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Total 41502 results found since Jan 2013.
On the track of the lipid transport pathway of the phospholipid flippase ATP8A2 - Mutation analysis of residues of the transmembrane segments M1, M2, M3 and M4
Biochim Biophys Acta Mol Cell Res. 2023 Sep 5:119570. doi: 10.1016/j.bbamcr.2023.119570. Online ahead of print.ABSTRACTP4-ATPases, also known as flippases, translocate specific lipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes, thereby generating an asymmetric lipid distribution essential for numerous cellular functions. A debated issue is which pathway within the protein the lipid substrate follows during the translocation. Here we present a comprehensive mutational screening of all amino acid residues in the transmembrane segments M1, M2, M3, and M4 of the flippase ATP8A2, thus allowin...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Louise S Mogensen Stine A Mikkelsen Francesco Tadini-Buoninsegni Rikke Holm Eli Matsell Bente Vilsen Robert S Molday Jens Peter Andersen Source Type: research
Impact of the lipase inhibitor orlistat on the human gut microbiota
This study aimed to explore the effects of orlistat on the gut microbiota and fatty acid metabolism of Japanese individuals with obesity. Fourteen subjects with visceral fat obesity (waist circumference ≥85 cm) took orlistat orally at a dose of 60 mg, 3 times a day for 8 weeks. Body weight; waist circumference; visceral fat area; levels of short-chain fatty acids, gut microbiota, fatty acid metabolites in the feces, and gastrointestinal hormones; and adverse events were evaluated. Body weight, waist circumference, and blood leptin concentrations were significantly lower after orlistat treatment (mean ± standard deviatio...
Source: Clin Med Res - September 7, 2023 Category: Research Authors: Yudai Uehira Hiroaki Ueno Junki Miyamoto Ikuo Kimura Yohei Ishizawa Hiroshi Iijima Shota Muroga Toru Fujita Soichi Sakai Yoshishige Samukawa Yuri Tanaka Shinya Murayama Hideyuki Sakoda Masamitsu Nakazato Source Type: research
Physicochemical, in vitro and in vivo evaluation of VEGF loaded PCL-mPEG and PDGF loaded PCL-Chitosan dual layered vascular grafts
J Biomed Mater Res B Appl Biomater. 2023 Sep 7. doi: 10.1002/jbm.b.35325. Online ahead of print.ABSTRACTThe present study has attempted to evaluate the endothelialization and smooth muscle regeneration efficiency of a novel dual-layer small-diameter vascular graft. Two types of layers (PCL-mPEG-VEGF and PCL-Chitosan-PDGF) were fabricated to find out the best layer giving endothelialization support for the lumen and unique contractile function for outer layer of blood vessels. Platelet-derived growth factor (PDGF) and chitosan were immobilized onto PCL surface by aminolysis-based surface modification technique. Besides, Pol...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Tamanna Sultana Md Abdullah Al Fahad Myeongki Park Soon Ha Kwon Byong-Taek Lee Source Type: research
Application of the National Comprehensive Cancer Network-distress thermometer in pediatric patients during autologous and allogeneic hematopoietic stem cell transplantation and relationship to blood parameters of the stress axis
CONCLUSIONS: In summary, a significantly increased stress level is shown for both the patients and their parents. This is reflected for the patients both in the DT scores and in the increased cortisol values. For the parents, the focus is primarily on worry and anxiety, for the patients primarily on exhaustion and worry.PMID:37676266 | DOI:10.1007/s00432-023-05300-1
Source: Clin Med Res - September 7, 2023 Category: Research Authors: Carmen Isolde Malaval Karin Melanie Cabanillas Stanchi Dustin Werle Stefanie Thiel Melanie Gansel Peter Lang Rupert Handgretinger Jennifer Svaldi Michaela D öring Source Type: research
Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
J Biomed Mater Res A. 2023 Sep 7. doi: 10.1002/jbm.a.37596. Online ahead of print.ABSTRACTThe goal of this work was to design a polymer-based platform capable of localized, long-term delivery of biologically active neurotropic factors using an affinity-based approach. Here, we synthesized hyaluronic acid-methylfuran (HA-mF) hydrogels that provide sustained, affinity-based release of neurotrophin-3 (NT-3), a growth factor that promotes axon growth for 28 days. A Diels-Alder crosslinking reaction between HA-mF and polyethylene glycol (PEG)-dimaleimide occurs within 15 min under physiological conditions, resulting in hydrogel...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Pablo Ramos Ferrer Sangamithra Vardhan Shelly Sakiyama-Elbert Source Type: research
COVID-19: An Overview of SARS-CoV-2 Variants-The Current Vaccines and Drug Development
Biomed Res Int. 2023 Aug 29;2023:1879554. doi: 10.1155/2023/1879554. eCollection 2023.ABSTRACTThe world is presently in crisis facing an outbreak of a health-threatening microorganism known as COVID-19, responsible for causing uncommon viral pneumonia in humans. The virus was first reported in Wuhan, China, in early December 2019, and it quickly became a global concern due to the pandemic. Challenges in this regard have been compounded by the emergence of several variants such as B.1.1.7, B.1.351, P1, and B.1.617, which show an increase in transmission power and resistance to therapies and vaccines. Ongoing researches are ...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Narjess Bostanghadiri Pardis Ziaeefar Morvarid Golrokh Mofrad Parsa Yousefzadeh Ali Hashemi Davood Darban-Sarokhalil Source Type: research
