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Infectious Disease: Pandemics

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Total 137975 results found since Jan 2013.

"It's already stressful being a foster parent": A qualitative inquiry into foster parenting stress during COVID-19
CONCLUSIONS: Findings from this study demonstrated foster parents experienced both shared and unique parenting challenges during COVID-19. Three areas for further consideration and development in practice included improving online service delivery, strengthening guidance for online parent-child visitation, and enhancing support for foster parents of children with special needs. Developing social support and self-care practices should continue to be ongoing priorities for foster parents and foster parent-serving agencies.PMID:37717544 | DOI:10.1016/j.chiabu.2023.106455
Source: Child Abuse and Neglect - September 17, 2023 Category: Child Development Authors: Erin Findley Source Type: research

Building parameters linked with indoor transmission of SARS-CoV-2
Environ Res. 2023 Sep 15:117156. doi: 10.1016/j.envres.2023.117156. Online ahead of print.ABSTRACTThe rapid spread of Coronavirus Disease (2019)(COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emphasized the importance of understanding and adapting to the indoor remediation of transmissible diseases to decrease the risk for future pandemic threats. While there were many precautions in place to hinder the spread of COVID-19, there has also been a substantial increase of new research on SARS-CoV-2 that can be utilized to further mitigate the transmission risk of this novel virus. This r...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Jacqueline Horne Nicholas Dunne Nirmala Singh Md Safiuddin Navid Esmaeili Merve Erenler Ian Ho Edwin Luk Source Type: research

Oxygen therapy in patients with intermediate-risk acute pulmonary embolism: a randomized trial
Chest. 2023 Sep 15:S0012-3692(23)05431-4. doi: 10.1016/j.chest.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: The effect of supplemental oxygen therapy in patients with intermediate-risk pulmonary embolism (PE) who do not have hypoxemia at baseline is uncertain.RESEARCH QUESTION: Does supplemental oxygen improve echocardiographic parameters in non-hypoxemic patients with intermediate-risk PE?STUDY DESIGN AND METHODS: This pilot trial randomly assigned non-hypoxemic patients with stable PE and echocardiographic right ventricle (RV) enlargement to receive anticoagulation plus supplemental oxygen for the first 48 hour...
Source: Chest - September 17, 2023 Category: Respiratory Medicine Authors: Deisy Barrios Diego Dur án Carmen Rodr íguez Jorge Mois és Ana Retegui Jos é Luis Lobo Raquel L ópez Leyre Chasco Luis Jara-Palomares Alfonso Muriel Remedios Otero-Candelera Pedro Ruiz-Artacho Manuel Monreal Behnood Bikdeli David Jim énez AIR invest Source Type: research

Increased nationwide use of green spaces in Norway during the COVID-19 pandemic
Environ Int. 2023 Sep 11;180:108190. doi: 10.1016/j.envint.2023.108190. Online ahead of print.ABSTRACTIn recent years, there has been growing concern about the decline in human green space use and nature-based recreation in Western countries. While some evidence suggests that the COVID-19 pandemic led to increased recreational mobility in urban green spaces, it is unclear whether the pandemic led to nationwide changes in green space use in both densely and less densely populated neighborhoods, as well as whether social inequalities in green space use were reinforced or attenuated by the pandemic. To address these questions...
Source: Environment International - September 17, 2023 Category: Environmental Health Authors: Vidar Sandsaunet Ulset Zander Venter Michal Koz ák Emma Charlott Andersson Nordb ø Tilmann von Soest Source Type: research

Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research

Transcriptomic Analysis in Renal Cell Carcinoma and COVID-19 patients
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):156-162. doi: 10.14715/cmb/2023.69.8.24.ABSTRACTCOVID-19 pandemic poses a heavy risk upon global public health. The disease's severity and infection rate are high, especially among cancer patients. The current research was conducted to identify the most common biological pathways and how far they are associated with COVID-19 infection and clear cell renal cell carcinoma. In the current study, the authors analyzed the differentially expressed genes from the experimental and control groups with the help of the GEO2R tool. The study analyzed the protein-protein interactions th...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maha Abdulla Alwaili Source Type: research

Occurrence, formation, and proteins perturbation of disinfection byproducts in indoor air resulting from chlorine disinfection
This study highlights the potential secondary biological risk caused by intensive DBPs generated from chlorination and draws our attention to the potential environmental factors leading to chronic respiratory disease.PMID:37716567 | DOI:10.1016/j.chemosphere.2023.140182
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Yangwei Xiang Huan Xu Source Type: research

