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Cancer: Liver Cancer
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Total 31222 results found since Jan 2013.
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
Involvement of proliferation of atypical hepatocytes and CDT 1 in the liver cancer of rats administered the diethylnitrosamine
J Clin Biochem Nutr. 2023 Sep;73(2):138-144. doi: 10.3164/jcbn.13-16. Epub 2023 Sep 1.ABSTRACTWe have reported that extent of proliferation of atypical hepatocytes (POAH) in non-cancerous liver in hepatocellular carcinoma and chromatin licensing and DNA replication factor 1 (CDT1) are associated with postoperative recurrence. Here, we investigated whether extent of POAH and expression of CDT1 in liver are also associated with chemically induced liver cancer in rats. Male Fisher strain rats were orally administered diethylnitrosamine (DEN) in their drinking water and sacrificed at 6, 8, 12, or 14 weeks after start of DEN ad...
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Masahiro Ogawa Ryota Masuzaki Tatsuo Kanda Hiroshi Matsumura Hitomi Nakamura Motomi Yamazaki Toshikatu Shibata Hirofumi Kogure Mitsuhiko Moriyama Source Type: research
Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma
This study aimed to examine the clinical and prognostic significance of cell-cycle progression gene 1 (CCPG1) in hepatocellular carcinoma (HCC). We firstly analyzed CCPG1 expression in various cancers using The Cancer Genome Atlas and the Genotype-Tissue Expression project databases. The relative expression levels of CCPG1 were determined in 164 paired HCC and adjacent tissues using immunohistochemistry. The correlation between CCPG1 and clinicopathological characteristics of HCC was analyzed. Cox proportional models were used to identify the prognostic factors for overall survival (OS) and disease-free survival (DFS). The...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Gangpu Wang Zhiqian Liu Qi Wang Bingqi Liu Jie Li Source Type: research
Ablative margins in percutaneous thermal ablation of hepatic tumors: a systematic review
CONCLUSIONS: Current evidence supports AM > 5 mm to reduce the risk of LTP after thermal ablation of HCC and CRLM. However, standardization of AM measurement and reporting is critical to allow future meta-analyses and improved identification of optimal threshold value for clinical use.PMID:37702571 | DOI:10.1080/14737140.2023.2247564
Source: Expert Review of Anticancer Therapy - September 13, 2023 Category: Cancer & Oncology Authors: K H M Verdonschot S Arts P B Van den Boezem J H W de Wilt J J F ütterer M W J Stommel C G Overduin Source Type: research
Validation of the albumin-bilirubin score for identifying decompensation risk in patients with compensated cirrhosis
CONCLUSION: The ALBI score accurately identifies decompensation risk at the 3-year follow-up in patients with compensated cirrhosis. Those cirrhotic patients with a high-risk grade of ALBI score showed a 23 times greater odds of decompensation.PMID:37701131 | PMC:PMC10494764 | DOI:10.3748/wjg.v29.i32.4873
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Huttakan Navadurong Kessarin Thanapirom Salisa Wejnaruemarn Thaninee Prasoppokakorn Roongruedee Chaiteerakij Piyawat Komolmit Sombat Treeprasertsuk Source Type: research
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC
Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13.ABSTRACTThe incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor. There are no approved treatments to treat NASH. Here, we first used single-nucleus RNA sequencing to characterize a mouse model that mimics human NASH-driven HCC, the MUP-uPA mouse fed a high-fat diet. Activation of endoplasmic reticulum (ER) stress and inflammation was observed in a subset of hepatocytes that was enriched in mice that progress to HCC. We next ...