Spatio-temporal distribution & amp; seasonality of highly pathogenic avian influenza H5N1 & amp; H5N8 outbreaks in India, 2006-2021
CONCLUSIONS: Such studies on the seasonality of HPAI outbreaks would help in the development of prevention and control strategies. The recent human infections of H5N1 and H9N2 viruses highlight the need to strengthen surveillance in wild, resident, migratory birds and in poultry along with One Health studies in India.PMID:37675691 | DOI:10.4103/ijmr.ijmr_2002_22
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Shailesh D Pawar Sadhana S Kode Sachin S Keng Deeksha S Tare Satish A Pande Source Type: research
Authors' response
Indian J Med Res. 2023 Sep 6. doi: 10.4103/0971-5916.384245. Online ahead of print.NO ABSTRACTPMID:37675690 | DOI:10.4103/0971-5916.384245
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Jatin Sharma C S Gautam Harmanjit Singh Jagjit Singh Source Type: research
Determinants of post discharge mortality among hospitalized COVID-19 patients: Nested matched case-control analyses from the National Clinical Registry for COVID-19
CONCLUSIONS: : Prior vaccination protects against post discharge mortality till one year in hospitalized COVID-19 patients. PCC may have long term deleterious effects, including mortality, for which further research is warranted.PMID:37675689 | DOI:10.4103/ijmr.ijmr_973_23
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Gunjan Kumar Arunansu Talukdar Alka Turuk Ashish Bhalla Subhasis Mukherjee Pankaj Bhardwaj Tarun Bhatnagar Aparna Mukherjee Source Type: research
Tafenoquine for the radical cure < em > versus < /em > prophylaxis of < em > Plasmodium vivax < /em > malaria: the importance of using the appropriate data set
Indian J Med Res. 2023 Sep 6. doi: 10.4103/ijmr.ijmr_405_23. Online ahead of print.NO ABSTRACTPMID:37675688 | DOI:10.4103/ijmr.ijmr_405_23
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Raman Sharma Chao Chen Ioana-Gabriela Fi ţa Rachel A Gibson Si ôn Jones Anup Pingle Katie Rolfe Hema Sharma Panayota Bird Source Type: research
Eco-epidemiology triad to explain infectious diseases
Indian J Med Res. 2023 Sep 6. doi: 10.4103/ijmr.ijmr_3031_21. Online ahead of print.NO ABSTRACTPMID:37675687 | DOI:10.4103/ijmr.ijmr_3031_21
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: T Jacob John Rajeev Zachariah Kompithra Source Type: research
Biofilm profile of candidaemia isolates
Indian J Med Res. 2023 Sep 6. doi: 10.4103/ijmr.ijmr_2214_21. Online ahead of print.NO ABSTRACTPMID:37675686 | DOI:10.4103/ijmr.ijmr_2214_21
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: M S Sheena Rakesh Singh Source Type: research
Evidence-based traditional medicine for transforming global health & amp; wellbeing
Indian J Med Res. 2023 Sep 6. doi: 10.4103/ijmr.ijmr_1574_23. Online ahead of print.NO ABSTRACTPMID:37675685 | DOI:10.4103/ijmr.ijmr_1574_23
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Bhushan Patwardhan L Susan Wieland Obijiofor Aginam Anchalee Chuthaputti Ricardo Ghelman Roshanak Ghods Goh Cheng Soon Motlalepula G Matsabisa Georg Seifert Sione Tu'itahi Kim Sung Chol Shyama Kuruvilla Kathi Kemper Holger Cramer H R Nagendra Anup Thakar Source Type: research
Correlation of < em > CYP2R1 < /em > gene promoter methylation with circulating vitamin D levels among healthy adults
CONCLUSIONS: This study found no significant correlation between levels of CYP2R1 methylation and circulating 25(OH)D deficiency. Further studies on the Indian population having a larger sample size including entire vitamin D tool genes, among different ethnic groups may be conducted to elucidate molecular etiology of circulating 25(OH)D deficiency. The high prevalence of normal serum calcium and phosphate levels among vitamin D deficient subjects in this study coupled with the strikingly high prevalence of the deficiency at the national level, may suggest the need to revise the cut-off criteria for vitamin D deficiency in...
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Ashvin Varadharajan M K Sibin S V Athira Arijit Kumar Ghosh Pratibha Misra Source Type: research
Spatio-temporal distribution & amp; seasonality of highly pathogenic avian influenza H5N1 & amp; H5N8 outbreaks in India, 2006-2021
CONCLUSIONS: Such studies on the seasonality of HPAI outbreaks would help in the development of prevention and control strategies. The recent human infections of H5N1 and H9N2 viruses highlight the need to strengthen surveillance in wild, resident, migratory birds and in poultry along with One Health studies in India.PMID:37675691 | DOI:10.4103/ijmr.ijmr_2002_22
Source: Indian J Med Res - September 7, 2023 Category: Research Authors: Shailesh D Pawar Sadhana S Kode Sachin S Keng Deeksha S Tare Satish A Pande Source Type: research
