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Cancer: Brain Cancers
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Total 2156 results found since Jan 2013.
Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research
Billions With Nutrition Deficiency!?
Almost no one gets enough selenium. Officially, at least a billion — with a B — people have a selenium deficiency.1
But I suspect the numbers are much higher than that.
You can’t get enough selenium from food alone anymore. That’s true even if you eat a healthy, varied diet. And you can thank Big Agra for that.
With their harsh pesticides, synthetic fertilizers, and single-crop strategy, these massive farms have stripped the nutrients out of the soil. No nutrients in the soil mean no nutrients in the food.
All of this makes it difficult — if not impossible — to get even some of the daily selenium you need to ...
Source: Al Sears, MD Natural Remedies - May 15, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Nutrition Source Type: news
A protocol based on Hypotension probability indicator vs. standard care to prevent intraoperative hypotension during supratentorial brain surgery: a prospective randomized pilot trial
CONCLUSIONS: In this pilot trial, the HPI-based protocol decreased the incidence of hypotension during the anesthesia maintenance but non-significant trends among secondary outcomes were also documented. Larger trials are needed to confirm our findings.PMID:37158627 | DOI:10.23736/S0375-9393.23.17197-5
Source: Minerva Anestesiologica - May 9, 2023 Category: Anesthesiology Authors: Jiri Pouska Jakub Kletecka Jan Zatloukal Vaclav Cerveny Jan Benes Source Type: research
Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke
We describe the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, we summarize the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS to provide new directions and ideas for the treatment of ischemic brain injury.PMID:37156641 | DOI:10.1002/jnr.25200
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Juan Gao Jifei Liu Yonghong Li Junxi Liu He Wang Miao Chai Ying Dong Zhenchang Zhang Gang Su Manxia Wang Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case –control and cross-sectional analysis
ConclusionsStroke prevalence is increased in long-surviving PBT patients treated with cranial RT.Implications for cancer survivorsCV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.
Source: Journal of Cancer Survivorship - May 5, 2023 Category: Cancer & Oncology Source Type: research
Late-onset vascular complications of radiotherapy for primary brain tumors: a case-control and cross-sectional analysis
CONCLUSIONS: Stroke prevalence is increased in long-surviving PBT patients treated with cranial RT.IMPLICATIONS FOR CANCER SURVIVORS: CV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.PMID:37142871 | DOI:10.1007/s11764-023-01350-z
Source: Cancer Control - May 4, 2023 Category: Cancer & Oncology Authors: Mar ía-José Ibáñez-Juliá Alberto Picca Delphine Leclercq Giulia Berzero Julian Jacob Lo ïc Feuvret Charlotte Rosso Cristina Birzu Agusti Alentorn Marc Sanson Camille Tafani Flavie Bompaire Luis Bataller Kh ê Hoang-Xuan Jean-Yves Delattre Dimitri Ps Source Type: research
Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors
Neurotox Res. 2023 May 2. doi: 10.1007/s12640-023-00644-5. Online ahead of print.ABSTRACTStroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of deaths worldwide each year. Since currently available therapies are insufficient, there is an urgent need for novel neuroprotective strategies to address the effects of cerebrovascular accidents. One such recent approach is based on the neuroprotective properties of estrogen receptors (ERs). However, activation of ERs by estrogens may contribute to the development of endometriosis or hormone-dependent cancers. Therefore, in this study, we util...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Bernadeta A Pietrzak Agnieszka Wnuk Karolina Przepi órska Andrzej Łach Ma łgorzata Kajta Source Type: research
U.S. Adult Smoking Rate Hits New All-Time Low
NEW YORK — U.S. cigarette smoking dropped to another all-time low last year, with 1 in 9 adults saying they were current smokers, according to government survey data released Thursday. Meanwhile, electronic cigarette use rose, to about 1 in 17 adults.
The preliminary findings from the Centers for Disease Control and Prevention are based on survey responses from more than 27,000 adults.
Cigarette smoking is a risk factor for lung cancer, heart disease, and stroke, and it’s long been considered the leading cause of preventable death.
In the mid-1960s, 42% of U.S. adults were smokers. The rate has been gradually d...
Source: TIME: Health - April 27, 2023 Category: Consumer Health News Authors: Mike Stobbe/AP Tags: Uncategorized Addiction healthscienceclimate wire Source Type: news
Loading Intracranial Drug-Eluting Reservoirs Across the Blood –Brain Barrier With Focused Ultrasound
Efficient, sustained and long-term delivery of therapeutics to the brain remains an important challenge to treatment of diseases such as brain cancer, stroke and neurodegenerative disease. Focused ultrasound can assist movement of drugs into the brain, but frequent and long-term use has remained impractical. Single-use intracranial drug-eluting depots show promise but are limited for the treatment of chronic diseases as they cannot be refilled non-invasively. Refillable drug-eluting depots could serve as a long-term solution, but refilling is hindered by the blood –brain barrier (BBB), which prevents drug refills from accessing the brain.
Source: Ultrasound in Medicine and Biology - April 27, 2023 Category: Radiology Authors: Christopher T. Moody, Phillip G. Durham, Paul A. Dayton, Yevgeny Brudno Tags: Technical Note Source Type: research
Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation
CONCLUSION: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.PMID:37096314 | DOI:10.3346/jkms.2023.38.e159
Source: Cancer Control - April 25, 2023 Category: Cancer & Oncology Authors: Jaelim Cho Heeseon Jang Young Noh Seung-Koo Lee Sang-Baek Koh Sun-Young Kim Changsoo Kim Source Type: research
Promoted Generation of T Helper 1-Like Regulatory T Cells After Transient Middle Cerebral Artery Occlusion in Type-2 Diabetic Mice
CONCLUSION: The generation of Th1-like Tregs was promoted in the brains of type 2 diabetic mice after stroke. Our study reveals significant Treg plasticity in diabetic stroke.Abbreviations: Foxp3: forkhead box P3; IFN-γ: interferon-γ; IL-10: interleukin-10; IL-12: interleukin-12; MCAO: middle cerebral artery occlusion; PBS: phosphate-buffered saline; STAT1: Signal transducer and activator of transcription 1; STAT5: Signal transducer and activator of transcription 1; T-bet: T-box expressed in T cells; TGF-β: transforming growth factor-β; Th1: T helper 1; TNF-α: tumor necrosis factor-α; Tregs: regulatory T cells. Foxp3...
Source: Immunological Investigations - April 19, 2023 Category: Allergy & Immunology Authors: Lei Jian Yanqi Hu Mingjie Gao Long Shu Source Type: research
