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Infectious Disease: Adenoviruses
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Total 6070 results found since Jan 2013.
A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients
Front Pediatr. 2023 Sep 4;11:1252495. doi: 10.3389/fped.2023.1252495. eCollection 2023.ABSTRACTPediatric solid organ transplant is a life-saving procedure for children with end-stage organ failure. Viral infections are a common complication following pediatric solid organ transplantation (SOT), which can lead to increased morbidity and mortality. Pediatric solid organ transplant recipients are at an increased risk of viral infections due to their immunosuppressed state. The most commonly encountered viruses include cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella-zoster virus (VZV), ad...
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Marjan Moghadamnia Hamid Eshaghi Hosein Alimadadi Simin Dashti-Khavidaki Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
Euro Surveill. 2023 Sep;28(38). doi: 10.2807/1560-7917.ES.2023.28.38.2300171.ABSTRACTOn 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts an...
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Berta Grau-Pujol Jo ão Vieira Martins Isabel Goncalves Fernanda Rodrigues Rita de Sousa Dina Oliveira Joana Bettencourt Diana Mendes In ês Mateus de Cunha Sara Pocinho Ana Firme Benvinda Estela Dos Santos Andr é Peralta Santos Maria Jo ão Albuquerque Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells
CONCLUSION: ACE2 overexpression can inhibit HSC activation and promote cell apoptosis by regulating HSC autophagy through the AMPK/mTOR pathway, thereby alleviating liver fibrosis and hepatic sinusoidal remodeling.PMID:37732000 | PMC:PMC10507507 | DOI:10.3748/wjg.v29.i33.4975
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Ying Wu Ai-Hong Yin Jun-Tao Sun Wei-Hua Xu Chun-Qing Zhang Source Type: research
Enteroviral central nervous system infections in patients with Lyme neuroborreliosis
Ticks Tick Borne Dis. 2023 Sep 18;14(6):102253. doi: 10.1016/j.ttbdis.2023.102253. Online ahead of print.ABSTRACTPatients with Lyme neuroborreliosis (LNB) are rarely tested for the presence of neurovirulent viruses other than tick-borne encephalitis virus (TBEV); however, such coinfections could be of clinical importance. The aim of the study was to search for the presence of neurotropic viruses in a LNB patients. Fourteen patients admitted with signs and symptoms of neuroinfection who were eventually diagnosed to have LNB (according to the guidelines of the European Federation of Neurological Societies) were subjects of t...
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Karol Perlejewski Marek Radkowski Agnieszka Pawe łczyk Ma łgorzata Rydzanicz Tomasz Dzieci ątkowski Micha ł Makowiecki Marcin Paciorek Renata Welc-Fal ęciak Andrzej Horban Tomasz Laskus Source Type: research
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
This article is protected by copyright. All rights reserved.PMID:37728197 | DOI:10.1002/biot.202300230
Source: Biotechnology Journal - September 20, 2023 Category: Biotechnology Authors: Shriarjun Shastry Wenning Chu Eduardo Barbieri Paul Greback-Clarke William K Smith Christopher Cummings Arianna Minzoni Jennifer Pancorbo Gary Gilleskie Kimberly Ritola Michael A Daniele Thomas F Johnson Stefano Menegatti Source Type: research
Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling
Int Immunopharmacol. 2023 Sep 18;124(Pt B):110896. doi: 10.1016/j.intimp.2023.110896. Online ahead of print.ABSTRACTElevated evidence has reported the important role of oxidative stress injury and inflammatory response in the progression of colitis. Tumor Suppressor TSBF1, TRIM59, is a ubiquitin E3 ligase and mediates immune response. However, the underlying molecular function of TRIM59 on regulation of colitis is still not understood. In the current study, we identify the TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1), and we also determine that TRIM59 is a KEAP1-intera...
Source: International Immunopharmacology - September 20, 2023 Category: Allergy & Immunology Authors: Bing Liu Yongsheng Gao Xin Liu Qin Lian Yanliang Li Source Type: research
Engineered human adenoviruses of species B and C report early, intermediate early and late viral gene expression
Hum Gene Ther. 2023 Sep 19. doi: 10.1089/hum.2023.121. Online ahead of print.ABSTRACTAdenoviruses (AdVs) are being developed for oncolytic or vaccination therapy against existing and emerging conditions. Well-characterized replication-competent human and human primate AdVs expressing multiple payloads are desirable, but their replication in rodent models is limited. To score the timing of adenoviral gene expression in cell cultures, we developed fully replication-competent transcriptional reporter viruses for HAdV-C5, -B3 and -B35. The picornavirus-derived 2A sequence, which induces cotranslational peptide splitting and re...
Source: Adv Data - September 19, 2023 Category: Epidemiology Authors: Tania Jetzer Lukas Studer Manuela Bieri Urs Greber Silvio Hemmi Source Type: research
LKB1 delays atherosclerosis by inhibiting phenotypic transformation of vascular smooth muscle cells
CONCLUSION: Our results suggested that LKB1 can delay the progression of atherosclerosis by inhibiting the phenotypic transition of VSMCs.PMID:37722454 | DOI:10.1016/j.ijcard.2023.131363
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Kaicong Chen Chunyan Zhu Qing Zhang Zhihuan Zeng Rong Chen Tudi Li Junqian Luo Zihao Zhou Rui Zeng Source Type: research
PR-957 retards rheumatoid arthritis progression and inflammation by inhibiting LMP7-mediated CD4 < sup > + < /sup > T cell imbalance
CONCLUSION: PR-957 ameliorates RA progression and inflammation by repressing LMP7-mediated CD4+ T cell imbalance.PMID:37716163 | DOI:10.1016/j.intimp.2023.110860
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Qingyang Liu Jin Shen Jian Wang Jinjun Xia Jian Yin Guowei Cheng Ximing Qian Yun Jiang Xin Ge Qiubo Wang Source Type: research
