Filtered By:
Specialty: Drugs & Pharmacology
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 5439 results found since Jan 2013.
Effect of frailty on major bleeding in octogenarian patients undergoing percutaneous coronary intervention
CONCLUSIONS: Frailty is an independent predictor of major bleeding in patients undergoing PCI for acute coronary syndrome. Use of the P2Y12 inhibitor ticagrelor increases the risk of major bleeding in frail patients.PMID:37318490 | DOI:10.26355/eurrev_202306_32633
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: K Özbek A Balun Source Type: research
Dual effect of C-C motif chemokine receptor 5 on ischemic stroke: More harm than benefit?
Eur J Pharmacol. 2023 Jun 13:175857. doi: 10.1016/j.ejphar.2023.175857. Online ahead of print.ABSTRACTIschemic stroke involves a series of complex pathological mechanisms, of which neuroinflammation is currently the most widely recognized. C-C motif chemokine receptor 5 (CCR5) has recently been shown to be upregulated after cerebral ischemia. Notably, CCR5 is not only involved in neuroinflammation, but also in the blood-brain barrier, neural structures, and connections. Accumulating experimental studies indicate that CCR5 has a dual effect on ischemic stroke. In the acute phase after cerebral ischemia, the pro-inflammatory...
Source: European Journal of Pharmacology - June 15, 2023 Category: Drugs & Pharmacology Authors: Kai Jing Feng Chen Xiaofei Shi Jinmin Guo Xia Liu Source Type: research
Effect of frailty on major bleeding in octogenarian patients undergoing percutaneous coronary intervention
CONCLUSIONS: Frailty is an independent predictor of major bleeding in patients undergoing PCI for acute coronary syndrome. Use of the P2Y12 inhibitor ticagrelor increases the risk of major bleeding in frail patients.PMID:37318490 | DOI:10.26355/eurrev_202306_32633
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: K Özbek A Balun Source Type: research
Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke
This study examined the role of sodium butyrate in the prognosis of neurological function in diabetic stroke and the mechanism by which Tregs are amplified in the bilateral cerebral hemispheres. We evaluated the brain infarct volume, observed 48-h neuronal injury and 28-day behavioral changes, and calculated the 28-day survival rate in mice. We also measured Treg levels in peripheral blood and brain tissue, recorded changes in the blood ‒brain barrier and water channel proteins and neurotrophic changes in mice, measured cytokine levels and peripheral B-cell distribution in bilateral hemispheres and peripheral blood, and ...
Source: Journal of NeuroImmune Pharmacology - June 15, 2023 Category: Drugs & Pharmacology Source Type: research
Clinical outcomes of oral anticoagulant discontinuation in atrial fibrillation: a systematic review and meta-analysis
CONCLUSIONS: Discontinuation of OAC therapy was associated with an increased risk of stroke and mortality, with no difference in the risk of major bleeding. Acknowledging heterogeneity among the studies, the findings underline the need to ensure continuity of OAC therapy in patients with AF to prevent thrombotic complications and associated mortality.PROSPERO REGISTRATION NUMBER: CRD42020186116.PMID:37309076 | DOI:10.1080/17512433.2023.2223973
Source: Expert Review of Clinical Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Authors: Adane Teshome Kefale Woldesellassie M Bezabhe Gregory M Peterson Source Type: research
Efficacy and safety of inclisiran in stroke or cerebrovascular disease prevention: a systematic review and meta-analysis of randomized controlled trials
Conclusion: Inclisiran is not beneficial for stroke or MACE prevention in ASCVD or patients at high risk of ASCVD but is associated with the reduction of MI. Given the limited number and quality of the available studies and the lack of a standardized definition for cardiovascular events, further studies are essential for confirming the results.
Source: Frontiers in Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research
Editorial: Targeting inflammation to prevent complications in stroke
Source: Frontiers in Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research
