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Specialty: Drugs & Pharmacology
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Total 5439 results found since Jan 2013.
Short-term antithrombotic strategies after left atrial appendage occlusion: a systematic review and network meta-analysis
Conclusion: No significant difference was found among patients receiving DAPT, DOACs, and VKA in terms of stroke, DRT, and major bleeding events after LAAO. The SUCRA indicated that DAPT was ranked the worst among all antithrombotic strategies due to the higher risk of stroke, DRT, and major bleeding events, while VKAs were ranked the preferred antithrombotic strategy. However, DOACs are worthy of consideration due to their advantage of convenience.
Source: Frontiers in Pharmacology - September 1, 2023 Category: Drugs & Pharmacology Source Type: research
Retinal stroke: research models, targets and experimental drugs
Expert Opin Investig Drugs. 2023 Aug 31. doi: 10.1080/13543784.2023.2254688. Online ahead of print.ABSTRACTINTRODUCTION: Retinal artery occlusion (RAO), often caused by a microembolus and resulting in inner retinal ischemia, could be considered as the retinal analogue to cerebral stroke. Although several therapeutic targets have been suggested in animal models of retinal ischemia and several potential treatments have been evaluated on small series of patients, central retinal artery occlusion (CRAO) is still rarely treatable in clinical practice.AREAS COVERED: Here, we review several animal models of RAO, including increas...
Source: Expert Opinion on Investigational Drugs - August 31, 2023 Category: Drugs & Pharmacology Authors: Alejandra Daruich Matthieu P Robert Marta Zola Alexandre Matet Dominique Bremond-Gignac Source Type: research
Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women
Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal women has significantly increased. Studies have shown that estrogen deficiency is the main reason for this situation, and supplementing estrogen has become a new direction for preventing the occurrence of postmenopausal fatty liver. However, although classical estrogen replacement therapy can reduce the incidence of postmenopausal N...
Source: Frontiers in Pharmacology - August 30, 2023 Category: Drugs & Pharmacology Source Type: research
Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways
Biomed Pharmacother. 2023 Aug 27;166:115346. doi: 10.1016/j.biopha.2023.115346. Online ahead of print.ABSTRACTHeat stroke (HS) is the deadliest disease. Due to the complex pathogenesis of HS, lack of effective therapeutic drugs for clinical treatment. Shikonin (SK) is the main active compound of Radix Arnebiae, which was evaluated on the HS model (temperature: (41 ± 0.5) ℃, relative humidity: (60 ± 5) %) via pathological and biochemical approaches in vivo and in vitro. Upon the dose of 10 mg.kg-1, SK delays the rising rate of core temperature, prolongs the survival time of mice, and improves organ injury and coagulatio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 29, 2023 Category: Drugs & Pharmacology Authors: Qiong Luo Xin Ye Ji Liang Zhang Xin Huang Xiao Qin Wang Bo Zhang Source Type: research
Clinical Outcomes with GLP-1 Receptor Agonists in Patients with Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials
ConclusionCompared with placebo, GLP-1 RAs may reduce the risk of MACE in patients with HF coexisting with T2DM, with a more significant efficiency of human GLP-1 RAs. More RCTs are needed to assess the cardiovascular benefits of GLP-1 RAs in HF, regardless of T2DM.RegistrationThe protocol for this meta-analysis is registered on PROSPERO [CRD42022357886].Graphical Abstract
Source: Drugs - August 28, 2023 Category: Drugs & Pharmacology Source Type: research
Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis
CONCLUSION: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.PMID:37621078 | PMC:PMC10461497 | DOI:10.1080/13880209.2023.2246501
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Fei Mu Rui Lin Xueyan Lu Meina Zhao Jiaxin Zhao Shaojie Huang Chao Guo Yue Guan Haiyue Zhang Miaomiao Xi Jingwen Wang Haifeng Tang Source Type: research
The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Neuropharmacology. 2023 Aug 22:109690. doi: 10.1016/j.neuropharm.2023.109690. Online ahead of print.ABSTRACTAt present, a large number of relevant studies have suggested that the changes in gut microbiota are related to the course of nervous system diseases, and the microbiota-gut-brain axis is necessary for the proper functioning of the nervous system. Indole and its derivatives, as the products of the gut microbiota metabolism of tryptophan, can be used as ligands to regulate inflammation and autoimmune response in vivo. In recent years, some studies have found that the levels of indole and its derivatives differ signifi...
Source: Neuropharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Yi Zhou Yue Chen Hui He Meichang Peng Meiqin Zeng Haitao Sun Source Type: research
