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Total 31222 results found since Jan 2013.
LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis
In this study, LOXL1-AS1 was overexpressed in HCC cell lines, and LOXL1-AS1 knockdown repressed cell proliferation and stimulated apoptosis in HCC. Besides, the activating role of LOXL1-AS1 in the AKT pathway was also confirmed. Further, miR-1224-5p was sponged by LOXL1-AS1, and overexpression exerted inhibitory function in HCC. Moreover, ITPRIPL2 as amiR-1224-5ptarget gene. Meanwhile, ITPRIPL2 deficiency suppressed HCC cell proliferation. Finally, miR-1224-5p inhibitor reversed the hindering role of LOXL1-AS1 depletion in HCC cell proliferation and AKT pathway, and this rescuing effect was offset by ITPRIPL2 silencing. In...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tangen Chen Shuyun Zeng Quanyuan Liu Yufeng Chen Junjiang Lu Source Type: research
MicroRNAs and their vital role in apoptosis in hepatocellular carcinoma: miRNA-based diagnostic and treatment methods
Gene. 2023 Sep 14;888:147803. doi: 10.1016/j.gene.2023.147803. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most prevalent malignancies with high invasive and metastatic capability. Although significant advances have been made in the treatment of HCC, the overall survival rate of patients is still low. It is essential to explore accurate biomarkers for early diagnosis and prognosis along with therapeutic procedures to increase the survival rate of these patients. Anticancer therapies can contribute to induce apoptosis for the elimination of cancerous cells. However, dysregulated apoptosis and ...
Source: Gene - September 16, 2023 Category: Genetics & Stem Cells Authors: Masoumeh Hajizadeh Farnaz Hajizadeh Sevil Ghaffarei Mohammad Amin Doustvandi Khadijeh Hajizadeh Seyyed Mohammad Yaghoubi Fateme Mohammadnejad Nadia Allahyarzadeh Khiabani Pegah Mousavi Behzad Baradaran Source Type: research
MicroRNAs and their vital role in Apoptosis in Hepatocellular carcinoma: miRNA-based diagnostic and treatment methods
Gene. 2023 Sep 14:147803. doi: 10.1016/j.gene.2023.147803. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most prevalent malignancies with high invasive and metastatic capability. Although significant advances have been made in the treatment of HCC, the overall survival rate of patients is still low. It is essential to explore accurate biomarkers for early diagnosis and prognosis along with therapeutic procedures to increase the survival rate of these patients. Anticancer therapies can contribute to induce apoptosis for the elimination of cancerous cells. However, dysregulated apoptosis and prol...
Source: Gene - September 16, 2023 Category: Genetics & Stem Cells Authors: Masoumeh Hajizadeh Farnaz Hajizadeh Sevil Ghaffarei Mohammad Amin Doustvandi Khadijeh Hajizadeh Seyyed Mohammad Yaghoubi Fateme Mohammadnejad Nadia Allahyarzadeh Khiabani Pegah Mousavi Behzad Baradaran Source Type: research
Simultaneous quantification of Gadoxetic acid and Cisplatin in hepatocellular carcinomas using laser ablation-inductively coupled plasma-mass spectrometry
Metallomics. 2023 Sep 15:mfad052. doi: 10.1093/mtomcs/mfad052. Online ahead of print.ABSTRACTThe gadolinium-based contrast agent Gadoxetic acid and the platinum-based anti-tumor agent Cisplatin were quantitatively imaged in liver and liver cancer (hepatocellular carcinoma, HCC) tissue of rats by means of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). HCC bearing rats simultaneously received a tail vein injection of the hepatocyte-specific magnetic resonance imaging contrast agent Gadoxetic acid and a transarterial injection of Cisplatin 15 min before sacrifice and liver removal. Resecting HCC with...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Katharina Kronenberg Julia Werner Peter Bohrer Katja Steiger Rebecca Buchholz Maximilian von Bremen-K ühne Matthias Elinkmann Philipp M Paprottka Rickmer F Braren Fabian K Loh öfer Uwe Karst Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway
Ecotoxicol Environ Saf. 2023 Sep 14;264:115478. doi: 10.1016/j.ecoenv.2023.115478. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is considered the most toxic carcinogenic compound, and exposure to AFB1 is highly associated with hepatocellular carcinoma. The aim of this study was to investigate the effects of different doses of AFB1 on growth performance and the liver of rabbits, as well as explore its underlying mechanisms. A total of eighty 30-day-old meat rabbits were randomly divided into four treatments. The control group was fed a pollution-free diet, while the AFL, AFM, and AFH groups were fed contaminated diets ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Lu Zhang Shaowen Shi Ying Liu Yuqing Cui Yixuan Zhu Yongzhan Bao Baojiang Chen Wanyu Shi Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis
