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Total 2156 results found since Jan 2013.

Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents
Fitoterapia. 2022 Dec 20:105398. doi: 10.1016/j.fitote.2022.105398. Online ahead of print.ABSTRACTPiper longum has a specific aroma and spicy taste. In addition to edible value, current studies have shown that piper longum also has pharmacological activities such as anti-platelet aggregation, anti-inflammation, anti-cancer, anti-diabetes and anti-depression. Piperlongumine is an alkaloid isolated from Piper longum. Based on our previous studies, four Piperlongumine analogs were synthesized, and their anti-platelet aggregation activities were evaluated. Among them, compound 8 has the strongest anti-platelet aggregation acti...
Source: Fitoterapia - December 23, 2022 Category: Biochemistry Authors: Tan Lijuan Cao Xiaolu Wan Xin He Yuying Lan Xi Yang Xiliang Wang Ting Min Zhenli Zou Yu Source Type: research

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke
ConclusionThis systematic analysis not only helps in the understanding of the changes in the gene expression profiles of both the brain and skull with ischemic injury but also reveals the association of the tumor immune microenvironment and cell death with ischemic stroke.
Source: Frontiers in Immunology - December 20, 2022 Category: Allergy & Immunology Source Type: research

Cognitive impairment, anxiety and depression: a map of Cochrane evidence relevant to rehabilitation for people with post COVID-19 condition
CONCLUSIONS: These results are the first step of indirect evidence able to generate helpful hypotheses for clinical practice and future research. They served as the basis for the three recommendations on treatments for these PCC symptoms published in the current WHO Guidelines for clinical practice.PMID:36534008 | DOI:10.23736/S1973-9087.22.07813-3
Source: European Journal of Physical and Rehabilitation Medicine - December 19, 2022 Category: Rehabilitation Authors: Claudio Cordani Vanessa M Young Chiara Arienti Stefano G Lazzarini Matteo J Del Furia Stefano Negrini Carlotte Kiekens Source Type: research

IJERPH, Vol. 19, Pages 16741: 1000 Days: The & ldquo;WeCare Generation & rdquo; Program & mdash;The Ultimate Model for Improving Human Mental Health and Economics: The Study Protocol
Discussion: An overall rate of return on investment (ROI) statistically significant 13.0% per annum with an associated benefit/cost ratio (BCR) of 6.3 is expected as the primary outcome of the “WeCare Generation” program. Our proposed model predicts a new medical paradigm aiming to empower new generations, with a strong return on economy and health.
Source: International Journal of Environmental Research and Public Health - December 13, 2022 Category: Environmental Health Authors: Orlando Uccellini Andrea Benlodi Emanuele Caroppo Loredana Cena Gianluca Esposito Isabel Fernandez Maria Ghazanfar Antonio Imbasciati Francesco Longo Marianna Mazza Giuseppe Marano Renata Nacinovich Antonio Pignatto Arthur Rolnick Marco Trivelli Elena Spa Tags: Article Source Type: research

What It ’s Like to Live With Stiff Person Syndrome
twIn an emotional social-media video posted Dec. 8, singer Celine Dion informed fans that she has been diagnosed with a rare neurological disease called stiff person syndrome. A diagnosis wasn’t easy or straightforward. “I’ve been dealing with problems with my health for a long time…we now know this is what’s been causing all of the spasms that I’ve been having,” said Dion, who is 54. Here’s what to know about the condition and what it feels like. What is stiff person syndrome? According to the National Institute of Neurological Disorders and Stroke, stiff person syndrome has...
Source: TIME: Health - December 9, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Disease healthscienceclimate Source Type: news

The final puff: Can New Zealand quit smoking for good?
Smoking kills. Ayesha Verrall has seen it up close. As a young resident physician in New Zealand’s public hospitals in the 2000s, Verrall watched smokers come into the emergency ward every night, struggling to breathe with their damaged lungs. Later, as an infectious disease specialist, she saw how smoking exacerbated illness in individuals diagnosed with tuberculosis and HIV/AIDS. She would tell them: “The best thing you can do to promote your health, other than take the pills, is to quit smoking.” Verrall is still urging citizens to give up cigarettes—no longer just one by one, but by the thousands. As New...
Source: ScienceNOW - December 9, 2022 Category: Science Source Type: news