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Infectious Disease: Adenoviruses
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Total 6070 results found since Jan 2013.
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Int Rev Cell Mol Biol. 2023;379:241-261. doi: 10.1016/bs.ircmb.2023.03.004. Epub 2023 Apr 1.ABSTRACTOncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here, we propose a set of selection criteria or ideal properties of a successful oncolytic virus, which include lack of pathogenic...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Rupsa Basu Chad M Moles Source Type: research
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26.ABSTRACTHigh-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these tumors due to its oncolytic and immunostimulatory properties. Various oncolytic viruses, such as herpes simplex virus, adenov...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Irati Herv ás-Corpión Marta M Alonso Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
NLRP12 attenuates ozone-induced pulmonary inflammation by regulating canonical NF- κB Pathway
Ecotoxicol Environ Saf. 2023 Jul 31;262:115275. doi: 10.1016/j.ecoenv.2023.115275. Online ahead of print.ABSTRACTOzone (O3) is an important urban air pollutant having strong correlations with respiratory diseases. Several lines of evidence suggest that O3 exposure causes airway hyperresponsiveness (AHR) and pulmonary inflammation. Inhibitory innate immune receptors, such as NLRP12, have been demonstrated to alleviate inflammation, but the functional role for NLRP12 in O3-induced lung inflammatory inflammation remains to be reported. Here, we determined whether NLRP12 took a protective role in O3-induced AHR and pulmonary i...
Source: Ecotoxicology and Environmental Safety - August 2, 2023 Category: Environmental Health Authors: Mengyuan Li Yuan Xue Xinyi Miao Pengwei Ma Xiangbing Kong Yuefei Jin Yan Li Wei Wang Qiao Zhang Qihong Deng Feifei Feng Source Type: research
Random Integration Analysis of Recombinant Adeno-Associated Virus 6 Packaged in Sf9 Insect Cells
In this study, we used different doses of Baculo-Sf9 produced rAAV6-EGFP to transduce HEK293T cells and A549-implanted tumors in vitro and in vivo. Using flow cytometry and fluorescence microscopy, we studied their EGFP gene expression efficiencies and EGFP fluorescence intensities. Using inverse nested PCR and DNA sequencing, random integration sites of rAAV6-EGFP genome into human chromosomes were identified. In vitro results showed that gene expression efficiencies became stable after 20 days and random integration frequencies were 0.2-4.2%. Both in vitro and in vivo results indicated that random integration of Baculo-S...
Source: Molekuliarnaia Biologiia - August 2, 2023 Category: Molecular Biology Authors: M H Zhang X M Liu C Zhang Source Type: research
Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019
Virol J. 2023 Aug 2;20(1):170. doi: 10.1186/s12985-023-02079-y.ABSTRACTViral infections of the central nervous system (CNS) are common worldwide and result in considerable morbidity and mortality associated with neurologic illness. Until now, there have been no epidemiologic data regarding viruses causing aseptic meningitis, encephalitis, and CNS infections in Egypt. We investigated 1735 archived cerebrospinal fluid samples collected from Egyptian patients between 2016 and 2019 and performed molecular characterization for infection for12 different viruses: herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster ...
Source: Adv Data - August 2, 2023 Category: Epidemiology Authors: Wael H Roshdy Ahmed Kandeil Manal Fahim Nourhan Y Naguib Gehad Mohsen Shaymaa Shawky Marwa M Abd El-Fattah Amel Naguib Azza Salamony Yara I Shamikh Mahmoud Moawad Nancy El Guindy Mohamed K Khalifa Eman Abbas Ramy Galal Mohamed Hassany Mohamed Ibrahem Rabe Source Type: research
Random Integration Analysis of Recombinant Adeno-Associated Virus 6 Packaged in Sf9 Insect Cells
In this study, we used different doses of Baculo-Sf9 produced rAAV6-EGFP to transduce HEK293T cells and A549-implanted tumors in vitro and in vivo. Using flow cytometry and fluorescence microscopy, we studied their EGFP gene expression efficiencies and EGFP fluorescence intensities. Using inverse nested PCR and DNA sequencing, random integration sites of rAAV6-EGFP genome into human chromosomes were identified. In vitro results showed that gene expression efficiencies became stable after 20 days and random integration frequencies were 0.2-4.2%. Both in vitro and in vivo results indicated that random integration of Baculo-S...
Source: Molekuliarnaia Biologiia - August 2, 2023 Category: Molecular Biology Authors: M H Zhang X M Liu C Zhang Source Type: research
Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019
Virol J. 2023 Aug 2;20(1):170. doi: 10.1186/s12985-023-02079-y.ABSTRACTViral infections of the central nervous system (CNS) are common worldwide and result in considerable morbidity and mortality associated with neurologic illness. Until now, there have been no epidemiologic data regarding viruses causing aseptic meningitis, encephalitis, and CNS infections in Egypt. We investigated 1735 archived cerebrospinal fluid samples collected from Egyptian patients between 2016 and 2019 and performed molecular characterization for infection for12 different viruses: herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster ...
Source: Herpes - August 2, 2023 Category: Infectious Diseases Authors: Wael H Roshdy Ahmed Kandeil Manal Fahim Nourhan Y Naguib Gehad Mohsen Shaymaa Shawky Marwa M Abd El-Fattah Amel Naguib Azza Salamony Yara I Shamikh Mahmoud Moawad Nancy El Guindy Mohamed K Khalifa Eman Abbas Ramy Galal Mohamed Hassany Mohamed Ibrahem Rabe Source Type: research
Random Integration Analysis of Recombinant Adeno-Associated Virus 6 Packaged in Sf9 Insect Cells
In this study, we used different doses of Baculo-Sf9 produced rAAV6-EGFP to transduce HEK293T cells and A549-implanted tumors in vitro and in vivo. Using flow cytometry and fluorescence microscopy, we studied their EGFP gene expression efficiencies and EGFP fluorescence intensities. Using inverse nested PCR and DNA sequencing, random integration sites of rAAV6-EGFP genome into human chromosomes were identified. In vitro results showed that gene expression efficiencies became stable after 20 days and random integration frequencies were 0.2-4.2%. Both in vitro and in vivo results indicated that random integration of Baculo-S...
Source: Molekuliarnaia Biologiia - August 2, 2023 Category: Molecular Biology Authors: M H Zhang X M Liu C Zhang Source Type: research
NLRP12 attenuates ozone-induced pulmonary inflammation by regulating canonical NF- κB Pathway
Ecotoxicol Environ Saf. 2023 Jul 31;262:115275. doi: 10.1016/j.ecoenv.2023.115275. Online ahead of print.ABSTRACTOzone (O3) is an important urban air pollutant having strong correlations with respiratory diseases. Several lines of evidence suggest that O3 exposure causes airway hyperresponsiveness (AHR) and pulmonary inflammation. Inhibitory innate immune receptors, such as NLRP12, have been demonstrated to alleviate inflammation, but the functional role for NLRP12 in O3-induced lung inflammatory inflammation remains to be reported. Here, we determined whether NLRP12 took a protective role in O3-induced AHR and pulmonary i...
Source: Ecotoxicology and Environmental Safety - August 2, 2023 Category: Environmental Health Authors: Mengyuan Li Yuan Xue Xinyi Miao Pengwei Ma Xiangbing Kong Yuefei Jin Yan Li Wei Wang Qiao Zhang Qihong Deng Feifei Feng Source Type: research
