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Drug: Medroxyprogesterone
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Total 487 results found since Jan 2013.
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
Fertility-sparing hormonal treatment in patients with stage I endometrial cancer of grade 2 without myometrial invasion and grade 1-2 with superficial myometrial invasion: Gynecologic Oncology Research Investigators coLLaborAtion study (GORILLA-2001)
CONCLUSION: The overall response rate to FST was promising, however, the PD rate was significant during the first 12 months of FST. Therefore, performing thorough endometrial biopsy and imaging studies is essential to strictly evaluate the extent of the disease every 3 months from FST initiation.PMID:37172410 | DOI:10.1016/j.ygyno.2023.04.027
Source: Gynecologic Oncology - May 12, 2023 Category: Cancer & Oncology Authors: A Jin Lee Eun Jung Yang Nam Kyeong Kim Yeorae Kim Dong Hoon Suh Jeeyeon Kim Joo-Hyuk Son Tae-Wook Kong Suk-Joon Chang Dong Won Hwang Soo Jin Park Hee Seung Kim Ji Geun Yoo Sung Jong Lee Yoo-Young Lee Seung-Hyuk Shim Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
CONCLUSIONS: This study illustrates that SRARP exerts a tumor-suppressive effect by inhibiting the epithelial-mesenchymal transition via Wnt signaling in EC. In addition, SRARP positively modulates PR expression and interacts with PR to regulate PR downstream target genes.PMID:37144734 | DOI:10.1097/CM9.0000000000002537
Source: Chinese Medical Journal - May 5, 2023 Category: General Medicine Authors: Jie Liu Zhiqi Wang Jingyi Zhou Jiaqi Wang Xiangjun He Jianliu Wang Source Type: research
Evaluations of memory, anxiety, and the growth factor IGF-1R after post-surgical menopause treatment with a highly selective progestin
Behav Brain Res. 2023 Apr 19:114442. doi: 10.1016/j.bbr.2023.114442. Online ahead of print.ABSTRACTProgestogens are a key component of menopausal hormone therapies. While some progestogens can be detrimental to cognition, there is preclinical evidence that progestogens with a strong progesterone-receptor affinity benefit some molecular mechanisms believed to underlie cognitive function. Thus, a progestin that maximizes progesterone-receptor affinity and minimizes affinities to other receptors may be cognitively beneficial. We evaluated segesterone-acetate (SGA), a 19-norprogesterone derivative with a strong progesterone-re...
Source: Behavioural Brain Research - April 19, 2023 Category: Neurology Authors: Victoria E Bernaud Stephanie V Koebele Steven N Northup-Smith Mari N Willeman Charlotte Barker Alex Schatzki-Lumpkin Maria Valenzuela Sanchez Heather A Bimonte-Nelson Source Type: research
