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Total 416 results found since Jan 2013.

Targeting Bcl-2 Family Proteins: What, Where, When?
AbstractProteins of the Bcl-2 family are known as regulators of apoptosis, one of the most studied forms of programmed cell death. The Bcl-2 protein family is represented by both pro- and antiapoptotic members. Antiapoptotic proteins are often exploited by tumor cells to avoid their death, thus playing an important role in carcinogenesis and in acquisition of resistance to various therapeutic agents. Therefore, antiapoptotic proteins represent attractive targets for cancer therapy. A detailed investigation of interactions between Bcl-2 family proteins resulted in the development of highly selective inhibitors of individual...
Source: Biochemistry (Moscow) - October 1, 2020 Category: Biochemistry Source Type: research

Low-power STMAS – breaking through the limit of large quadrupolar interactions in high-resolution solid-state NMR spectroscopy
Phys. Chem. Chem. Phys., 2020, Advance Article DOI: 10.1039/D0CP04274A, PaperIvan Hung, Zhehong Gan The STMAS NMR experiment reported requires significantly lower rf fields and allows acquisition of high-resolution spectra for large quadrupolar interactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 21, 2020 Category: Chemistry Authors: Ivan Hung Source Type: research

Federal Aid Creates Central ‐​Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state received in 2020 fro...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs

Surface Enhanced Raman Scattering for Robust, Sensitive Detection and Confirmatory Identification of Dried Bloodstains
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN01132K, PaperMiranda Shaine, Ranjith Premasiri, Harrison M. Ingraham, Richard S Andino, Paul Lemler, Amy Brodeur, Lawrence D Ziegler An optimized procedure is described for the acquisition of 785 nm excited SERS spectra of dried bloodstains and shown to offer great potential for rapid, portable, highly sensitive and specific,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - August 19, 2020 Category: Chemistry Authors: Miranda Shaine Source Type: research

Lifelong learning through skillful self-reflection
The dictionary definition of learning is“the acquisition of knowledge or skills through experience, study, or by being taught.” For leaders, the most crucial and common way of learning happens through experience, and as we often say, leadership is flying the plane while building it. Moreover, the onus of making the process of learning an […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - August 12, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/priti-golechha" rel="tag" > Priti Golechha, MD < /a > < /span > Tags: Physician Practice Management Source Type: blogs

Molecules, Vol. 25, Pages 3492: Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes
ski Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycl...
Source: Molecules - July 30, 2020 Category: Chemistry Authors: Katarzyna Ga łczyńska Zuzanna Drulis-Kawa Micha ł Arabski Tags: Review Source Type: research

Gain and Loss of Flight as a Tool to Search for Import Factors in Longevity
The capacity for flight is frequently associated with greater species longevity, such as in bats, for example. The present consensus suggests that the cellular adaptations needed to support the greater metabolic capacity required for flight also resist some forms of molecular damage important in aging. This is particularly the case for adaptations in mitochondria, the power plants of cells, where damage and loss of function is known to be important in aging. The membrane pacemaker hypothesis is one way of looking at this; species that evolve cell membranes that are more resilient to oxidative damage will live longer as a r...
Source: Fight Aging! - July 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Parallel micro-Raman spectroscopy of multiple cells in a single acquisition using hierarchical sparsity
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN01081B, PaperPengfei Zhang, Guiwen Wang, Shushi Huang Parallel micro-Raman spectroscopy can significantly expand the analytical capacity of single biological cells. By positioning the Raman spectra of multiple trapped cells on a detector array along the grating dispersion... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - July 9, 2020 Category: Chemistry Authors: Pengfei Zhang Source Type: research

Convenient and sensitive colorimetric determination of alendronate sodium with Ce4+-triggered oxidation of TMB
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02816A, PaperJing Sun, Rui Wang, Meng Xia, Shuyun Zhu, Xian-en Zhao As alternatives of nanozymes, some metal ions have been used in chemical/biochemical sensors owing to their facile acquisition avoiding tedious preparation and purification. Ce4+ has been reported to possess oxidase-like... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - July 6, 2020 Category: Chemistry Authors: Jing Sun Source Type: research

Doximity Acquires THMED, Launches Curative Brand
Doximity, the professional medical network, has acquired THMED, a leading healthcare staffing solutions company. THMED has changed its name to Curative to reflect the new company empowered by Doximity’s technology and network. Together, the two companies have created a first-ever business model for healthcare staffing that uses technology to re-engineer delivery by focusing on personalized search that […]
Source: EMR and HIPAA - June 18, 2020 Category: Information Technology Authors: Healthcare IT News Tags: Career and Jobs Clinical Health IT Company Healthcare IT Curative Doximity Health IT Acquisition Healthcare Staffing Jeff Bowling Jeff Tangey THMED Source Type: blogs

Tech Giants in Healthcare: New E-Book with a COVID-19 Special Edition
Considering that the healthcare industry is expected to exceed  $11 trillion by 2022, it might not come as a surprise that big tech companies like Google, Apple, Facebook or even Uber want a share of this cake. Even if their business is flourishing elsewhere, these companies stand more to gain than green bills. More importantly, investing in healthcare is an adequate way to build user trust. Our latest e-book analyzing those endeavours and more is available here. Tech Giants in Healthcare This comprehensive guide, Tech Giants in Healthcare, clarifies how and wh...
Source: The Medical Futurist - May 28, 2020 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Security & Privacy AI amazon apple artificial intelligence genetics genomics google Health Healthcare IBM ibm watson research smartphone technology microsoft market Source Type: blogs

Roche acquires Stratos Genomics to further develop DNA based sequencing for diagnostic use
Basel, 22 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that it has acquired Stratos Genomics, an early-stage sequencing technology company to advance the development of Roche ’s nanopore sequencer. The acquisition provides Roche access to Stratos Genomics unique chemistry, Sequencing by Expansion (SBX™). The Roche nanopore sequencer, once developed, will utilise a novel approach that combines electronic and biological components to sequence DNA for fast, flexible and cost-effective clinical diagnostic testing.“Roche is dedicated to creating innovative diagnostics for the most challenging clinical con...
Source: Roche Media News - May 22, 2020 Category: Pharmaceuticals Source Type: news

Employment Status and Well-Being: A Longitudinal Study on Young Italian People
AbstractJob insecurity and precariousness lead Young Italian people to stop in their paths of life and life plan. The effect is to lead them in a spiral of marginality and demotivation typical of NEETs (young people who do not work, do not study and are not in a period training), with a serious impairment of the quality of life. The aim of this work is to show the impact of the occupational condition on the well-being of young people, both from a static and dynamic point of view, by using the database of the “Rapporto Giovani” longitudinal survey, a representative sample of Young Italian people. The entrance and the ex...
Source: Social Indicators Research - May 16, 2020 Category: International Medicine & Public Health Source Type: research

A formative figure in the company ' s history: Roche Honorary Chairman Fritz Gerber dies at the age of 91
Basel, 11 Mai 2020- On May 10th 2020 Dr. h.c. Fritz Gerber died in his 92nd year. For more than two decades, he had shaped Roche ' s development into a leading global healthcare company in an exceptionally successful dual role as Group CEO (1978-1998) and Chairman of the Board (1978-2001). He remained closely associated with Roche throughout his life as Honorary Chairman. Starting at the end of the 1970s, Fritz Gerber led the company from a difficult situation to new success. Under his leadership, Roche ' s Group structures were fundamentally renewed and decentralized – ranging from focusing on the core businesses to mod...
Source: Roche Investor Update - May 11, 2020 Category: Pharmaceuticals Source Type: news