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Total 1545 results found since Jan 2013.

Activation of Sonic Hedgehog Signaling Is Associated with Human Osteosarcoma Cells Radioresistance Characterized by Increased Proliferation, Migration, and Invasion.
CONCLUSIONS Activation of Shh signaling was involved in radioresistance of OS cells. Blocking this signaling can impair the radioresistance capacity of OS cells. PMID: 29864766 [PubMed - in process]
Source: Medical Science Monitor - June 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

p38 MAPK is Crucial for Wnt1- and LiCl-Induced Epithelial Mesenchymal Transition
SummaryIdiopathic pulmonary fibrosis (IPF) is characterized by myofibroblast foci in lung parenchyma. Myofibroblasts are thought to originate from epithelial-to-mesenchymal transition (EMT). Wnt1 and lithium chloride (LiCl) induce EMT in alveolar epithelial cells (AECs), but the mechanisms are unclear. AECs were treated with Wnt1 and LiCl, respectively; morphological change and molecular changes of EMT, including E-cadherin, fibronectin, and vimentin, were observed. SB203580 was administrated to test the role of p38 МАРК signaling in EMT. Then AECs were treated with siRNAs targeting p38 МАРК to further test the eff...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 1, 2018 Category: Research Source Type: research

Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor- κB (TLR4/NF-κB) Signaling Pathway.
CONCLUSIONS LPA can promote MMP9 expression and enhance MMP9 activity in THP-1 cells, in part via the TLR4/NF-kB signaling pathway. PMID: 30005060 [PubMed - in process]
Source: Medical Science Monitor - July 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of the KINDLIN-2 Gene and Reduced Expression of Kindlin-2 Affects Vascular Permeability in Angiogenesis in a Mouse Model of Wound Healing.
CONCLUSIONS In a mouse model of wound healing, KINDLIN-2 gene knockdown inhibited wound healing, and increased neovascular permeability in vivo. PMID: 30070977 [PubMed - in process]
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Transforming Growth Factor β1 (TGF-β1) Appears to Promote Coronary Artery Disease by Upregulating Sphingosine Kinase 1 (SPHK1) and Further Upregulating Its Downstream TIMP-1.
CONCLUSIONS TGF-β1 appears to promote CAD through the induction of cell apoptosis by upregulating SPHK1 expression and further upregulating its downstream TIMP-1. PMID: 30317247 [PubMed - in process]
Source: Medical Science Monitor - October 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor- β3 Signaling Pathway.
Conclusions: YOD1 RNAi may inhibit cell proliferation and migration associated with the pathogenesis of NSCL/P through TGF-β3 signaling. The study indicates a novel role of YOD1 in regulating TGF-β3 signaling to affect cell proliferation and migration resulting in NSCL/P. PMID: 30345304 [PubMed - in process]
Source: Biomed Res - October 24, 2018 Category: Research Authors: Zhou XL, Chen G, Li MX, Wang HX, Hong JW, Shen JY, Wang Q, Ge X, Ding Z, Xu LC Tags: Biomed Res Int Source Type: research

Expression of the CD59 Glycoprotein Precursor is Upregulated in an Estrogen Receptor-alpha (ER- α)-Negative and a Tamoxifen-Resistant Breast Cancer Cell Line In Vitro.
CONCLUSIONS In summary, our results proposed a candidate biomarker for predicting TAM resistance in ERa-positive breast cancer via targeting CD59, therefore it could be a novel therapeutic option. PMID: 30391994 [PubMed - in process]
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinicopathological and prognostic significance of nuclear UGDH localization in lung adenocarcinoma.
This study aimed to clarify relationships among UDP-glucose-6 dehydrogenase (UGDH) expression, clinicopathological factors, and the prognosis of patients, and to determine the role of UGDH in lung adenocarcinoma (AC). Firstly, UGDH expression and localization in 126 lung AC tissues were immunohistochemically studied, and associations with clinicopathological parameters and patients' prognosis were evaluated. Secondly, serum UGDH levels were measured in 267 lung cancer patients and 100 healthy controls. Finally, the effects of UGDH knockdown by siRNA on migration and invasion abilities were analyzed. As a result, nuclear UG...
Source: Biomed Res - February 23, 2019 Category: Research Authors: Hagiuda D, Nagashio R, Ichinoe M, Tsuchiya B, Igawa S, Naoki K, Satoh Y, Murakumo Y, Saegusa M, Sato Y Tags: Biomed Res Source Type: research

