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Total 41502 results found since Jan 2013.

Characterization and biological evaluation of a novel flavonoid-collagen antioxidant hydrogel with cytoprotective properties
J Biomed Mater Res B Appl Biomater. 2023 Sep 16. doi: 10.1002/jbm.b.35321. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three-dimensional architecture. Yet, they lack the inherent antioxidant activity that could help miti...
Source: Biomed Res - September 16, 2023 Category: Research Authors: Danielle M Nalband Prottasha Sarker Saad A Khan Donald O Freytes Source Type: research

A user's guide to degradation testing of polyethylene glycol-based hydrogels: From in vitro to in vivo studies
J Biomed Mater Res A. 2023 Sep 15. doi: 10.1002/jbm.a.37609. Online ahead of print.ABSTRACTPoly(ethylene glycol) (PEG)-based hydrogels have gained significant attention in the field of biomedical applications due to their versatility and antifouling properties. Acrylate-derivatized PEG hydrogels (PEGDA) are some of the most widely studied hydrogels; however, there has been debate around the degradation mechanism and predicting resorption rates. Several factors influence the degradation rate of PEG hydrogels, including backbone and endgroup chemistry, macromer molecular weight, and polymer concentration. In addition to hydr...
Source: Biomed Res - September 16, 2023 Category: Research Authors: Gabriel J Rodriguez-Rivera Mykel Green Vani Shah Kathleen Leyendecker Elizabeth Cosgriff-Hernandez Source Type: research

Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
ConclusionIn this study, we have explored luteolin as one of the active components of YQG, and may inhibit the proliferation and migration of A549 cells by decreasing the expression of AR and the regulation of phosphorylation at AR-binding sites.
Source: European Journal of Medical Research - September 16, 2023 Category: Research Source Type: research

The Open Genes Database of Associations with Aging and Longevity
The Open Genes database provides summaries of the information available on longevity-associated genes, from well-established and well-replicated effects such as that associated with klotho expression, to much less well supported data. Thousands of genes have at least a study or two suggesting an effect on longevity in studies of lower animals, and many of those may turn out to be experimental error. Yet since every fundamental cellular process can be influenced by dozens or hundreds of genes, even though there are comparatively few important processes of aging, one might well expect there be to be thousands of related gene...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

LC-PDA-QTof-MS characterization of the stress degradation products of Zanubrutinib: A novel BTK inhibitor
This study provides comprehensive information on the inherent stability of ZAN which will be useful in the drug development and manufacturing processes.PMID:37713985 | DOI:10.1016/j.jpba.2023.115714
Source: Biomed Res - September 15, 2023 Category: Research Authors: Murali Mohan Bhandi Debasish Swain Srinivas Ragampeta Mohana Krishna Reddy Mudiam Source Type: research

The Antimicrobial Peptide LL-37 as a Predictor Biomarker for Periodontitis with the Presence and Absence of Smoking: A Case-Control Study
CONCLUSION: Periodontitis results in a significant elevation of salivary LL-37 levels in smoker and nonsmoker patients compared to healthy individuals. These levels are positively correlated with the periodontal parameter and can serve as a valuable diagnostic tool to predict periodontitis, whereas smoking significantly reduces these levels.PMID:37711877 | PMC:PMC10499532 | DOI:10.1155/2023/5581267
Source: Biomed Res - September 15, 2023 Category: Research Authors: Wael Abdulazeez Kzar Raghad Fadhil Abbas Hashim Mueen Hussein Source Type: research

Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
CONCLUSION: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition.PMID:37711876 | PMC:PMC10499535 | DOI:10.1155/2023/2594664
Source: Biomed Res - September 15, 2023 Category: Research Authors: Forough Saki Mesbah Shams Sanaz Dastghaib Farhad Koohpeyma Source Type: research

Daily briefing: NASA’s input could be ‘a teachable moment’ for UFO-hunters
Nature, Published online: 15 September 2023; doi:10.1038/d41586-023-02927-5It might be good for science if NASA got involved with the search for aliens on Earth, life-changing cystic fibrosis treatment wins the Breakthrough Prize and a tiny jumping robot that is powered by explosions.
Source: Nature AOP - September 15, 2023 Category: Research Authors: Flora Graham Source Type: research

SPIOMET4HEALTH —efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, fo ur-arm, parallel-group, phase II clinical trial
DiscussionThe present study will be the first to evaluate —in a randomised, double-blind, placebo-controlled way—the efficacy, tolerability and safety of SPIOMET treatment for early PCOS, on top of a lifestyle intervention.Trial registrationEudraCT 2021 –003177-58. Registered on 22 December 2021.https://www.clinicaltrialsregister.eu/ctr-search/search?query=%092021-003177-58.
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials

Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

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