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Infectious Disease: Adenoviruses
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18 β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription 3
CONCLUSION: 18β-GRA promotes the synthesis of autophagosomes and inhibits GC cell proliferation by regulating the miR-328-3p/STAT3 signaling pathway.PMID:37545635 | PMC:PMC10401664 | DOI:10.3748/wjg.v29.i27.4317
Source: World Journal of Gastroenterology : WJG - August 7, 2023 Category: Gastroenterology Authors: Yi Yang Yi Nan Yu-Hua Du Shi-Cong Huang Dou-Dou Lu Jun-Fei Zhang Xia Li Yan Chen Lei Zhang Ling Yuan Source Type: research
Clinical Efficacy and Safety of AdV-tk Gene Therapy for Patients with Cervical Squamous Intraepithelial Lesion: A Prospective Study
Hum Gene Ther. 2023 Aug 5. doi: 10.1089/hum.2023.066. Online ahead of print.ABSTRACTCervical cancer is the fourth most common type of cancer for women in 2020, and many more women have cervical pre-cancerous lesion-squamous intraepithelial lesion (SIL). Early treatment of cervical SIL to reverse or delay its progression is an important approach to reduce the incidence of cervical cancer. The efficacy and safety of adenovirus-based vectors expressing the thymidine kinase gene (AdV-tk) in the treatment of multiple types of cancers shows promise for its use in gynecology. We aim to provide relevant clinical efficacy and safet...
Source: Adv Data - August 5, 2023 Category: Epidemiology Authors: Nan Wang Xiulan Li Xin Liu Meina Bian Ying Hou Yuxiang Zhou Yanmei Li Fuqiang Xu Huadong Tang Ning Li Qing Liu Source Type: research
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Int Rev Cell Mol Biol. 2023;379:241-261. doi: 10.1016/bs.ircmb.2023.03.004. Epub 2023 Apr 1.ABSTRACTOncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here, we propose a set of selection criteria or ideal properties of a successful oncolytic virus, which include lack of pathogenic...
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Rupsa Basu Chad M Moles Source Type: research
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26.ABSTRACTHigh-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these tumors due to its oncolytic and immunostimulatory properties. Various oncolytic viruses, such as herpes simplex virus, adenov...
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Irati Herv ás-Corpión Marta M Alonso Source Type: research
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Int Rev Cell Mol Biol. 2023;379:241-261. doi: 10.1016/bs.ircmb.2023.03.004. Epub 2023 Apr 1.ABSTRACTOncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here, we propose a set of selection criteria or ideal properties of a successful oncolytic virus, which include lack of pathogenic...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Rupsa Basu Chad M Moles Source Type: research
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26.ABSTRACTHigh-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these tumors due to its oncolytic and immunostimulatory properties. Various oncolytic viruses, such as herpes simplex virus, adenov...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Irati Herv ás-Corpión Marta M Alonso Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Kenneth Lundstrom Source Type: research
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Int Rev Cell Mol Biol. 2023;379:241-261. doi: 10.1016/bs.ircmb.2023.03.004. Epub 2023 Apr 1.ABSTRACTOncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here, we propose a set of selection criteria or ideal properties of a successful oncolytic virus, which include lack of pathogenic...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Rupsa Basu Chad M Moles Source Type: research
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26.ABSTRACTHigh-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these tumors due to its oncolytic and immunostimulatory properties. Various oncolytic viruses, such as herpes simplex virus, adenov...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Irati Herv ás-Corpión Marta M Alonso Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research
