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Specialty: Drugs & Pharmacology
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Total 5439 results found since Jan 2013.
Clinical Efficacy of the Huo Xue Hua Yu Method Combined with Aspirin in the Treatment of Acute Cerebral Infarction: A systematic evaluation and Meta-Analysis
CONCLUSION: The combination of the Huo Xue Hua Yu method and aspirin represents a beneficial adjunctive therapy for ACI.PMID:37349997 | DOI:10.2174/1381612829666230622110753
Source: Current Pharmaceutical Design - June 23, 2023 Category: Drugs & Pharmacology Authors: Chu Chen Fang Ma Xinli Wen Xing Liu Qing Tang Yilun Wu Source Type: research
Exploring the mechanisms under Zuogui Pill ’s treatment of ischemic stroke through network pharmacology and in vitro experimental verification
Due to its high mortality, incidence and disability rates, ischemic stroke poses heavy economic burdens to families and society. Zuogui Pill (ZGP) is a classic Chinese medicine for tonifying the kidney, which is effective for the recovery of neurological function after ischemic stroke. However, Zuogui Pill has not been evaluated for its potential effects on ischemic strokes. Using network pharmacology, the research aimed to explore the mechanisms of Zuogui Pill on ischemic stroke, which were further validated in SH-SY5Y cells injured by oxygen and glucose deprivation/reperfusion (OGD/R). Network analysis of Zuogui Pill ide...
Source: Frontiers in Pharmacology - June 22, 2023 Category: Drugs & Pharmacology Source Type: research
Effectiveness and Safety of Lacosamide, A Third-generation Anti-seizure Medication, for Poststroke Seizure and Epilepsy: A Literature Review
Curr Neuropharmacol. 2023 Jun 20. doi: 10.2174/1570159X21666230616114255. Online ahead of print.ABSTRACTAdvances in stroke treatment have resulted in a dramatic reduction in stroke mortality. Nevertheless, poststroke seizures and epilepsy are issues of clinical importance affecting survivors. Additionally, stroke is the most common cause of epilepsy in older adults. Although numerous antiseizure medications exist, studies are needed to provide robust evidence of the efficacy and tolerability of these medicines for treating poststroke seizures and epilepsy. Crucially, the newer generations of antiseizure medications require...
Source: Current Neuropharmacology - June 21, 2023 Category: Drugs & Pharmacology Authors: Yu-Shiue Chen Ming-Chi Lai Tsang-Shan Chen Yung-Hsin Tseng Ya Jhen Li Chin-Wei Huang Source Type: research
Loureirin B protects against cerebral ischemia/reperfusion injury through modulating M1/M2 microglial polarization via STAT6 / NF-kappaB signaling pathway
Eur J Pharmacol. 2023 Jun 16;953:175860. doi: 10.1016/j.ejphar.2023.175860. Online ahead of print.ABSTRACTThe latest research indicates that modulating microglial polarization from M1 to M2 phenotype may be a coping therapy for ischemic stroke. The present study thereby evaluated the effects of loureirin B (LB), a monomer compound extracted from Sanguis Draconis flavones (SDF), on cerebral ischemic injury and the potential mechanisms. The middle cerebral artery occlusion (MCAO) model was established in male Sprague-Dawley rats to induce cerebral ischemia/reperfusion (I/R) injury in vivo, and BV2 cells were exposed to oxyge...
Source: European Journal of Pharmacology - June 18, 2023 Category: Drugs & Pharmacology Authors: Rui Li Huiyu Jia Min Si Xinwei Li Zheng Ma Yu Zhu Wuyi Sun Fengqin Zhu Shengyong Luo Source Type: research
Neutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury: Friend and Foe
Curr Neuropharmacol. 2023 Jun 16. doi: 10.2174/1570159X21666230616114255. Online ahead of print.ABSTRACTCerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide, triggers various central nervous system (CNS) diseases, including acute ischemic stroke (AIS) and chronic ischemia-induced Alzheimer's disease (AD). Currently, targeted therapies are urgently needed to address neurological disorders caused by cerebral ischemia/reperfusion injury (CI/RI), and the emergence of neutrophil extracellular traps (NETs) may be able to relieve the pressure. Neutrophils are precursors to brain injury followin...
Source: Current Neuropharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Haoyue Luo Hanjing Guo Yue Zhou Rui Fang Wenli Zhang Zhigang Mei Source Type: research
Dual effect of C-C motif chemokine receptor 5 on ischemic stroke: More harm than benefit?
Eur J Pharmacol. 2023 Jun 13:175857. doi: 10.1016/j.ejphar.2023.175857. Online ahead of print.ABSTRACTIschemic stroke involves a series of complex pathological mechanisms, of which neuroinflammation is currently the most widely recognized. C-C motif chemokine receptor 5 (CCR5) has recently been shown to be upregulated after cerebral ischemia. Notably, CCR5 is not only involved in neuroinflammation, but also in the blood-brain barrier, neural structures, and connections. Accumulating experimental studies indicate that CCR5 has a dual effect on ischemic stroke. In the acute phase after cerebral ischemia, the pro-inflammatory...
Source: European Journal of Pharmacology - June 15, 2023 Category: Drugs & Pharmacology Authors: Kai Jing Feng Chen Xiaofei Shi Jinmin Guo Xia Liu Source Type: research
Effect of frailty on major bleeding in octogenarian patients undergoing percutaneous coronary intervention
CONCLUSIONS: Frailty is an independent predictor of major bleeding in patients undergoing PCI for acute coronary syndrome. Use of the P2Y12 inhibitor ticagrelor increases the risk of major bleeding in frail patients.PMID:37318490 | DOI:10.26355/eurrev_202306_32633
Source: European Review for Medical and Pharmacological Sciences - June 15, 2023 Category: Drugs & Pharmacology Authors: K Özbek A Balun Source Type: research
