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Infectious Disease: Pandemics

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Total 137975 results found since Jan 2013.

Job search self-regulation during COVID-19: Linking search constraints, health concerns, and invulnerability to job search processes and outcomes.
The COVID-19 pandemic has caused tremendous job loss and made it difficult for unemployed individuals to search for new jobs. Specifically, the pandemic has created numerous job search obstacles, such as increased childcare and community responsibilities, that interfere with job seekers’ ability to search for a job. Yet, the job search literature has scantily examined the implications of such job search constraints for job seekers even in normal times, and the limited studies that do exist have produced mostly null findings. Drawing from self-regulation theories, we position COVID-19 job search constraints as a catalyst ...
Source: Journal of Applied Psychology - August 12, 2021 Category: Psychiatry & Psychology Source Type: research

Scoping Review on Search Queries and Social Media for Disease Surveillance: A Chronology of Innovation
Conclusions: The use of search queries and social media for disease surveillance are relatively recent phenomena (first reported in 2006). Both the tools themselves and the methodologies for exploiting them are evolving over time. While their accuracy, speed, and cost compare favorably with existing surveillance systems, the primary challenge is to refine the data signal by reducing surrounding noise. Further developments in digital disease surveillance have the potential to improve sensitivity and specificity, passively through advances in machine learning and actively through engagement of users. Adoption, even as suppor...
Source: Journal of Medical Internet Research - July 18, 2013 Category: Journals (General) Authors: Theresa Marie BernardoAndrijana RajicIan YoungKatie RobiadekMai T PhamJulie A Funk Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research

Bifunctional siRNA containing immunostimulatory motif 2 enhances protection against pandemic H1N1 virus infection.
CONCLUSIONS: This study paves the way for broad-spectrum RNAi-based therapeutics using immunostimulatory motif towards improved antiviral effect. Hence this approach will be useful to confront the sudden emergence of pandemic strains. PMID: 26264705 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - August 12, 2015 Category: Genetics & Stem Cells Authors: Joshi G, Dash PK, Agarwal A, Sharma S, Parida M Tags: Curr Gene Ther Source Type: research

A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2.
Abstract An outbreak, caused by an RNA virus, SARS-CoV-2 named COVID-19 has become pandemic with a magnitude which is daunting to all public health institutions in the absence of specific antiviral treatment. Surface glycoprotein and nucleocapsid phosphoprotein are two important proteins of this virus facilitating its entry into host cell and genome replication. Small interfering RNA (siRNA) is a prospective tool of the RNA interference (RNAi) pathway for the control of human viral infections by suppressing viral gene expression through hybridization and neutralization of target complementary mRNA. So, in this stu...
Source: Genomics - December 12, 2020 Category: Genetics & Stem Cells Authors: Chowdhury UF, Shohan MUS, Hoque KI, Beg MA, Siam MKS, Moni MA Tags: Genomics Source Type: research

Optimised design of siRNA based on multi-featured comparison and analysis of H1N1 virus.
In this study, we developed a computational method for designing therapeutics siRNA and applied in the recent HIN1 influenza virus based on its biological characteristics that are substantially different from seasonal influenza virus. We first compared the PA fragments between the H IN1 virus in 2009 and the seasonal influenza virus genes in 2008, and the comparison found significant differences between them not only in sequence features but also in RNA secondary structures. In particular, the RNA secondary structures only share 76.8% identity, which suggests major changes in biological characteristics. Furthermore, we des...
Source: International Journal of Data Mining and Bioinformatics - June 29, 2013 Category: Bioinformatics Authors: Liu Y, Chang Y, Xu D, Li Z, Zhang H, Li J, Tian M Tags: Int J Data Min Bioinform Source Type: research

Aptamer-siRNA Chimeras for HIV.
Authors: Takahashi M, Burnett JC, Rossi JJ Abstract Since 1980s, HIV/AIDS has escalated into a global pandemic. Although combinatorial antiretroviral therapy (cART) regimens can suppress plasma virus levels to below the detection limit and the survival rate of HIV-1 infected patients has been improving, long-term cART holds the potential to cause a number of chronic diseases. RNA interference (RNAi) is considered as a powerful method for developing new generation of therapeutics. Discovery of small interfering RNAs (siRNAs) shed light on limitations of targets that are "undruggable" with current technologies. Howev...
Source: Advances in Experimental Medicine and Biology - March 12, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Public interest in musculoskeletal symptoms and disorders during the COVID-19 pandemic : Infodemiology study
CONCLUSION: Public interest focused on COVID-19 and sought online information for COVID-19 symptoms in the early pandemic. In the period July through October, there was an upward trend in musculoskeletal symptoms and some colloquial terms/well-known musculoskeletal conditions coupled with a downward trend in general musculoskeletal disorder terms and certain specific diagnoses. This information may help rheumatologists understand public interest in musculoskeletal symptoms and disorders and address the needs of patients to mitigate the negative impact of the pandemic on outcomes.PMID:33779835 | PMC:PMC8006118 | DOI:10.1007/s00393-021-00989-2
Source: Zeitschrift fur Rheumatologie - March 29, 2021 Category: Rheumatology Authors: Sinan Karde ş An ıl Erdem Hatice G ürdal Source Type: research