Filtered By:
Cancer: Primary CNS Lymphoma

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 41 results found since Jan 2013.

A stroke mimic; focal neurological deficits in benign hereditary chorea?
Conclusion This case highlights the difficulties in assessing patients with new focal neurological symptoms in the presence of known, pre existing, neurological disease. It also serves to highlight how often erroneously progressive weakness is mislabelled as a ‘stroke’. Neurologists working together with acute physicians in liaison posts in MAU, provides a unique opportunity to improve overall recognition of neurological disease, and for patients potentially provides a more timely diagnostic work–up and the opportunity for early treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Maw, K., Johnston, J., Rowntree, C., Kalhan, A. Tags: Immunology (including allergy), Headache (including migraine), Movement disorders (other than Parkinsons), Neurooncology, Pain (neurology), Stroke, CNS cancer, Neuropathology, Radiology, Surgical diagnostic tests, Surgical oncology Association of Britis Source Type: research

Diagnostic Yield and Safety of Brain Biopsy for Suspected Primary Central Nervous System Angiitis Brief Reports
Conclusions— Brain biopsy leads to pathological confirmation of vasculitis in a minority of suspected PACNS cases but alternative diagnoses are often identified. Importantly, rare but meaningful complications may occur.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Torres, J., Loomis, C., Cucchiara, B., Smith, M., Messe, S. Tags: Cerebrovascular Disease/Stroke Brief Reports Source Type: research

The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation
Conclusion: These results suggest intelectin-1 promotes angiogenesis, inhibits oxidative stress and reduces apoptosis by stimulating the Akt-eNOS signaling pathway in response to ischemia in vitro. Introduction Stroke is a main reason of human neurological disability, ischemic stroke (IS) accounts for almost 80–90% of all strokes. IS occurs after a cerebral blood flow disruption, leading to cellular death and tissue damage by restricting glucose and oxygen supplies (1). Ischemic vascular diseases cause substantial vascular valve and vascular endothelial cell injuries, eventually damaging the surrounding tis...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Subclinical Atherosclerosis in Primary Sj ögren's Syndrome: Does Inflammation Matter?
Conclusions The markers of endothelial activation and damage and of chronic inflammation investigated until now failed to result predictors of subclinical atherosclerosis or to be associated with increased risk of CV events in SS patients. This may suggest that other mechanisms are implicated with increased prevalence of subclinical atherosclerosis in SS or that these biomarkers exert a different mechanism in the pathogenesis of endothelial damage and in the induction of atherosclerosis. Surely, the relationship between the disease itself and inflammatory and immune dysfunction factors is quite complex and still to be cla...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL
Conclusions: This study showed that USPIO-enhanced brain MRI can be useful in the diagnosis of CNS inflammatory disorders and lymphoma, and is also useful for patients with renal compromise at risk of nephrogenic systemic fibrosis who are unable to receive GBCA.
Source: Neurology - July 15, 2013 Category: Neurology Authors: Farrell, B. T., Hamilton, B. E., Dosa, E., Rimely, E., Nasseri, M., Gahramanov, S., Lacy, C. A., Frenkel, E. P., Doolittle, N. D., Jacobs, P. M., Neuwelt, E. A. Tags: MRI, All Cerebrovascular disease/Stroke, All Oncology ARTICLE Source Type: research

Neuroimaging in Central Nervous System Lymphoma
Primary central nervous system lymphoma (PCNSL) is a rare aggressive high-grade type of extranodal lymphoma. PCNSL can have a variable imaging appearance and can mimic other brain disorders such as encephalitis, demyelination, and stroke. In addition to PCNSL, the CNS can be secondarily involved by systemic lymphoma. Computed tomography and conventional MRI are the initial imaging modalities to evaluate these lesions. Recently, however, advanced MRI techniques are more often used in an effort to narrow the differential diagnosis and potentially inform diagnostic and therapeutic decisions.
Source: Hematology/Oncology Clinics of North America - July 19, 2016 Category: Cancer & Oncology Authors: Seyed Ali Nabavizadeh, Arastoo Vossough, Mehrdad Hajmomenian, Reza Assadsangabi, Suyash Mohan Source Type: research

OS5.8 Intravascular lymphoma affecting the central nervous system: features and outcomes in a case series of the Primary CNS Lymphoma Collaborative Group (IPCG)
We present a retrospective case series of 65 adults with IVL from 14 cancer centers in 6 countries. IVL was restricted to the CNS in 29 cases, with a mean age of 60 years and 91% of patients having neurological deficits at the time of diagnosis. There was a mean diagnostic delay of 20 weeks after presentation of stroke-like symptoms or myelopathy. Ninety-three percent had a poor functional status with an Eastern Cooperative Oncology Group (ECOG) performance status ≥2. Serum LDH was elevated in 87% of patients with no correlation with treatment outcome. Frontline treatment with intravenous high-dose methotrexate-bas...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Zukas, A. M., Bennani, N., Chou, C., Johnston, P., ONeill, B., Nijland, M., Batchelor, T., Nayak, L., Mrugala, M., Schiff, D. Tags: OS5 Glioma: Clinical Source Type: research

Rare-39. intravascular lymphoma affecting the central nervous system: features and outcomes in a case series of the primary cns lymphoma collaborative group (ipcg)
We present a retrospective case series of 72 adults with IVL from 16 cancer centers in 6 countries. IVL was present in the CNS in 55 cases, with a mean age of 61.6 years and more than 90% of patients having neurological deficits at the time of diagnosis. There was a mean diagnostic delay of 20 weeks after presentation of stroke-like symptoms or myelopathy. Eighty-five percent had a poor functional status with an Eastern Cooperative Oncology Group (ECOG) performance status ≥2 with another eight percent diagnosed post-mortem. Serum LDH was elevated in 87% of available patients with no correlation with treatment outco...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Zukas, A., Bennani, N., Chou, C., Johnston, P., ONeill, B. P., Nijland, M., Batchelor, T., Nayak, L., Mrugala, M., Low, J., Omuro, A., Ferreri, A., Nishikawa, R., Mishima, K., Fox, C., Wilson, W., Houillier, C., Chamberlain, M., Schiff, D. Tags: RARE TUMORS Source Type: research

Enlargement of deep medullary veins during the early clinical course of Sturge-Weber syndrome
We report a retrospective case series of patients with relapsed and refractory CNS lymphoma treated with ibrutinib.
Source: Neurology - December 25, 2016 Category: Neurology Authors: Pilli, V. K., Chugani, H. T., Juhasz, C. Tags: MRI, PET, Other cerebrovascular disease/ Stroke, Developmental disorders CLINICAL/SCIENTIFIC NOTES Source Type: research

Cardiovascular disease incidence in adolescent and young adult cancer survivors: a retrospective cohort study
ConclusionWhile cancer therapies are known to increase the risk of CVD, this study additionally shows that CVD risk varies by sociodemographic factors.Implications for cancer survivorsThe identification and mitigation of CVD risk factors in these subgroups may improve long-term patient outcomes.
Source: Journal of Cancer Survivorship - February 9, 2018 Category: Cancer & Oncology Source Type: research

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis
Conclusion Recent advances in research on HTLV-1 provide better understanding of the molecular pathogenesis and mechanisms of HAM/TSP, and several clinical trials of novel therapies for patients with HAM/TSP have been initiated. However, long-term improvement of motor disability and quality of life still have not been achieved in HAM/TSP patients, and the clinical management remains challenging. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis....
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research