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Management: Mergers and Aquisitions
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Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology
Ultrastructural analysis of discrete neurobiological structures by volume scanning electron microscopy (SEM) often constitutes a “needle-in-the-haystack” problem and therefore relies on sophisticated search strategies. The appropriate SEM approach for a given relocation task not only depends on the desired final image quality but also on the complexity and required accuracy of the screening process. Block-face SEM techniques like Focused Ion Beam or serial block-face SEM are “one-shot” imaging runs by nature and, thus, require precise relocation prior to acquisition. In contrast, “multi-shot” approaches conserv...
Source: Frontiers in Neuroanatomy - October 13, 2021 Category: Neurology Source Type: research
Immobilisation and flow chemistry: Tools for implementing biocatalysis
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Jose Coloma, Yann Guiavarc ’h, Peter Leon Hagedoorn, Ulf Hanefeld The merger of enzyme immobilisation and flow chemistry has attracted the attention of the scientific community during the last years. Immobilisation enhances enzyme stability and enables recycling, flow chemistry allows... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - October 5, 2021 Category: Chemistry Authors: Jose Coloma Source Type: research
The FTC ’s Absurd Attempts At Defining Facebook’s Product Market
Ryan BourneWhen it comes to Facebook, antitrust authorities are making it up as they go along. The company is extremely big, and so necessarily “bad” in the eyes of today’sneo-Brandeisian trustbusting movement, one member of whom, Lina Khan, now chairs the Federal Trade Commission. These people just know that Facebook is a monopolist using its market power anticompetitively, and so see the task of their agencies to define the market to first prove that Facebook meets the conditions necessary for antitrust action against them.Back in late June, the U.S. District Court in DC threw out a complaint by the FTC against Fac...
Source: Cato-at-liberty - August 20, 2021 Category: American Health Authors: Ryan Bourne Source Type: blogs
ChimST: An Efficient Spectral Library Search Tool for Peptide Identification from Chimeric Spectra in Data-Dependent Acquisition
Source: IEEE/ACM Transactions on Computational Biology and Bioinformatics - August 6, 2021 Category: Bioinformatics Source Type: research
Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination
The appearance of adaptive immunity in jawed vertebrates is termed the immunological ‘Big Bang’ because of the short evolutionary time over which it developed. Underlying it is the recombination activating gene (RAG)-based V(D)J recombination system, which initiates the sequence diversification of the immunoglobulins and lymphocyte antigen receptors. It was convincingly argued that the RAG1 and RAG2 genes originated from a single transposon. The current dogma postulates that the V(D)J recombination system was established by the split of a primordial vertebrate immune receptor gene into V and J segments by a RAG1/2 tran...
Source: Frontiers in Immunology - July 28, 2021 Category: Allergy & Immunology Source Type: research
Google ’ s Masterplan for Healthcare
With 7% of Google searches – or 70,000 per minute – being health-related, it was only a matter of time before the search giant aimed to be a healthcare giant. Google hasn’t been particularly shy at expressing these ambitions either. It purchased Fitbit for $2.1 billion and had a dedicated healthcare offshoot from its A.I. branch, Deepmind.
In this new article series exploring the latest moves by tech giants into healthcare, we will look at recent developments coming from Google. Previous entries looked at the moves of Google’s competitors Amazon and Apple, and provided insights into the trends that those companies ...
Source: The Medical Futurist - July 27, 2021 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Digital Health Research Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy AI genetics google Healthcare Innovation technolog Source Type: blogs
Cardiac arrest
I was watching the Euro 2020 game between Denmark and Finland, I am sure encouraged by the presence of a Norwich City player on one side and a Leicester City one on the other. I did not see Christian Eriksen fall but I watched as his teammates formed a barrier round him, and perhaps saw too much as the television companies made a decision what to do.I was, along with everyone, so pleased that the prompt treatment given to Christian Eriksen brought him back and that he is now recovering.It was a cardiac arrest - not the same thing as a heart attack - and theBritish Heart Foundation have a useful page about what ...
Source: Browsing - June 17, 2021 Category: Databases & Libraries Tags: cardiac arrest defibrillators Source Type: blogs
Salience effects in information acquisition: No evidence for a top-down coherence influence
Mem Cognit. 2021 Jun 16. doi: 10.3758/s13421-021-01188-9. Online ahead of print.ABSTRACTThe Integrated Coherence-Based Decision and Search (iCodes) model proposed by Jekel et al. (Psychological Review, 125 (5), 744-768, 2018) formalizes both decision making and pre-decisional information search as coherence-maximization processes in an interactive network. Next to bottom-up attribute influences, the coherence of option information exerts a top-down influence on the search processes in this model, predicting the tendency to continue information search with the currently most attractive option. This hallmark "attraction sear...
