Filtered By:
Specialty: Genetics & Stem Cells
This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 1523 results found since Jan 2013.
GSE203325 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis miRNA-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A inte...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE203263 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis BiSulfite-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A interac...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE185699 NAP1L5 is required for translation activation during cardiomyocyte hypertrophy
Contributors : Ningning Guo ; Di Zheng ; Jiaxin Sun ; Jian Lv ; Shun Wang ; Yu Fang ; Zhenyi Zhao ; Sai Zeng ; Qiuxiao Guo ; Jingjing Tong ; Zhihua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPathological growth of cardiomyocytes during hypertrophy is characterized by excess protein synthesis; however, the regulatory mechanism remains largely unknown. Using a neonatal rat ventricular myocyte (NRVMs) model, here we find that the expression of nucleosome assembly protein 1 like 5 (Nap1l5) is upregulated in phenylephrine (PE)-induced hypertrophy. Knockdown of Nap1l5 expressi...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE214842 ATF6 αis required for the inflammation and survival in rheumatoid arthritis fibroblast-like synoviocytes
Contributors : L Ge ; L Wang ; Y ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize transcriptome changes upon ATF6 α knockdown by the siRNA in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs)
Source: GEO: Gene Expression Omnibus - October 6, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE214453 Alphavirus infection triggers antiviral RNAi immunity in mammals
Contributors : Jing Kong ; Yuanyuan Bie ; Wenting Ji ; Jiuyue Xu ; Bao Lyu ; Xiaobei Xiong ; Yang Qiu ; Xi ZhouSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Aedes aegypti ; Homo sapiens ; Mus musculusRNA interference (RNAi) functions as an antiviral immune response in plants and invertebrates, whereas mammalian RNAi response has been found so far only in undifferentiated cells and in differentiated cells inactive in interferon (IFN) system or in infections with viruses disabling viral suppressors of RNAi (VSRs), thereby leading to questio...
Source: GEO: Gene Expression Omnibus - October 4, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Aedes aegypti Homo sapiens Mus musculus Source Type: research
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization
Gene. 2022 Sep 30:146928. doi: 10.1016/j.gene.2022.146928. Online ahead of print.ABSTRACTBone formation is controlled by histone modifying enzymes that regulate post-translational modifications on nucleosomal histone proteins and control accessibility of transcription factors to gene promoters required for osteogenesis. Enhancer of Zeste homolog 2 (EZH2/Ezh2), a histone H3 lysine 27 (H3K27) methyl transferase, is a suppressor of osteoblast differentiation. Ezh2 is regulated by SET and MYND domain-containing protein 2 (SMYD2/Smyd2), a lysine methyltransferase that modifies both histone and non-histone proteins. Here, we exa...
Source: Gene - October 3, 2022 Category: Genetics & Stem Cells Authors: Parisa Dashti Jeroen van de Peppel Roman Thaler Christopher R Paradise Gary S Stein Martin A Montecino Johannes P T M van Leeuwen Bram J van der Eerden Amel Dudakovic Andre J van Wijnen Source Type: research
GSE186225 CUT-tag analysis of T24 cells treated with a control scramble (scr) siRNA or a si-circSLC38A1
This study aims to investigate whether circSLC38A1 could affect the enrichment of downstream genes by the transcription factor ILF3.T24 cells were treated with a control scramble (scr) siRNA or a siRNA that specifically knock down the expression of circSLC38A1, 48h after ttansfection, cells were collected and treated for CUT-tag.CUT-tag-Seq analysis provided evidence of ILF3 enrichment of downstream genes changes between si-NC and si-circSLC38A1 T24 cells.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE185523 RNASeq of human bronchial epithelial (HBE) cells with cGAS-siRNA transfected
Contributors : Zhangchu Jin ; Wenqi Diao ; Anyi Guo ; Shiyi Yang ; Yinling Han ; Yinfang Wu ; Yun Zhao ; Yanping Wu ; Jiaxin Shen ; Songmin Ying ; Wen Li ; Huhao Shen ; Zhihua Chen ; Fugui YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a newly discovered sensor that detects cytosolic DNA as a universal danger-associated molecular pattern (DAMP). Here, we used RNA-seq to analyze transcriptomic expression difference between control-siRNA and cGAS-siRNA cells to find out what genes involved in the r...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE135920 Reprogramming of root cells during nitrogen-fixing symbiosis entails dynamic polysome association of coding and non-coding RNAs
Contributors : Soledad Traubenik ; Mauricio Reynoso ; Karen Hobecker ; Marcos Lancia ; Maureen Hummel ; Benjamine Rosen ; Christhpher Town ; Julia Bailey-Serres ; Flavio A Blanco ; Maria E ZanettiSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago truncatulaGMUCT 2.0 data were analyzed to globally identify 5 ’ ends differentially accumulated in SKI3 RNAi roots as compared with GUS RNAi, as well as those that change in abundance in response to rhizobiaSUPERKILLER3 (*SKI3),* a member of SKI complex that guides RNAs to the 3 to 5' exoribonuclease of the exosome complex. In the absence of a fu...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Medicago truncatula Source Type: research
GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE206084 RNA-seq on primary human kidney epithelial cells with oleate treatment and PLIN2 knockdown
Contributors : Haikuo Li ; Benjamin D HumphreysSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated the transcriptomic changes induced by oleic acid treatment on human Primary Renal Proximal Tubule Epithelial Cells (RPTECs) with RNA-seq. We also profiled cells with oleic acid treatment after PLIN2 gene knockdown with siRNA treatment.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE169129 VPRBP, a novel androgen receptor and OGT target is an essential mediator of cellular transformation in prostate cancer
In this study, we employed chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) to identify changes in p53 binding to the genome in VPRBP knockdown LNCaPs compared to scrambled siRNA transfected control cells. Stabilization of p53 was associated increased p53 recruitment to the chromatin.
Source: GEO: Gene Expression Omnibus - September 22, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations
Retinitis pigmentosa (RP) is the most common cause of hereditary blindness, and may occur in isolation as a non-syndromic condition or alongside other features in a syndromic presentation. Biallelic or monoallelic mutations in one of eight genes encoding pre-mRNA splicing factors are associated with non-syndromic RP. The molecular mechanism of disease remains incompletely understood, limiting opportunities for targeted treatment. Here we use CRISPR and base edited PRPF6 and PRPF31 mutant cell lines, and publicly-available data from human PRPF31+/− patient derived retinal organoids and PRPF31 siRNA-treated organotypic ret...
Source: Frontiers in Genetics - September 13, 2022 Category: Genetics & Stem Cells Source Type: research
GSE212324 RNA-sequencing in for Low, high or high density+PTPRK-deleted HeLa cells
Contributors : Hyun A Sohn ; Young I Yeom ; Dong C LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDensity-dependent regulation of cell growth is presumed to be caused by cell-cell contact, but the underlying molecular mechanism is not yet clearly defined. Our goal is to identify receptor-type protein tyrosine phosphatase-kappa (PTPRK) is an important regulator of cell contact-dependent growth inhibition and to elucidate the related mechanism regulated by PTPRK with analyzing transcriptome-based datasets generated from different condition of cell density combined with manipulation ...
Source: GEO: Gene Expression Omnibus - September 2, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