Source: Adv Data - September 13, 2023 Category: Epidemiology Authors: Ebru Boslem Saskia Reibe Rodrigo Carlessi Benoit Smeuninx Surafel Tegegne Casey L Egan Emma McLennan Lauren V Terry Max Nobis Andre Mu Cameron Nowell Neil Horadagoda Natalie A Mellett Paul Timpson Matthew Jones Elena Denisenko Alistair R R Forrest Janina Source Type: research
Improving diverse participation in cancer clinical trials
Trans Am Clin Climatol Assoc. 2023;133:149-156.ABSTRACTDespite significant improvement in overall cancer mortality (>30% since 1991), these survival benefits have not been experienced by all groups uniformly especially in those of diverse heritage. Drivers of cancer health inequity are multi-factorial including more adverse social determinants of health, later stage cancer presentation, decreased health care access, decreased health literacy, and cultural barriers to prompt cancer care. Adding to these disparities is the historical inclusion of primarily well-insured Caucasian patients into cancer clinical trials leadin...
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Ruben Mesa Rebecca T Jones Source Type: research
Validation of the albumin-bilirubin score for identifying decompensation risk in patients with compensated cirrhosis
CONCLUSION: The ALBI score accurately identifies decompensation risk at the 3-year follow-up in patients with compensated cirrhosis. Those cirrhotic patients with a high-risk grade of ALBI score showed a 23 times greater odds of decompensation.PMID:37701131 | PMC:PMC10494764 | DOI:10.3748/wjg.v29.i32.4873
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Huttakan Navadurong Kessarin Thanapirom Salisa Wejnaruemarn Thaninee Prasoppokakorn Roongruedee Chaiteerakij Piyawat Komolmit Sombat Treeprasertsuk Source Type: research
Involvement of proliferation of atypical hepatocytes and CDT 1 in the liver cancer of rats administered the diethylnitrosamine
J Clin Biochem Nutr. 2023 Sep;73(2):138-144. doi: 10.3164/jcbn.13-16. Epub 2023 Sep 1.ABSTRACTWe have reported that extent of proliferation of atypical hepatocytes (POAH) in non-cancerous liver in hepatocellular carcinoma and chromatin licensing and DNA replication factor 1 (CDT1) are associated with postoperative recurrence. Here, we investigated whether extent of POAH and expression of CDT1 in liver are also associated with chemically induced liver cancer in rats. Male Fisher strain rats were orally administered diethylnitrosamine (DEN) in their drinking water and sacrificed at 6, 8, 12, or 14 weeks after start of DEN ad...
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Masahiro Ogawa Ryota Masuzaki Tatsuo Kanda Hiroshi Matsumura Hitomi Nakamura Motomi Yamazaki Toshikatu Shibata Hirofumi Kogure Mitsuhiko Moriyama Source Type: research
Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Ablative margins in percutaneous thermal ablation of hepatic tumors: a systematic review
CONCLUSIONS: Current evidence supports AM > 5 mm to reduce the risk of LTP after thermal ablation of HCC and CRLM. However, standardization of AM measurement and reporting is critical to allow future meta-analyses and improved identification of optimal threshold value for clinical use.PMID:37702571 | DOI:10.1080/14737140.2023.2247564
Source: Expert Review of Anticancer Therapy - September 13, 2023 Category: Cancer & Oncology Authors: K H M Verdonschot S Arts P B Van den Boezem J H W de Wilt J J F ütterer M W J Stommel C G Overduin Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
Apoptin and apoptotic protease-activating factor 1 plasmid-assisted multi-functional nanoparticles in hepatocellular carcinoma therapy
Int J Biol Macromol. 2023 Sep 11:126870. doi: 10.1016/j.ijbiomac.2023.126870. Online ahead of print.ABSTRACTCancer drugs usually have side effects in chemotherapy. Apoptin, a protein recognized by its good therapeutical effect on tumors and innocuous to body, is employed to treat hepatocellular carcinoma (HCC). As our previous data shown, the efficiency of apoptin protein might be limited by the protein of apaf-1. Therefore, we designed the multi-functional nanoparticles (MFNPs) encapsulating apoptin and apaf-1 plasmids by layer-by layer assembly. The NPs could release drugs into tumor site specifically and had good compat...
Source: International Journal of Biological Macromolecules - September 13, 2023 Category: Biochemistry Authors: Jiawei Zhang Tiantian Guo Xinyi Liu Shuyue Guo Yao Wang Baokuan Zhu Meiling Zhang Xiujun Gao Jingyu Wang Source Type: research
