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Cancer: Neuroblastoma
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Total 79 results found since Jan 2013.
Is air pollution a potential cause of neuronal injury?
CONCLUSION: Gluconeogenesis was induced in human neural cells exposed to fine particles (DEP), in association with cell damage and oxidative stress. These findings suggest that the pathogenesis of cerebrovascular injury due to fine particle pollutant exposure may proceed through derangements in gluconeogenic metabolism.
ABBREVIATIONS: DEP: diesel exhaust particles, ICA: intracranial atherosclerosis, ROS: reactive oxygen species.
PMID: 31099309 [PubMed - as supplied by publisher]
Source: Neurological Research - May 18, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Protective effect of gastrodin against methamphetamine-induced autophagy in human dopaminergic neuroblastoma SH-SY5Y cells via the AKT/mTOR signaling pathway
This study investigates whether METH induces autophagy in the human dopaminergic neuroblastoma cell line SH-SY5Y, then examines the neuroprotective effects of gastrodin against autophagy in METH-treated SH-SY5Y cells. The effects of METH on the protein expressions of autophagy-related genes (LC3B and Beclin-1) were evaluated with and without gastrodin. The presence of autophagosomes in the METH-induced treatment with and without gastrodin is revealed through transmission electron microscopy. Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotecti...
Source: Neuroscience Letters - May 24, 2019 Category: Neuroscience Source Type: research
Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.
Abstract
The neuropeptide orexin-A (OXA) has a neuroprotective effect, acting as an anti-apoptotic factor in response to multiple stimuli. Apoptosis induced by endoplasmic reticulum stress (ERS) underlies oxygen-glucose deprivation and reoxygenation (OGD/R)-induced cell damage, an in vitro model of ischemia/reperfusion injury. However, that OXA inhibits ERS-induced apoptosis in the OGD/R model has not been reported. In the present study, we investigated the neuroprotective effect of OXA (0.1 μM) on OGD/R-induced damage in the human neuroblastoma cell line SH-SY5Y. After OXA treatment following 4 h oxygen-gluc...
Source: Cellular Signalling - June 20, 2019 Category: Cytology Authors: Kong T, Qiu K, Liu M, Cheng B, Pan Y, Yang C, Chen J, Wang C Tags: Cell Signal Source Type: research
Levetiracetam, an antiepileptic drug has neuroprotective effects on intracranial hemorrhage injury
Publication date: Available online 11 February 2020Source: NeuroscienceAuthor(s): Takahiko Imai, Tomoki Sugiyama, Sena Iwata, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki HaraAbstractIntracranial hemorrhage (ICH) is a devastating disease that induces hematoma formation with poor neuronal outcome. Levetiracetam (LEV) has been approval for epilepsy seizures. In a previous study, LEV exerted protective effects on cerebral ischemia models; however, the detail effects and the influence of LEV on ICH are still unknown. The aim of this study was to investigate whether oral administration of LEV (50 or 150 mg/kg) has protective...
Source: Neuroscience - February 13, 2020 Category: Neuroscience Source Type: research
Akt and Src mediate the photocrosslinked fibroin-induced neural differentiation.
Neural transplantation is a promising modality for treatment of neurodegenerative diseases, traumatic brain injury and stroke. Biocompatible scaffolds with optimized properties improve the survival of transplanted neural cells and differentiation of progenitor cells into the desired types of neurons. Silk fibroin is a biocompatible material for tissue engineering. Here, we describe thin-film scaffolds based on photocrosslinked methacrylated silk fibroin (FBMA). These scaffolds exhibit an increased mechanical stiffness and improved water stability. Photocrosslinking of fibroin increased its rigidity from 25 to 480 kPa and...
Source: NeuroReport - June 9, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research
N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine attenuates oxygen-glucose deprivation and reoxygenation-induced cerebral ischemia-reperfusion injury via regulation of microRNAs.
Abstract
Cerebral ischemia-reperfusion injury is a common complication that occurs during stroke treatment. Increasingly, microRNAs have been found to participate in the modulation of neuron function; however, the role of microRNAs in cerebral ischemia-reperfusion injury remains unclear. We developed a mechanism of cerebral ischemia-reperfusion injury using a cellular model of oxygen-glucose deprivation and reoxygenation-induced injury in human neuroblastoma SH-SY5Y cells. We found that treatment of oxygen-glucose deprivation and reoxygenation promoted the apoptosis of SH-SY5Y cells. Analysis of microRNAs sequenci...
