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CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES
Condition: Cocaine Use Disorder Interventions: Behavioral: Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter; Biological: 3 blood tests Sponsors: Assistance Publique - Hôpitaux de Paris; Institut National de la Santé Et de la Recherche Médicale, France Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Interdisciplinary collaboration in the diagnosis and management of chronic cough: the role and importance of primary care providers
The objective of this review is to describe the role of PCPs in the diagnosis and treatment of CC in adults. This narrative review draws upon literature (identified via a PubMed search performed January 9, 2023, using primary care/disease state-related terms) and expertise from specialist physicians to provide recommendations for CC management in primary care. Cough is one of the top reasons patients seek care from PCPs; accordingly, PCPs are often the first physicians to conduct workup and initiate treatment. Patients with CC often experience a burdensome cough that lasts for years, have high healthcare resource utilizati...
Source: Current Medical Research and Opinion - September 22, 2023 Category: Research Authors: Peter V Dicpinigaitis Kenneth W Altman Isil Ulger Isci Xuehua Ke Michael Blaiss Source Type: research
Vascular Supply Identification, Lesion Extension and Search for Tumor Similarity at a Distance by VTM in Breast Cancer
Condition: Breast Cancer Female Intervention: Device: VTM examination and breast biopsy Sponsors: Galzu Institute of Research, Teaching, Science and Applied Technology; Hospital Santa Casa de Misericordia de Campos; Hospital Escola Alvaro Alvim; Universidade Estadual do Norte Fluminense (UENF) Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials
Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
Enhancing near-infrared fluorescence intensity and stability of PLGA-b-PEG micelles by introducing Gd-DOTA at the core boundary
In conclusion, we found that overall fluorescence and stability are improved by introducing Gd-DOTA at the boundary of the PLGA core and PEG shell. Improving micelle stability is crucial for further biomedical applications of micellar probes such as bimodal fluorescence and magnetic resonance imaging.PMID:37732480 | DOI:10.1002/jbm.b.35327
Source: Biomed Res - September 21, 2023 Category: Research Authors: Thi Kim Dung Doan Masakazu Umezawa Kyohei Okubo Masao Kamimura Kohei Soga Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis
ConclusionsGCH1 inhibited ferroptosis in LPS-stimulated macrophages, reduced macrophage toward to M1 polarization and inflammatory response.
Source: Inflammation Research - September 21, 2023 Category: Research Source Type: research
The global prevalence of suicidal ideation and suicide attempts among men who have sex with men: a systematic review and meta-analysis
ConclusionConsidering that the prevalence of suicidal ideation and attempts among these people is many times higher than that among men in the general population, developing programs for the prevention of mental disorders with special attention to suicide is necessary for these people. Screening programs are also recommended for early diagnosis and prevention of suicide among these people.
Source: European Journal of Medical Research - September 21, 2023 Category: Research Source Type: research
In Other Words: Sandboxes Aren ’t Just for Kids
Did you know that kids aren’t the only ones playing around in sandboxes? The term sandbox may evoke a childhood memory of sensory play, but it’s also used to describe a virtual environment where someone can learn from digital products.
Credit: NIGMS.
High quantities of data that can be hard to manage, store, and understand are increasingly driving biomedical research. Scientists need access to high-performance computer infrastructure along with bioinformatics tools to do cutting-edge research, but often these resources are out of reach for smaller institutions. Cloud computing can provide access to top-of-the...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques In Other Words Source Type: blogs
Aging Rate Indicators as Speedometers for Aging Research
Is it possible to measure the pace of aging at any given moment? Are there biomarkers that reveal not the biological age of the individual, but rather how fast that biological age is changing? The field is presently focused on developing measures of biological age, such as the extensive work on epigenetic clocks. Some information about pace of aging might be inferred from whether biological age is higher or lower than chronological age, assuming a biological age measurement that is actually accurate, something that still a topic for contention. But that doesn't say anything about the momentary pace of aging at any given ti...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cypate-loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual-modal antibacterial therapy
This study provides ideas for the design of an antibiotic-free antimicrobial strategy against infectious diseases.PMID:37728144 | DOI:10.1002/jbm.a.37613
Source: Biomed Res - September 20, 2023 Category: Research Authors: Zheng Xing Bingyu Dong Xiaoxiao Zhang Lin Qiu Pengju Jiang Yang Xuan Xinye Ni Hongbin Xu Jianhao Wang Source Type: research
