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Total 487 results found since Jan 2013.
Characterization of GAB1 expression over the menstrual cycle in women with and without Polycystic Ovarian Syndrome provides a new insight into its pathophysiology.
Conclusions: GAB1 mRNA expression is positively modulated by E2. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation.
PMID: 25144631 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 21, 2014 Category: Endocrinology Authors: Roemer KL, Young SL, Savaris RF Tags: J Clin Endocrinol Metab Source Type: research
GR-mediated Regulation of Cytokine Genes by MPA Signal Transduction
This study shows that P4 and MPA significantly increase the expression of the IL-12p40 and IL-12p35 genes, whereas IL-10 gene expression is suppressed in a dose-dependent manner. Moreover, these effects were abrogated when reducing the glucocorticoid receptor (GR) levels with siRNA. Using a combination of chromatin immunoprecipitation (ChIP), siRNA, and re-ChIP assays, we show that recruitment of the P4- and MPA-bound GR to the IL-12p40 promoter requires CCAAT enhancer-binding protein (C/EBP)-β and nuclear factor κB (NFκB), although recruitment to the IL-10 promoter requires signal transducer and activator of transcript...
Source: Journal of Biological Chemistry - November 6, 2014 Category: Chemistry Authors: Louw-du Toit, R., Hapgood, J. P., Africander, D. Tags: Gene Regulation Source Type: research
Removal of REV-ERBα inhibition contributes to the prostaglandin G/H synthase 2 expression in rat endometrial stromal cells.
This study focused on Ptgs2, which is essential for decidualization, as a putative clock-controlled gene, and aimed to reveal the functions of clock genes in relation to Ptgs2 during decidualization. We compared the transcript levels of clock genes in the rat uterus on days 4.5 (D4.5) and 6.5 of pregnancy. The transcript levels of clock genes (Per2, Bmal1, Rorα and Rev-erbα) had decreased at implantation sites on day 6.5 (D6.5e) compared to those on D4.5, while Ptgs2 transcripts had increased on D6.5e. Similar observations of REV-ERBα and PTGS2 were also obtained in the endometrium on D6.5e by immunohistochemistry. In t...
Source: Physiological Reviews - February 3, 2015 Category: Physiology Authors: Isayama K, Zhao L, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA Tags: Am J Physiol Endocrinol Metab Source Type: research
Removal of Rev-erb{alpha} inhibition contributes to the prostaglandin G/H synthase 2 expression in rat endometrial stromal cells
This study focused on Ptgs2, which is essential for decidualization, as a putative clock-controlled gene, and aimed to reveal the functions of clock genes in relation to Ptgs2 during decidualization. We compared the transcript levels of clock genes in the rat uterus on days 4.5 (D4.5) and 6.5 of pregnancy. The transcript levels of clock genes (Per2, Bmal1, Rorα, and Rev-erbα) had decreased at implantation sites on day 6.5 (D6.5e) compared with those on D4.5, whereas Ptgs2 transcripts had increased on D6.5e. Similar observations of Rev-erbα and Ptgs2 were also obtained in the endometrium on D6.5e by immuno...
Source: AJP: Endocrinology and Metabolism - April 15, 2015 Category: Endocrinology Authors: Isayama, K., Zhao, L., Chen, H., Yamauchi, N., Shigeyoshi, Y., Hashimoto, S., Hattori, M.-a. Tags: Articles Source Type: research
GSE200312 Glucocorticoid recptor knockdown in primary amnion epithelial cells treated with MPA and TNFa
Contributors : Sarah J Cunningham ; Terrence K Allen ; Tim E Reddy ; Alejandro BarreraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo analyze the effect of glucocorticoids on primary amnion epthelial cells, we harvested tissue samples from 10 healthy ceseaean section patients. We knocked down the glucocorticoid receptor with an siRNA or used a control siRNA. We treated samples with medroxyprogesterone acetate. Half the cells we subjected to a TNFa challenge
Source: GEO: Gene Expression Omnibus - April 9, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Matrix Metalloproteinases in Human Decidualized Endometrial Stromal Cells
Curr Issues Mol Biol. 2021 Nov 26;43(3):2111-2123. doi: 10.3390/cimb43030146.ABSTRACTCyclic changes, such as growth, decidualization, shedding, and regeneration, in the human endometrium are regulated by the reciprocal action of female hormones, such as estradiol (E2), and progesterone (P4). Matrix metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs) control the invasion of extravillous trophoblast cells after implantation. Several MMPs and TIMPs function in the decidua and endometrial stromal cells (ESCs). Here, we aimed to systematically investigate the changes in MMPs and TIMPs associated with ESC decidualizati...
Source: Current Issues in Molecular Biology - December 23, 2021 Category: Molecular Biology Authors: Yoji Hisamatsu Hiromi Murata Hiroaki Tsubokura Yoshiko Hashimoto Masaaki Kitada Susumu Tanaka Hidetaka Okada Source Type: research