Silencing of GPR82 with Interference RNA Improved Metabolic Profiles in Rats with High Fructose Intake
Metabolic syndrome (MS) is a clinical condition, constituted by alterations that lead to the onset of type II diabetes and cardiovascular disease. It has been reported that orphan G-protein-coupled receptor 82 (GPR82) participates in metabolic processes. The aim of this study was to evaluate the  function of GPR82 in MS using a small interfering RNA (siRNA) against this receptor. We used Wistar rats of 10–12 weeks of age fed with a high-fructose solution (70%) for 9 weeks to induce MS. Subsequently, the rats were treated with an intrajugular dose of an siRNA against GPR82 and the effects were evaluated on day 3 and 7 af...
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research

Knockdown of sphingomyelin synthase 2 inhibits osteoclastogenesis by decreasing RANKL expression in mouse primary osteoblasts.
Abstract Sphingomyelin is a major lipid of the plasma membrane and is enriched in microdomains of the plasma membrane that are critical for signal transduction. However, the function of sphingomyelin in the cell membrane of osteoblasts has not been clarified. Therefore, we examined how sphingomyelin synthase 2 (SMS2) affects osteoclast differentiation by osteoblasts. We knocked down the expression of SMS2 with siRNA targeting the Sgms2 gene in mouse primary osteoblasts. The effects of SMS2 knockdown in osteoblasts were examined using polymerase chain reaction and western blotting. The knockdown of SMS2 suppressed ...
Source: Biomed Res - October 12, 2019 Category: Research Authors: Yoshikawa Y, Yoshizawa T, Domae E, Hirai Y, Kamada A, Okazaki T, Ikeo T Tags: Biomed Res Source Type: research

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
CONCLUSIONS Orai1 activates the Ras-Rac1-WAVE2 signaling pathway to promote metastasis of osteosarcoma. Abnormal expression or function of Orai1 may be an important cause of osteosarcoma metastasis. PMID: 31796725 [PubMed - in process]
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Exosome-based targeted RNA delivery for immune tolerance induction in skin transplantation.
In conclusion, we constructed a new exosome-based targeted delivery system which could effectively induce the immune tolerance in transplantation. This article is protected by copyright. All rights reserved. PMID: 32170897 [PubMed - as supplied by publisher]
Source: Biomed Res - March 13, 2020 Category: Research Authors: Li C, Guo F, Wang X, Liu D, Wu B, Wang F, Chen W Tags: J Biomed Mater Res A Source Type: research

Effects of the multifunctional hormone leptin on orthodontic tooth movement in rats.
This study aims to investigate the effects of leptin, which is a multifunctional hormone, on orthodontic tooth movement (OTM) and the underlying mechanism. Sprague-Dawley rat OTM models were established and divided into two groups with the administration of vehicle or leptin respectively. Stereomicroscope and microcomputed tomography were used to evaluate the amount of OTM. TRAP staining, immunohistochemical and immunofluorescence staining were used to detect osteoclasts and relative protein expressions. After treated with compression force, human periodontal ligament cells (hPDLCs) were co-cultured with human peripheral b...
Source: American Journal of Translational Research - June 10, 2020 Category: Research Tags: Am J Transl Res Source Type: research

FBN1 promotes DLBCL cell migration by activating the Wnt/ β-catenin signaling pathway and regulating TIMP1.
FBN1 promotes DLBCL cell migration by activating the Wnt/β-catenin signaling pathway and regulating TIMP1. Am J Transl Res. 2020;12(11):7340-7353 Authors: Wang H, Liu Z, Zhang G Abstract The heterogeneity of diffuse large B-cell lymphoma (DLBCL) acts as a main barrier to identify the genetic basis of the disease and the choice of treatment. Differentially expressed genes (DEGs) from three mRNA expression profile datasets were screened using GEO2R, and bioinformatics analysis was performed on the DEGs. A total of six upregulated and 13 downregulated DEGs were identified. Among these, two hub genes with...
Source: American Journal of Translational Research - December 15, 2020 Category: Research Tags: Am J Transl Res Source Type: research

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes
Conclusion: RIG-I and MDA5 may play a role in the antiviral responses of podocytes.
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKATA, M., SHIMADA, M., NARITA-KINJO, I., NAGAWA, D., KITAYAMA, K., HAMADATE, M., MIURA, N., NOZAKA, M., KAWAMURA, Y., FUJITA, T., MURAKAMI, R., IMAIZUMI, T., NAKAMURA, N., TOMITA, H. Tags: Experimental Studies Source Type: research