Filtered By:
Therapy: Hormonal Therapy

This page shows you your search results in order of date.

Order by Relevance | Date

Total 24 results found since Jan 2013.

The effect of silencing the Tip60 gene on the response to radiotherapy in breast cancer cells
In this study, for the first time, the role of the silenced and active Tip60 gene in response to radiotherapy in MDA-MB-231 and MCF-7 cells was investigated. For this purpose, the Tip60 gene was silenced by applying siRNA to the cell lines and UV was applied. In the study, cytotoxicity and DNA breaks were measured by MTT and COMET methods, and mRNA and protein expression values were measured by PCR and Raman spectrophotometer in silenced, unsilenced, UV-treated, and non-UV-treated cell lines. According to the results of the study, increased DNA damage was observed in MCF-7 cell lines in which the Tip60 gene was silenced, a...
Source: Breast - April 17, 2023 Category: Cancer & Oncology Authors: Ece Miser-Saliho ğlu Bensu Karahalil Meri ç Arda Eşmakaya U ğur Tamer Sevgi Yardim-Akaydin Source Type: research

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer
We examined paired tissues from Taiwanese patients and observed that 65.09% and 68.25% of patients exhibited TSTD1 hypomethylation and overexpression, respectively. A significant correlation was found between TSTD1 hypomethylation and overexpression in Taiwanese (74.2%, p = 0.040) and Western (88.0%, p < 0.001) cohorts. High expression of TSTD1 protein was observed in 68.8% of Taiwanese and Korean breast cancer patients. Overexpression of TSTD1 in tumors of breast cancer patients was significantly associated with poor 5-year overall survival (p = 0.021) and poor chemotherapy response (p = 0.008). T47D cells treated with...
Source: Frontiers in Oncology - November 7, 2022 Category: Cancer & Oncology Source Type: research

The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options
AbstractHormonal therapy plays a vital part in the treatment of estrogen receptor –positive (ER +) breast cancer. ER can be activated in a ligand-dependent and independent manner. Currently available ER-targeting agents include selective estrogen receptor modulators (SERMs), selective estrogen receptor degraders (SERDs), and aromatase inhibitors (AIs). Estrogen receptor mutat ion (ESR1 mutation) is one of the common mechanisms by which breast cancer becomes resistant to additional therapies from SERMs or AIs. These tumors remain sensitive to SERDs such as fulvestrant. Fulvestrant is limited in clinical utilization by i...
Source: Cancer and Metastasis Reviews - October 14, 2022 Category: Cancer & Oncology Source Type: research

Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor α-mediated NF-κB Signaling Pathway in Macrophages
In conclusion, icariin attenuates wear particle-induced inflammation and osteolysis via down-regulation of the ERα-mediated NF-κB signaling pathway in macrophages. The potential application of icariin as a non-hormonal therapy for wear particle-induced periprosthetic osteolysis is worthy of further investigation.
Source: Frontiers in Pharmacology - November 3, 2021 Category: Drugs & Pharmacology Source Type: research

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin. Introduction Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Cancer stem cells (CSCs) in cancer progression and therapy
Most of the tumors are occupied with a number of self ‐renewing cells called cancer stem cells (CSCs) that are contributed to the initiation, maintenance, and thriving cancer. The cells have rather similar characteristics to other stem cells located in the niche of body organs, but they have not essentially the same responses to the diverse stimuli. There is evidence for repopulation of CSCs after treatment with chemo/radiotherapy, which is possibly because of their highly plastic feature. Normal stem cells have the proclivity to transform into CSCs when they undergo continuous mutagenesis or receive tumorigenic signals ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Masoud Najafi, Bagher Farhood, Keywan Mortezaee Tags: REVIEW ARTICLE Source Type: research

Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP-pathway.
Authors: Li M, Zhang C, Li X, Lv Z, Chen Y, Zhao J Abstract Isoquercitrin is widely present in fruits, vegetables and medicinal herbs. As a natural phytoestrogen, isoquercitrin has been considered a possible osteoporosis prevention option to avoid the risk of hormone therapy. In this work, we studied the effects of isoquercitrin on the cell proliferation and osteogenic differentiation of osteoblasts and bone mesenchymal stem cells (BMSCs), as well as the molecular mechanism of isoquercitrin action. The cell proliferation of osteoblasts and BMSCs was promoted by isoquercitrin at low concentrations. High concentratio...
Source: Connective Tissue Research - June 4, 2018 Category: Research Tags: Connect Tissue Res Source Type: research

Estrogen receptor {beta}-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor {alpha} (TNF{alpha})-induced apoptosis Molecular Bases of Disease
Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the underlying molecular mechanisms remain poorly understood. The inflammatory cytokine TNFα causes EC apoptosis while dysregulating the Notch pathway, a major contributor to EC survival. We have previously reported that 17β-estradiol (E2) treatment activates Notch signaling in ECs. Here, we sought to assess whether in TNFα-induced inflammation Notch is involved in E2-mediated protection...
Source: Journal of Biological Chemistry - November 3, 2017 Category: Chemistry Authors: Francesca Fortini, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Giorgio Aquila, Micaela Pannella, Antonio Pannuti, Lucio Miele, Roberto Ferrari, Paola Rizzo Tags: Cell Biology Source Type: research

Estrogen suppresses breast cancer proliferation through GPER / p38 MAPK axis during hypoxia
In conclusion, Estrogen suppresses breast cancer growth by inhibiting G1/S phase transition through GPER/ROS/p38 MAPK/p21 mediated signaling during hypoxic condition.
Source: Molecular and Cellular Endocrinology - November 6, 2015 Category: Endocrinology Source Type: research

Abstract 2312: Identifying novel cancer stem cell target for triple-negative breast cancer
The objective of this study was to investigate the role of HN1L in regulating BCSC and metastasis in TNBC, and to determine the mechanism of action of HN1L in BCSC. Knocking down HN1L by shRNA in SUM159 and MDAMB231 cell lines significantly decreased mammosphere forming efficiency (MSFE) and CD44+/CD24low/- population. To assess the contribution of HN1L to BCSC and tumor growth, a patient derived human-cancer-in-mouse xenograft model and two cancer cell line xenograft models were employed. To ensure targeted delivery, siRNA was packaged into DOPC liposomes and delivered into mice via intraperitoneal injection. Results show...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Liu, Y., Choi, D. S., Grandos-Principal, S., Qian, W., Burey, L., Wong, H., Rodriguez-Aguayo, C., Sood, A., Li, Z., Wong, S., Weiss, H., Dave, B., Landis, M., Chang, J. C. Tags: Tumor Biology Source Type: research