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Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population-based longitudinal study.
DISCUSSION: AD and IS share risk/protective profiles, and SPFs seem to counteract the adverse effects of SRFs on both AD and IS. PMID: 33527694 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - February 3, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study.
CONCLUSION: The use of statins might be beneficial for the survival and ischemic stroke risk in patients with dementia in a dose-dependent manner. PMID: 33327915 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - December 15, 2020 Category: Neurology Authors: Bojana P, Hong X, Marta VL, Bengt W, Milica GK, Maria E, Sara GP Tags: Curr Alzheimer Res Source Type: research

Beta-blocker therapy and risk of vascular dementia: A population-based prospective study.
Abstract There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2, males 63.4%) followed up for 84,506 person-years. Dementia cases were retrieved from the Swedish National Patient Register and validated by review of medical records and neuroimaging data. We performed propensi...
Source: Vascular Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Holm H, Ricci F, Di Martino G, Bachus E, Nilsson ED, Ballerini P, Melander O, Hansson O, Nägga K, Magnusson M, Fedorowski A Tags: Vascul Pharmacol Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Editorial: Telomeres and Epigenetics in Endocrinology
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Dementia, Alzheimer's linked to stroke deaths
Researchers in Sweden have tied deaths from ischemic stroke to dementia and Alzheimer's disease, a study says.
Source: Health News - UPI.com - December 17, 2018 Category: Consumer Health News Source Type: news

Correlation of stroke and dementia with death: A study from the Swedish dementia registry
(Bentham Science Publishers) Patients who died of IS the most common type of dementia was vascular dementia while those died from other causes were most often diagnosed with Alzheimer's dementia (AD). Patients who died from IS and were registered in Riksstroke had higher MMSE score compared to other groups. Patients who died from IS took more cardiovascular medications. There were no differences in the use of antipsychotics, antidepressants, acetylcholinesterase inhibitors, memantine, anxiolytics, or hypnotics between the groups.
Source: EurekAlert! - Medicine and Health - December 14, 2018 Category: International Medicine & Public Health Source Type: news

Stroke as a cause of death in death certificates of patients with dementia: a cohort study from the Swedish Dementia Registry.
CONCLUSIONS: There was relatively high number of patients that died from IS in their death certificate but had not been registered in Riksstroke in the year before death. This creates concerns on the accuracy of death certificate stroke diagnoses, particularly for deaths taking place outside of hospitals. PMID: 30280666 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - October 2, 2018 Category: Neurology Authors: Subic A, Zupanic E, von Euler M, Norrving B, Cermakova P, Religa D, Winblad B, Kramberger MG, Eriksdotter M, Garcia-Ptacek S Tags: Curr Alzheimer Res Source Type: research

Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia
DiscussionThe use of AChEIs in people with dementia may be associated with reduced risk of ischemic stroke and death. These results call for a closer examination of the cardiovascular effects of AChEIs.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 10, 2018 Category: Geriatrics Source Type: research

Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia.
DISCUSSION: The use of AChEIs in people with dementia may be associated with reduced risk of ischemic stroke and death. These results call for a closer examination of the cardiovascular effects of AChEIs. PMID: 29706487 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - May 2, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research