In this study, LOXL1-AS1 was overexpressed in HCC cell lines, and LOXL1-AS1 knockdown repressed cell proliferation and stimulated apoptosis in HCC. Besides, the activating role of LOXL1-AS1 in the AKT pathway was also confirmed. Further, miR-1224-5p was sponged by LOXL1-AS1, and overexpression exerted inhibitory function in HCC. Moreover, ITPRIPL2 as amiR-1224-5ptarget gene. Meanwhile, ITPRIPL2 deficiency suppressed HCC cell proliferation. Finally, miR-1224-5p inhibitor reversed the hindering role of LOXL1-AS1 depletion in HCC cell proliferation and AKT pathway, and this rescuing effect was offset by ITPRIPL2 silencing. In...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tangen Chen Shuyun Zeng Quanyuan Liu Yufeng Chen Junjiang Lu Source Type: research
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway
Ecotoxicol Environ Saf. 2023 Sep 14;264:115478. doi: 10.1016/j.ecoenv.2023.115478. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is considered the most toxic carcinogenic compound, and exposure to AFB1 is highly associated with hepatocellular carcinoma. The aim of this study was to investigate the effects of different doses of AFB1 on growth performance and the liver of rabbits, as well as explore its underlying mechanisms. A total of eighty 30-day-old meat rabbits were randomly divided into four treatments. The control group was fed a pollution-free diet, while the AFL, AFM, and AFH groups were fed contaminated diets ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Lu Zhang Shaowen Shi Ying Liu Yuqing Cui Yixuan Zhu Yongzhan Bao Baojiang Chen Wanyu Shi Source Type: research
Oncogenic pathways refine a new perspective on the classification of hepatocellular carcinoma
CONCLUSIONS: ADP provides a new perspective for identifying patients at high risk of recurrence and could optimize precision treatment to improve the clinical outcomes in HCC.PMID:37714446 | DOI:10.1016/j.cellsig.2023.110890
Source: Cellular Signalling - September 15, 2023 Category: Cytology Authors: Yuyuan Zhang Zaoqu Liu Jie Li Bailu Wu Xin Li Mengjie Duo Hui Xu Long Liu Xiaoxing Su Xuhua Duan Peng Luo Jian Zhang Zhen Li Source Type: research
TMEM64 is highly expressed in hepatocellular carcinoma and promotes tumor cell proliferation and invasion
CONCLUSION: A high TMEM64 expression may serve as an independent risk factor for poor prognosis of HCC and promotes proliferation, migration, and invasion of HCC cells in vitro.PMID:37712271 | DOI:10.12122/j.issn.1673-4254.2023.08.11
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: D Cao J Cai Y Li R Dong Z Wang X Zuo Source Type: research
Dealcoholized red wine inhibits occurrence and progression of hepatocellular carcinoma possibly by inducing cell cycle arrest and apoptosis
CONCLUSION: DRW inhibits the occurrence and progression of HCC, and this effect is mediated possibly by inducing cell cycle arrest and apoptosis.PMID:37712265 | DOI:10.12122/j.issn.1673-4254.2023.08.05
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Y Lan K Wang Z Lan H Zhou J Sun Source Type: research
Albumin nanoparticles and their folate modified counterparts for delivery of a lupine derivative to hepatocellular carcinoma
In conclusion, functionalized nanoparticles (FA-PEG-CTr-NPs) can specifically inhibit the malignant proliferation of HCC cells and are thus a promising nanoagent for the treatment of HCC.PMID:37713994 | DOI:10.1016/j.biopha.2023.115485
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Haohao Wang Di Wu Pan Wang Chunyu Gao Hongbo Teng Dong Liu Yan Zhao Rui Du Source Type: research
Preservation of circadian rhythm in hepatocellular cancer
J Biol Chem. 2023 Sep 13:105251. doi: 10.1016/j.jbc.2023.105251. Online ahead of print.ABSTRACTCircadian rhythms are controlled at the cellular level by a molecular clock consisting of several genes/proteins engaged in a transcription-translation-degradation feedback loop. These core clock proteins regulate thousands of tissue-specific genes. Regarding circadian control in neoplastic tissues, reports to date have demonstrated anomalous circadian function in tumor models and cultured tumor cells. We have extended these studies by analyzing circadian rhythmicity genome-wide in a mouse model of liver cancer, in which mice tre...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Yanyan Yang Ashraf N Abdo Hiroaki Kawara Christopher P Selby Aziz Sancar Source Type: research
Resveratrol Inhibits Hepatocellular Carcinoma Progression Through Regulating Exosome Secretion
CONCLUSION: Resveratrol inhibits hepatocellular carcinoma progression by regulating exosome secretion and contents.PMID:37711128 | DOI:10.2174/0929867331666230914090053
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Kun Tong Pingfeng Wang Ying Li Yaoyao Tong Xuejie Li Shirong Yan Pei Hu Source Type: research
