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Condition: Hemorrhagic Stroke
Cancer: Brain Cancers
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Total 297 results found since Jan 2013.
Tumor necrosis factor receptor ‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
This study was designed to explore changes of expression level and potential roles and mechanisms of TRAF6 in early brain injury (EBI) after SAH using a Sprague–Dawley rat model of SAH induced in 0.3 mL non‐heparinized autologous arterial blood injected into the pre‐chiasmatic cistern. First, compared with the sham group, we found that the expression levels of TRAF6 increased gradually and peaked at 24 h after SAH. Second, the results showed that application of TRAF6 over‐expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve...
Source: Journal of Neurochemistry - June 20, 2017 Category: Neuroscience Authors: Yang Dou, Haitao Shen, Dongxia Feng, Haiying Li, Xiaodi Tian, Jian Zhang, Zhong Wang, Gang Chen Tags: Original Article Source Type: research
Survival in Out-of-hospital Rapid Sequence Intubation of Non-Traumatic Brain Pathologies.
CONCLUSIONS: Non-traumatic brain pathologies are seven times more prevalent than traumatic brain injuries in patients that underwent out-of-hospital RSI in Victoria, Australia. Since the mechanisms through which RSI impacts mortality might differ between traumatic brain injuries and NTBP, and given that NTBP is very prevalent, it follows that the use of RSI in NTBP could be unsupported.
PMID: 28622071 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - June 19, 2017 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
Scalp acupuncture attenuates neurological deficits in a rat model of hemorrhagic stroke.
CONCLUSIONS: Scalp acupuncture could improve neurological deficits in a rat model of hemorrhagic stroke.
PMID: 28619309 [PubMed - in process]
Source: Complementary Therapies in Medicine - June 1, 2017 Category: Complementary Medicine Authors: Liu H, Sun X, Zou W, Leng M, Zhang B, Kang X, He T, Wang H Tags: Complement Ther Med Source Type: research
α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage.
This study aimed to evaluate whether α7 nicotinic acetylcholine receptor (α7nAChR) stimulation ameliorates neuroinflammation after ICH. Male CD-1 mice and Sprague-Dawley were subjected to intracerebral injection of autologous blood or bacterial collagenase. ICH animals received either α7nAChR agonist PHA-543613 alone or combined with α7nAChR antagonist methyllycaconitine (MLA) or Janus kinase 2 (JAK2) antagonist AG490. Neurobehavioral deficits were evaluated at 24 hours, 72 hours, and 10 weeks after ICH induction. Perihematomal expressions of JAK2, signal transducer and activator of transcription 3 (STAT3), tumor necro...
Source: Biomed Res - May 24, 2017 Category: Research Authors: Krafft PR, McBride D, Rolland WB, Lekic T, Flores JJ, Zhang JH Tags: Biomed Res Int Source Type: research
TRAF6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
This study was designed to explore changes of expression level and potential roles and mechanisms of TRAF6 in early brain injury (EBI) after SAH by using a Sprague–Dawley rat model of SAH induced in 0.3 ml non‐heparinized autologous arterial blood injected into the prechiasmatic cistern. First, compared with the sham group, we found that the expression levels of TRAF6 increased gradually and peaked at 24 h after SAH. Second, the results showed that application of TRAF6 overexpression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI ...
Source: Journal of Neurochemistry - May 24, 2017 Category: Neurology Authors: Yang Dou, Haitao Shen, Dongxia Feng, Haiying Li, Xiaodi Tian, Jian Zhang, Zhong Wang, Gang Chen Tags: Original Article Source Type: research
Keeping up with Amanda: Life after brain surgery
In most ways, Amanda LePage is just like any other rambunctious fourth grader. She loves school, dance class, playing basketball and keeping up with her twin sister Macy and older brother Nathan. Sometimes it just takes her a little longer to do these everyday things. That’s because Amanda has been through a lot in her short nine years.
Amanda was just 5 months old when she was brought by helicopter to Boston Children’s Hospital for a hemorrhage in her brain from an intracranial aneurysm, a type of vascular malformation. Despite long odds, Amanda survived two life-saving brain surgeries and a massive stroke that left ...