Source: Journal of Integrative Neuroscience - June 29, 2020 Category: Neuroscience Authors: Yang T, Wang D, Qu Y, Wang Y, Feng Y, Yang Y, Luo Q, Sun X, Yu G, He J, Sun Z, Zhu Y Tags: J Integr Neurosci Source Type: research
miR ‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
Mol Med Rep. 2020 Sep 07;:
Authors: Zhu L, Zhou X, Li S, Liu J, Yang J, Fan X, Zhou S
Abstract
Cerebral ischemia is a common cerebrovascular disease caused by the occlusion of a cerebral blood vessel. MicroRNAs (miRNAs/miRs) are emerging regulators of various human diseases, including cerebral ischemia. Upregulation of miR‑183‑5p has been reported to alleviate liver injury induced by ischemia‑reperfusion (I/R). However, the effect of miR‑183‑5p on cerebral ischemia injury remains unknown. The present study evalu...
Source: Molecular Medicine Reports - September 10, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
LncRNA FOXD3-AS1 knockdown protects against cerebral ischemia/reperfusion injury via miR-765/BCL2L13 axis.
CONCLUSIONS: We verified a critical signaling pathway of FOXD3-AS1/miR-765/BCL2L13 in regulating cerebral ischemia/reperfusion injury.
PMID: 33068927 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 14, 2020 Category: Drugs & Pharmacology Authors: Lu Y, Han Y, He J, Zhou B, Fang P, Li X Tags: Biomed Pharmacother Source Type: research
LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization.
Abstract
α7 nicotinic acetylcholine receptor (α7 nAChR) is an extensively validated target for several neurological and psychiatric conditions namely, dementia and schizophrenia, owing to its vital roles in cognition and sensorimotor gating. Positive allosteric modulation (PAM) of α7 nAChR represents an innovative approach to amplify endogenous cholinergic signaling in a temporally restricted manner in learning and memory centers of brain. α7 nAChR PAMs are anticipated to side-step burgeoning issues observed with several clinical-stage orthosteric α7 nAChR agonists, related to selectivity, tolerance/tachyphyl...
Source: European Journal of Pharmacology - October 27, 2020 Category: Drugs & Pharmacology Authors: Verma MK, Goel RN, Bokare AM, Dandekar MP, Koul S, Desai S, Tota S, Singh N, Nigade PB, Patil VB, Modi D, Mehta M, Gundu J, Walunj SS, Karche NP, Sinha N, Kamboj RK, Palle VP Tags: Eur J Pharmacol Source Type: research
Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
Bioorg Med Chem. 2021 Mar 24;38:116115. doi: 10.1016/j.bmc.2021.116115. Online ahead of print.ABSTRACTProlyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors. PHD inhibitors show promise for the treatment of diseases including anaemia, cardiovascular disease and stroke. In this work, a pharmacophore-based virtual high throughput screen was used to identify novel potential inhibitors of human PHD2. Two moderately potent new inhibitors were discovered, with IC50 values of 4 μM and 23 μM respectively...
Source: Bioorganic and Medicinal Chemistry - April 16, 2021 Category: Chemistry Authors: Nicole L Richardson Laura J O'Malley Daniel Weissberger Anthony Tumber Christopher J Schofield Renate Griffith Nicole M Jones Luke Hunter Source Type: research
Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis
Biomed Pharmacother. 2021 May 24;140:111696. doi: 10.1016/j.biopha.2021.111696. Online ahead of print.ABSTRACTGlutamate-induced neurotoxicity is one of the most important pathogenic mechanisms in neurological diseases and is widely used as an in vitro model for ischemic stroke. Senkyunolide I (SEI), an active constituent derived from traditional Chinese medicine Ligusticum chuanxiong Hort. and Angelica sinensis (Oliv.) Diels, has been shown to have beneficial effects against focal cerebral ischemia-reperfusion in rats. However, the mechanisms underlying SEI-mediated neuroprotection remain not well understood. Thus, we expl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2021 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jian-Xun Liu Norio Takagi Source Type: research
SIRT1/PGC-1 α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells
This study is designed to investigate the protective effect of MGF treatment in the setting of cerebral IRI and to elucidate the potential mechanisms. We first evaluated the toxicity of MGF and chose the safe concentrations for the following experiments. MGF exerted obvious neuroprotection against hypoxia/reoxygenation (HR)-induced injury, indicated by restored cell viability and cell morphology, decreased lactate dehydrogenase (LDH) release and reactive oxygen species generation. MGF also restored the protein expressions of SIRT1, PGC-1α, Nrf2, NQO1, HO-1, NRF1, UCP2, and Bcl2 down-regulated by HR treatment. However, SIR...
Source: European Journal of Pharmacology - June 11, 2021 Category: Drugs & Pharmacology Authors: Mengfan Chen Zheng Wang Wenying Zhou Chenxi Lu Ting Ji Wenwen Yang Zhenxiao Jin Ye Tian Wangrui Lei Songdi Wu Qi Fu Zhen Wu Xue Wu Mengzhen Han Minfeng Fang Yang Yang Source Type: research
