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Total 1545 results found since Jan 2013.

Effects of targeted silencing of FOXC1 gene on proliferation and in vitro migration of human non-small-cell lung carcinoma cells.
CONCLUSION: Silencing FOXC1 may evidently inhibit the migration of these cells by reversing the EMT process through suppressing cadherin, being associated with the expressions of extracellular MMPs. PMID: 27648121 [PubMed - as supplied by publisher]
Source: American Journal of Translational Research - September 22, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Effects of Aquaporin 4 Knockdown on Brain Edema of the Uninjured Side After Traumatic Brain Injury in Rats.
CONCLUSIONS AQP4 interference reduces CBT edema formation, and ADC value may predict TBI severity. PMID: 27930615 [PubMed - in process]
Source: Medical Science Monitor - December 9, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Extracellular matrix metalloproteinase inducer enhances host resistance against pseudomonas aeruginosa infection through MAPK signaling pathway.
In conclusion, EMMPRIN promotes host resistance against pseudomonas aeruginosa infection via MAPK signaling pathway. PMID: 28078032 [PubMed]
Source: American Journal of Translational Research - January 13, 2017 Category: Research Tags: Am J Transl Res Source Type: research

YM155 Down-Regulates Survivin and Induces P53 Up-Regulated Modulator of Apoptosis (PUMA)-Dependent in Oral Squamous Cell Carcinoma Cells.
CONCLUSIONS YM155 is a potent inhibitor of progression of SCC9 cells, which could be due to attenuation of survivin, and activation of the PUMA/caspase-3 cellular signaling processes. This study suggests that YM155 may be a potential molecular target with therapeutic relevance for the treatment of OSCC. PMID: 28435150 [PubMed - in process]
Source: Medical Science Monitor - April 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).
CONCLUSIONS LTC suppressed osteosarcoma proliferation, migration, and invasion by inhibiting IGF-1R expression. IGF-1R is one of the targets in LTC suppressing osteosarcoma. PMID: 28844074 [PubMed - in process]
Source: Medical Science Monitor - August 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF- κB and MAPK pathways.
P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF-κB and MAPK pathways. Am J Transl Res. 2017;9(11):4954-4962 Authors: Wu Q, Xu H, Hao L, Ma G, Sun J, Song X, Ding F, Wang N Abstract Previous studies have provided evidence for the regulatory effect of P2X7 receptor (P2X7R) on cardiovascular activities. Our study focused on exploring the function and fundamental mechanism of microglial P2X7R in controlling sympathoexcitatory response using rats with acute myocardial infarction (AMI). Coronary artery ligation was used in rats to cause AMI. And before that, rats wer...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research

The Sineoculis Homeobox Homolog 1 (SIX1) Gene Regulates Paclitaxel Resistance by Affecting Reactive Oxygen Species and Autophagy in Human Hepatocellular Carcinoma Cell Line HepG2.
CONCLUSIONS Knockdown of SIX1 increased cell ROS levels and autophagy, promoted cell apoptosis, and enhanced TAX sensitivity of HepG2 cells. PMID: 29656300 [PubMed - in process]
Source: Medical Science Monitor - April 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of the Long Intergenic Non-Coding RNA (lincRNA) of the NED25 Gene Modulates the microRNA-125b, STAT3, Nitric Oxide, and Procalcitonin Signaling Pathways in Patients with Sepsis.
CONCLUSIONS Downregulation of the lincRNA of the NED25 gene was associated with sepsis in patients by modulating the signaling pathways downstream of miR-125b/STAT3/PCT/NO signaling pathway. PMID: 29962507 [PubMed - in process]
Source: Medical Science Monitor - July 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.
CONCLUSIONS miR-146b could regulate the expression of circRNAs in HSCs, which might take part in the formation and development of hepatic fibrosis. PMID: 30504757 [PubMed - in process]
Source: Medical Science Monitor - December 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

To Explore the Protective Mechanism of PTEN-Induced Kinase 1 (PINK1)/Parkin Mitophagy-Mediated Extract of Periplaneta Americana on Lipopolysaccharide-Induced Cardiomyocyte Injury.
CONCLUSIONS The study provided evidence that XML regulated the process of LPS-induced cardiomyocyte injury through mitophagy by the PINK1/Parkin pathway. PMID: 30789157 [PubMed - in process]
Source: Medical Science Monitor - February 23, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of the therapeutic potential effect of Fas receptor gene Knockdown in experimental model of Non-Alcoholic Steatohepatitis.
CONCLUSIONS: The suppression of Fas receptor signaling subsequent RNAi therapy may represent an applicable strategy to decline hepatocyte damages and so NASH progression in mice. PMID: 31010354 [PubMed - as supplied by publisher]
Source: Free Radical Research - April 25, 2019 Category: Research Tags: Free Radic Res Source Type: research

Applications of RNA interference in the treatment of arthritis
RNA interference (RNAi) is a cellular mechanism for post-transcriptional gene regulation mediated by small interfering RNA (siRNA) and microRNA. siRNA-based therapy holds significant promise for the treatment of a wide-range of arthritic diseases. siRNA selectively suppresses the expression of a gene product and can thus achieve the specificity that is lacking in small molecule inhibitors. The potential use of siRNA-based therapy in arthritis, however, has not progressed to clinical trials despite ample evidence for efficacy in pre-clinical studies.
Source: Translational Research - July 9, 2019 Category: Research Authors: Muhammad Farooq Rai, Hua Pan, Huimin Yan, Linda J. Sandell, Christine T.N. Pham, Samuel A. Wickline Tags: Review Article Source Type: research

The role of KDR in intrauterine adhesions may involve the TGF- β1/Smads signaling pathway.
The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway. Braz J Med Biol Res. 2019;52(10):e8324 Authors: Chen JX, Yi XJ, Gu PL, Gao SX Abstract The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium verified with an uteroscope. In addition, 50 rats were randomly assigned into Control, Sham, Model, NC-siRNA, and KDR-siRNA group...
Source: Braz J Med Biol Res - October 11, 2019 Category: Research Authors: Chen JX, Yi XJ, Gu PL, Gao SX Tags: Braz J Med Biol Res Source Type: research

Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2.
Abstract Cisplatin- (CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin. Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin-induced AKI remain unknown. In the present study, we characterized the role and mechanism of Sirt5 in cisplatin-induced apoptosis using the human kidney 2 (HK-2) cell line. CDDP treatment decreased Sirt5 expression of HK-2 cells in a dose-dependent manner. In addition, Sirt5 overexpression enhanced the metabolic activity in CDDP-treated HK-2 cells while Sirt5 siRNA attenuated it. Forced expression of Sirt5 inhibited CDDP...
Source: Biomed Res - December 11, 2019 Category: Research Authors: Li W, Yang Y, Li Y, Zhao Y, Jiang H Tags: Biomed Res Int Source Type: research

Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/ β-catenin signaling.
Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/β-catenin signaling. Am J Transl Res. 2020;12(10):6853-6867 Authors: Dong S, Li J, Zhang X Abstract Human adipose derived stem/stromal cells (hASCs) are frequently used as seed cells in bone tissue engineering. These cells have good osteogenic properties in various in vivo and in vitro models. Tumor protein p53-induced nuclear protein 2 (TP53INP2) regulates apoptosis, autophagy, and cell differentiation. However, whether TP53INP2 regulates osteogenic differenti...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research