Source: Thrive, Children's Hospital Boston - May 22, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories brain aneurysm Dr. Caroline Robson Dr. Craig McClain Dr. Edward Smith Dr. Peter Manley Hydrocephalus low-grade glioma pediatric stroke Source Type: news
Primary Angiitis of the Central Nervous System Clinical Sciences
Conclusions—Adult primary angiitis of the central nervous system is a heterogenous disease, with multiterritorial, distal, and bilateral acute stroke being the most common pattern of parenchymal lesions found on magnetic resonance imaging. Our findings suggest a higher than previously thought prevalence of hemorrhagic transformation and other hemorrhagic manifestations.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Gregoire Boulouis, Hubert de Boysson, Mathieu Zuber, Loic Guillevin, Eric Meary, Vincent Costalat, Christian Pagnoux, Olivier Naggara Tags: Imaging, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Rates and Predictors of 1 year of Readmission with Seizures in Patients with Stroke and Stroke Subtypes: Analysis of a National Cohort of 557,033 Stroke Patients (P2.245)
Conclusions:Rate readmission of seizure after stroke within first year is low and there may be residual confounding by severity. Our findings do not support a need for routine prophylactic anti-epileptic drug use after stroke.Disclosure: Dr. Chaudhry has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Afzal has nothing to disclose. Dr. Gheith has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Safdar has nothing to disclose. Dr. Kassab has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chaudhry, B., Chaudhry, S., Afzal, M.-R., Gheith, T., Gu, S., Saeed, A., Safdar, A., Kassab, M., Qureshi, A. Tags: Epilepsy and Clinical Neurophysiology: Clinical Epilepsy II Source Type: research
Giant-Cell Arteritis Presenting as Isolated Bilateral CN-VI Palsies: A Rare Case Report of a 65 Year Male. (P2.378)
Conclusions:GCA is the most prevalent systemic vasculitis in the elderly. It can present with a wide variety of symptoms ranging from fatigue, headache, visual loss, and even stroke. However as noted in this case, isolated CN-VI palsy can be a very rare, early manifestation of GCA. As GCA responds well to corticosteroid therapy, prompt diagnosis and treatment is critical to prevent and/or limit neurologic sequelae. As highlighted by this case, in the event of recurrent incidents and absence of other diagnosis; GCA should be considered even if headache is absent.Disclosure: Dr. Lunagariya has nothing to disclose. Dr. Patel ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lunagariya, A., Patel, U., Kotadiya, F., Wilson, C. Tags: CNS Inflammatory Diseases and Differential Diagnosis II Source Type: research
Nico wins CE Mark for BrainPath
Nico Corp said today it won CE Mark approval in the European Union for its BrainPath neurosurgery access device.
The BrainPath system uses a shunt and specially designed instrumentation to give surgeons access to the subcortical section of the brain.
“Gaining CE Mark approval for BrainPath is our first step in answering increasing global interest in a systems approach to subcortical brain surgery using a standardized approach. We intend to take a planned approach to global expansion and look forward to making a positive difference in the worldwide brain tumor and stroke incidence rate,” CEO Jim Pearson said i...
Source: Mass Device - April 3, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Neurological Regulatory/Compliance Surgical Nico Corp. Source Type: news
Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury
Conclusion Increased serum MIF concentrations have close relation to inflammation, trauma severity and clinical outcomes, substantializing MIF as a good prognostic biomarker after TBI.
Source: Clinica Chimica Acta - March 31, 2017 Category: Laboratory Medicine Source Type: research
Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury.
CONCLUSION: Increased serum MIF concentrations have close relation to inflammation, trauma severity and clinical outcomes, substantializing MIF as a good prognostic biomarker after TBI.
PMID: 28366792 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 30, 2017 Category: Chemistry Authors: Yang DB, Yu WH, Dong XQ, Zhang ZY, Du Q, Zhu Q, Che ZH, Wang H, Shen YF, Jiang L Tags: Clin Chim Acta Source Type: research
A case of acute subdural hematoma due to bleeding from metastatic chondrosarcoma of the skull.
CONCLUSION: In the event of subdural invasion of a metastatic lesion, intratumoral hemorrhage may induce acute SDH, as in the present case. Similar to our case, most previous reports of intracranial chondrosarcoma hemorrhage have had an unclear etiology. Despite the rarity of this event, a patient with a history of malignancy presenting with nontraumatic acute SDH should be examined for the intratumoral hemorrhage of skull metastasis in the differential diagnosis.
PMID: 28303203 [PubMed - in process]
Source: Surgical Neurology International - March 19, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Pinocembrin Protects Hemorrhagic Brain Primarily by Inhibiting Toll-like Receptor 4 and Reducing M1 Phenotype Microglia
In this study, we examined the efficacy of pinocembrin in an ICH model, and further examined its effect on microglial activation and polarization. In vivo, pinocembrin dose-dependently reduced lesion volume by ∼47.5% and reduced neurologic deficits of mice at 72 h after collagenase-induced ICH. The optimal dose of pinocembrin (5 mg/kg) suppressed microglial activation as evidenced by decreases in CD68-positive microglia and reduced proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. Pinocembrin also reduced the number of classically activated M1-like microglia without affecting M2-li...
Source: Brain, Behavior, and Immunity - December 20, 2016 Category: Neurology Source Type: research
Pinocembrin Protects Hemorrhagic Brain Primarily by Inhibiting Toll-like Receptor 4 and Reducing M1 Phenotype Microglia.
In this study, we examined the efficacy of pinocembrin in an ICH model, and further examined its effect on microglial activation and polarization. In vivo, pinocembrin dose-dependently reduced lesion volume by ∼47.5% and reduced neurologic deficits of mice at 72 h after collagenase-induced ICH. The optimal dose of pinocembrin (5 mg/kg) suppressed microglial activation as evidenced by decreases in CD68-positive microglia and reduced proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. Pinocembrin also reduced the number of classically activated M1-like microglia without affecting M2-li...
Source: Brain, Behavior, and Immunity - December 18, 2016 Category: Neurology Authors: Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, Wan J, Zhu W, Wang J Tags: Brain Behav Immun Source Type: research