Tele-Neuropsychology: From Science to Policy to Practice
CONCLUSIONS: More studies of the reliability and validity of in-home tele-np-t using randomization methodology are necessary to support inclusion of tele-np-t codes on the CMS and CPT telehealth lists, and subsequently, the integration and delivery of in-home tele-np-t services across providers and institutions. These actions are needed to maintain equitable reimbursement of in-home tele-np-t services and address the widespread disparities in healthcare access.PMID:37715508 | DOI:10.1093/arclin/acad066
Source: Archives of Clinical Neuropsychology - September 16, 2023 Category: Psychiatry & Psychology Authors: Scott A Sperling Shawn K Acheson Joshua Fox-Fuller Mary K Colvin Lana Harder C Munro Cullum John J Randolph Kirstine R Carter Patricia Espe-Pfeifer Laura H Lacritz Peter A Arnett Stephen R Gillaspy Source Type: research

Review of the impact of the FDA's Fast Track Designation on biotechnology companies' share prices
This study examines the effect of the FDA's Fast Track Designation (FTD) on biotech company share prices. Using an event-study approach on 25 FTD announcements between June 2019 and June 2020, notable short- and long-term share price hikes were observed, with a 5-day cumulative average abnormal returns of 21.59%, 30-day at 38.34%, 1-year at 76.64% and 3-year at 111.37% against the XBI benchmark. These surges surpass prior research findings, indicating stronger investor reactions. The role of the COVID-19 pandemic as a confounder is discussed. Although the sample size is limited, the results offer valuable insights for inve...
Source: Drug Discovery Today - September 16, 2023 Category: Drugs & Pharmacology Authors: Joab Williamson Alexander James Spicer Source Type: research

Occurrence, formation, and proteins perturbation of disinfection byproducts in indoor air resulting from chlorine disinfection
This study highlights the potential secondary biological risk caused by intensive DBPs generated from chlorination and draws our attention to the potential environmental factors leading to chronic respiratory disease.PMID:37716567 | DOI:10.1016/j.chemosphere.2023.140182
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Yangwei Xiang Huan Xu Source Type: research

Transcriptomic Analysis in Renal Cell Carcinoma and COVID-19 patients
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):156-162. doi: 10.14715/cmb/2023.69.8.24.ABSTRACTCOVID-19 pandemic poses a heavy risk upon global public health. The disease's severity and infection rate are high, especially among cancer patients. The current research was conducted to identify the most common biological pathways and how far they are associated with COVID-19 infection and clear cell renal cell carcinoma. In the current study, the authors analyzed the differentially expressed genes from the experimental and control groups with the help of the GEO2R tool. The study analyzed the protein-protein interactions th...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Maha Abdulla Alwaili Source Type: research

Demographic and Geographic Characterization of Excess Mortality During the COVID-19 Pandemic in Baltimore City, MD, March 2020 - March 2021
Am J Epidemiol. 2023 Sep 15:kwad186. doi: 10.1093/aje/kwad186. Online ahead of print.ABSTRACTEstimates of excess mortality can provide insight into direct and indirect impacts of the COVID-19 pandemic beyond deaths specifically attributed to COVID-19. We analyzed death certificate data from Baltimore City, Maryland from March 1, 2020 to March 31, 2021 and found that 1,725 individuals (95% confidence interval, 1,495-1,954) died in excess of what was expected from all-cause mortality trends in 2016-2019. 1,050 (61%) excess deaths were attributed to COVID-19. Observed mortality was 23-32% higher than expected among individual...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Kyle T Aune Kyra H Grantz Neia Prata Menezes Katherine O Robsky Emily S Gurley Melissa A Marx Darcy F Phelan-Emrick Source Type: research

Ethical Requirements for Human Challenge Studies: A Systematic Review of Reasons
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3054. Online ahead of print.ABSTRACTHuman challenge studies (HCS) are controlled clinical trials in which participants are deliberately infected with a pathogen. Such trials are being developed for an increasing number of diseases. Partly as a result of the COVID-19 pandemic, there has been a recent ethical debate about the reasons for and against HCS in general, or rather, about the requirements that individual HCS must fulfill to be ethically acceptable. A systematic review was conducted to categorize and summarize such requirements and the reasons given for them. Ethics...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Matthias Katzer Sabine Salloch Christoph Schindler Marcel Mertz Source Type: research

Demographic and Geographic Characterization of Excess Mortality During the COVID-19 Pandemic in Baltimore City, MD, March 2020 - March 2021
Am J Epidemiol. 2023 Sep 15:kwad186. doi: 10.1093/aje/kwad186. Online ahead of print.ABSTRACTEstimates of excess mortality can provide insight into direct and indirect impacts of the COVID-19 pandemic beyond deaths specifically attributed to COVID-19. We analyzed death certificate data from Baltimore City, Maryland from March 1, 2020 to March 31, 2021 and found that 1,725 individuals (95% confidence interval, 1,495-1,954) died in excess of what was expected from all-cause mortality trends in 2016-2019. 1,050 (61%) excess deaths were attributed to COVID-19. Observed mortality was 23-32% higher than expected among individual...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Kyle T Aune Kyra H Grantz Neia Prata Menezes Katherine O Robsky Emily S Gurley Melissa A Marx Darcy F Phelan-Emrick Source Type: research