication date: Available online 8 September 2016 Source:The Lancet Author(s): Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention...
Source: The Lancet - September 8, 2016 Category: Journals (General) Source Type: research

The phenotypic spectrum of fifty Czech m.3243A & gt;G carriers
Conclusions Sufficient knowledge of the timeline of the natural course of MELAS syndrome may improve the prediction and management of symptoms in patients with this mitochondrial disease.
Source: Molecular Genetics and Metabolism - July 20, 2016 Category: Genetics & Stem Cells Source Type: research

A cost-effectiveness analysis of over-the-counter statins.
CONCLUSIONS: With proper labeling and consumer education, it is highly likely that OTC statins would be cost-effective, as they significantly improve population health without large increases in healthcare costs. PMID: 27266585 [PubMed - in process]
Source: The American Journal of Managed Care - June 10, 2016 Category: Health Management Authors: Stomberg C, Albaugh M, Shiffman S, Sood N Tags: Am J Manag Care Source Type: research

The phenotypic spectrum of fifty Czech m.3243A>G carriers
Conclusions Sufficient knowledge of the timeline of the natural course of MELAS syndrome may improve the prediction and management of symptoms in patients with this mitochondrial disease.
Source: Molecular Genetics and Metabolism - June 6, 2016 Category: Genetics & Stem Cells Source Type: research

Hyperthermia and Severe Rhabdomyolysis From Synthetic Cannabinoids Am J Emerg Med 2016;34:121.e1-2. Doi: 10.1016/j.Ajem.2015.05.052. Epub 2015 Jun 12
We read with great interest the case report by Sweeney et al. [1] discussing severe hyperthermia and rhabdomyolysis following a reported exposure to a synthetic cannabinoid receptor agonist (SCRA). SCRA exposures, first reported in NYC in 2010, were at an all-time high in 2015 [2]. Confirmed cases of significant SCRA-associated acute kidney injury, stroke, and acute psychosis are reported [3,4].
Source: The American Journal of Emergency Medicine - May 10, 2016 Category: Emergency Medicine Authors: Mark Su, Larissa Laskowski, Robert S. Hoffman Tags: Correspondence Source Type: research

Letter in response to: Hyperthermia and severe rhabdomyolysis from synthetic cannabinoids. Am J Emerg Med 2016;34:121.e1–2. doi: 10.1016/j.ajem.2015.05.052. Epub 2015 Jun. 12
We read with great interest the case report by Sweeney et al. [1] discussing severe hyperthermia and rhabdomyolysis following a reported exposure to a synthetic cannabinoid receptor agonist (SCRA). SCRA exposures, first reported in NYC in 2010, were at an all-time high in 2015 [2]. Confirmed cases of significant SCRA-associated acute kidney injury, stroke and acute psychosis are reported [3,4].
Source: The American Journal of Emergency Medicine - May 10, 2016 Category: Emergency Medicine Authors: Mark Su, Larissa Laskowski, Robert S. Hoffman Tags: Correspondence Source Type: research

Comparative Effectiveness of Generic Atorvastatin and Lipitor(R) in Patients Hospitalized with an Acute Coronary Syndrome Health Services and Outcomes Research
Conclusions Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor® at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and health care plans without diminishing population clinical effectiveness.
Source: JAHA:Journal of the American Heart Association - April 18, 2016 Category: Cardiology Authors: Jackevicius, C. A., Tu, J. V., Krumholz, H. M., Austin, P. C., Ross, J. S., Stukel, T. A., Koh, M., Chong, A., Ko, D. T. Tags: Atrial Fibrillation, Quality and Outcomes Health Services and Outcomes Research Source Type: research

A rare autopsy case of traumatic rhabdomyolysis associated with intermittent assault
Rhabdomyolysis, or the dissolution of skeletal muscle, is characterized by the leakage of intramyocellular substances such as myoglobin, electrolytes, and other sarcoplasmic proteins into the circulation [1–3]. The development of rhabdomyolysis has many causes, including trauma, excessive muscular activity (e.g., exercises and seizures), prolonged immobilization, muscle ischemia, infection, excess body heat (e.g., heat stroke and malignant syndrome), metabolic and electrolyte disorders, drugs and toxins, and genetic defects [4–9].
Source: Legal Medicine - April 11, 2016 Category: Forensic Medicine Authors: Fumiko Chiba, Yohsuke Makino, Ayumi Motomura, Go Inokuchi, Namiko Ishii, Suguru Torimitsu, Yumi Hoshioka, Hiroko Abe, Rutsuko Yamaguchi, Mari Hashimoto, Ayaka Sakuma, Sayaka Nagasawa, Hisako Saito, Daisuke Yajima, Hirotaro Iwase Source Type: research

New drug 'effective' for those with intolerable statin side effects
Conclusion The main results of this study relate to the lipid-lowering effects of two alternative non-statin medications. However, it highlights the muscle-related adverse effects that can occur with statins. The study is carefully designed and has many strengths, including: a washout period between drugs to remove any residual effects double-blind design throughout so people didn't know what they were taking sufficient duration for each phase of the study (10 and 24 weeks) to allow effects to develop a good sample size – the researchers calculated beforehand how many people would need to be recruited to ena...
Source: NHS News Feed - April 4, 2016 Category: Consumer Health News Tags: Heart/lungs Medication Older people Source Type: news

Exertional heat stroke in a young military trainee: is it preventable?
Conclusion It is clear that heat stroke does occur in military trainees while preventive strategies are being practiced. It is important for those who provide healthcare to soldiers to provide proper advice on how to identify impending heat stroke prior to any exercises resulting in severe physical exertion. Further, treating physicians should educate all military trainees about preventive strategies.
Source: Military Medical Research - March 30, 2016 Category: Global & Universal Source Type: research

Challenging return to play decisions: heat stroke, exertional rhabdomyolysis, and exertional collapse associated with sickle cell trait - Asplund CA, O'Connor FG.
CONTEXT: Sports medicine providers frequently return athletes to play after sports-related injuries and conditions. Many of these conditions have guidelines or medical evidence to guide the decision-making process. Occasionally, however, sports medicine pr...
Source: SafetyLit - March 3, 2016 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news