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Total 5439 results found since Jan 2013.
Unripe fruits of Litchi chinensis (Gaertn.) Sonn: An overview of its toxicity
Ann Pharm Fr. 2023 Jul 11:S0003-4509(23)00073-1. doi: 10.1016/j.pharma.2023.07.004. Online ahead of print.ABSTRACTLitchi (Litchi chinensis) is a widely consumed fruit that has been used in many food and health-promoting products worldwide. Litchi is a good source of nutrients including vitamin and minerals, dietary fibers, proteins, and carbohydrates. Of note, several studies have reported that the constituents of litchi fruits elicit antioxidant properties and help to maintain blood pressure, and reduce the risk of stroke and heart attack. An unclearly explained outbreak occurred in June 2019 in Muzaffarpur (Bihar), India...
Source: Annales Pharmaceutiques Francaises - July 13, 2023 Category: Drugs & Pharmacology Authors: Rajan Logesh Niranjan Das Gobi Sellappan Dariusz Piesik Arijit Mondal Source Type: research
The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation
Biomed Pharmacother. 2023 Jul 10;165:115141. doi: 10.1016/j.biopha.2023.115141. Online ahead of print.ABSTRACTIt is widely known that ischemic stroke is the prominent cause of death and disability. To date, neuroinflammation following ischemic stroke represents a complex event, which is an essential process and affects the prognosis of both experimental stroke animals and stroke patients. Intense neuroinflammation occurring during the acute phase of stroke contributes to neuronal injury, BBB breakdown, and worse neurological outcomes. Inhibition of neuroinflammation may be a promising target in the development of new thera...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 12, 2023 Category: Drugs & Pharmacology Authors: Weizhuo Lu Zhiwu Chen Jiyue Wen Source Type: research
Major adverse cardiovascular events associated with testosterone treatment: a pharmacovigilance study of the FAERS database
Conclusion: For myocardial infarction and cardiomyopathy, TRT statistically tended to increase the risk of MACEs, while for cardiac arrhythmia, cardiac failure, and stroke, TRT demonstrated beneficial effects among the population with morbidities, such as testosterone deficiency (TD), diabetes mellitus (DM), and hypertension. MACEs were rare but led to serious outcomes including significant increase in death and disability. Since 2018, and before 2014, reports referring to TRT associated with MACEs were relatively scarce, which indicated that there might be a considerable number of cases that went unrecorded, due to neglec...
Source: Frontiers in Pharmacology - July 12, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts —A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol
ConclusionThis pilot trial will compare the preliminary effects of nicorandil, diltiazem, and isosorbide mononitrate on angiographic and clinical outcomes in patients who have undergone RA-CABG. Recruitment began in June 2020, and the estimated primary completion date is early 2023. Results of this study will provide much needed information for design of large confirmatory trials on the effectiveness of oral antispastic medications after RA-CABG.
Source: Advances in Therapy - July 11, 2023 Category: Drugs & Pharmacology Source Type: research
The mechanisms of minocycline in alleviating ischemic stroke damage and cerebral ischemia-reperfusion injury
Eur J Pharmacol. 2023 Jul 6:175903. doi: 10.1016/j.ejphar.2023.175903. Online ahead of print.ABSTRACTStroke is a group of diseases resulting from cerebral vascular rupture or obstruction and subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic stroke accounts for the majority of all stroke cases. The current treatments for ischemic stroke mainly include t-PA thrombolytic therapy and surgical thrombectomy. However, these interventions aimed at recanalizing cerebral vessels can paradoxically lead to ischemia-reperfusion injury, which exacerbates the severity of brain damage. Minocycli...
Source: European Journal of Pharmacology - July 8, 2023 Category: Drugs & Pharmacology Authors: Kemeng Zhao Pengwei Wang Xiaoguang Tang Na Chang Haonan Shi Longfei Guo Bingyi Wang Pengfei Yang Tiantian Zhu Xinghua Zhao Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of 3HCatalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification
CONCLUSION: This study initially elucidated the mechanism of HGWD anti-IS, which contributed to the further promotion and secondary development of HGWD in clinical practice.PMID:37410583 | DOI:10.1080/13880209.2023.2230477
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Weiguo Liao Minchun Wang Ying Wu Jinyan Du Yaxin Li Anyu Su Lanying Zhong Zi Xie Mingyu Gong Junhui Liang Pengcheng Wang Zai Liu Lisheng Wang Source Type: research
