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Drug: Medroxyprogesterone
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Total 487 results found since Jan 2013.
Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD
Clin Immunol. 2023 Sep 1:109750. doi: 10.1016/j.clim.2023.109750. Online ahead of print.ABSTRACTAlthough effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcript...
Source: Clinical Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Prachi Mehrotra Gupta Christina Balle Gregory K Tharp Sydney A Nelson Melanie A Gasper Bryan Brown Arghavan Alisoltani Maricianah Onono Thesla Palanee-Phillips Gonsagrie Nair Hosseana Ayele Laura Noel-Romas Jo-Ann S Passmore Adam D Burgener Renee Heffron Source Type: research
Efficacy and prognosis of adjuvant treatment of endometrial cancer with medroxyprogesterone acetate COX regression analysis
CONCLUSION: Age, pathological type, molecular typing, and myometrial infiltration were all relevant factors affecting the prognosis of early-stage high-risk endometrial cancer. The potential long-term prognostic benefit of adjuvant postoperative radiotherapy in patients with early-stage high-risk endometrial cancer is worthy of clinical consideration.PMID:37637703 | PMC:PMC10450383 | DOI:10.12998/wjcc.v11.i23.5447
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Ding-Ran Wang Source Type: research
Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
CONCLUSIONS: Administration of JP combined with MPA restores tumor-induced cachexia conditions. In addition, the profound effect of JP combined with MPA on tumor-induced cachexia may be due to its inhibition of muscle proteolysis (E3 ubiquitinase system).PMID:37612478 | DOI:10.1007/s11655-023-3702-4
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Qi Li Zhao-di Kong Huan Wang Hong-Hui Gu Zhong Chen Shi-Guang Li Yi-Qi Chen Yu Cai Zhen-Jiang Yang Source Type: research
Comparison of Thromboembolism Outcomes in Patients with Sickle Cell Disease Prescribed Hormonal Contraception
This study aims to assess patterns of hormonal contraceptive use and compare risk of contraception-related TE between combined hormonal contraceptives (CHC) and progestin-only contraceptives (POC). Patients with SCD between 12-44 years with a new prescription of a hormonal contraceptive in the CMS MAX database (2006-2018) were followed for one year. Cox regression analysis was used to calculate the hazard ratio (HR) of TE. We identified 7,173 new users: 44.6% initiated CHC and 55.4% initiated POC. Combined oral contraceptive pills (OCP) (36.5%) and progestin-only depot medroxyprogesterone acetate (33.9%) were the most freq...
Source: Adv Data - August 16, 2023 Category: Epidemiology Authors: Natasha S Bala Joseph R Stanek Sara K Vesely Robert M Cronin Susan E Creary Andrea H Roe Wendy Xu Sarah H O'Brien Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