Source: Memory and Cognition - June 16, 2021 Category: Neuroscience Authors: Arndt Br öder Sophie Scharf Marc Jekel Andreas Gl öckner Nicole Franke Source Type: research
GSE173837 RNA-seq and small RNA-seq in fission yeast CPF mutants that enable small-RNA-mediated epigenetic gene silencing
In this study, we have combined chemical mutagenesis with whole-genome sequencing in a sensitized S. pombe reporter strain to obtain a more comprehensive list of putative suppressors of small-RNA-mediated epigenetic gene silencing. This revealed more than 20 novel silencing-enabling mutations in genes that are associated with RNA processing, regulation of transcription, or post-translational protein modification. Focusing on factors involved in pre-mRNA cleavage and polyadenylation, we for example show that single amino acid substitutions in Yth1, which is responsible for polyadenylation signal recognition, lead to nearly ...
Source: GEO: Gene Expression Omnibus - June 7, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Schizosaccharomyces pombe Source Type: research
Determining Usefulness of Machine Learning in Materials Discovery Using Simulated Research Landscapes
Phys. Chem. Chem. Phys., 2021, Accepted Manuscript DOI: 10.1039/D1CP01761F, PaperMarcos del Cueto, Alessandro Troisi When existing experimental data are combined with machine learning (ML) to predict the performance of new materials, the data acquisition bias determines ML usefulness and the prediction accuracy. In this... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - May 29, 2021 Category: Chemistry Authors: Marcos del Cueto Source Type: research
60Fe and 244Pu deposited on Earth constrain the r-process yields of recent nearby supernovae
Half of the chemical elements heavier than iron are produced by the rapid neutron capture process (r-process). The sites and yields of this process are disputed, with candidates including some types of supernovae (SNe) and mergers of neutron stars. We search for two isotopic signatures in a sample of Pacific Ocean crust—iron-60 (60Fe) (half-life, 2.6 million years), which is predominantly produced in massive stars and ejected in supernova explosions, and plutonium-244 (244Pu) (half-life, 80.6 million years), which is produced solely in r-process events. We detect two distinct influxes of 60Fe to Earth in the last 10 ...
Source: Science: Current Issue - May 13, 2021 Category: Science Authors: Wallner, A., Froehlich, M. B., Hotchkis, M. A. C., Kinoshita, N., Paul, M., Martschini, M., Pavetich, S., Tims, S. G., Kivel, N., Schumann, D., Honda, M., Matsuzaki, H., Yamagata, T. Tags: Astronomy, Geochemistry, Geophysics, Physics reports Source Type: research
Non-uniform sampling in pulse dipolar spectroscopy by EPR: the redistribution of noise and the optimization of data acquisition
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Anna G. Matveeva, Victoria N. Syryamina, Vyacheslav M. Nekrasov, Michael K. Bowman Non-uniform schemes for collection of pulse dipole spectroscopy data can decrease and redistribute noise in the distance spectrum for increased sensitivity and throughput. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 21, 2021 Category: Chemistry Authors: Anna G. Matveeva Source Type: research
The risk of mortality in patients with COVID-19 with pre-diagnosis use of NSAIDs: a meta-analysis
AbstractThe notion that the use of non-steroidal anti-inflammatory drugs (NSAIDs) may lead to adverse outcomes upon acquisition of coronavirus disease 2019 (COVID-19) should be discredited with a review of the real-life evidence. We aimed to perform a meta-analysis to summarize the risk of mortality with the preadmission/pre-diagnosis use of NSAIDs in patients with COVID-19. A systematic literature search was performed to identify eligible studies in electronic databases. The outcome of interest was the development of a fatal course of COVID-19. Adjusted hazard ratio or odds ratio/relative risk and the corresponding 95% co...
Source: Inflammopharmacology - April 21, 2021 Category: Drugs & Pharmacology Source Type: research
Dentulu Closes $2.5 Million Seed Fund Round for Aggressive Development of Its Global Teledentistry Platform
Acquires Robohealer AI, Adding Artificial Intelligence Capabilities to Its Software Platform and Announces Expansion of the Dentulu Strategic Partner Network Los Angeles, CA; April 12, 2021– Dentulu announces the closing of an initial seed round investment of $2.5M as well as the acquisition of Robohealer AI. Robohealer, is a dynamic interactive symptom screener which uses artificial intelligence to make teleconsultations and care recommendations easy for patients and efficient for dentists.“Dentulu’s mission is to increase direct access to dental care for billions of people worldwide,” said Dentul...
Source: Dental Technology Blog - April 13, 2021 Category: Dentistry Source Type: news
Single-Scan Measurements of Nuclear Spin Singlet Order Decay Rates
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Giulia Melchiorre, Ciara Nelder, Lynda Jane Brown, Jean-Nicolas Dumez, Giuseppe Pileio Measurement of singlet spin order decay rates are time consuming due to the long-lived nature of this form of order and the typical pseudo-2D mode of acquisition. Additionally, this acquisition... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - March 27, 2021 Category: Chemistry Authors: Giulia Melchiorre Source Type: research
