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Aberrant SERPINE1 DNA methylation is involved in carboplatin induced epithelial-mesenchymal transition in epithelial ovarian cancer
ConclusionOur study suggested that SERPINE1 may be a promising therapeutic target for chemoresistance.
Source: Archives of Gynecology and Obstetrics - October 3, 2017 Category: OBGYN Source Type: research

Akt-mTOR Signaling Mediates Abnormalities in the Proliferation and Apoptosis of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome
This study showed that 1 nM of insulin significantly stimulated cell proliferation, induced cell apoptosis, and decreased the telomerase activity in GCs from both the healthy women and PCOS patients (p
Source: Gynecologic and Obstetric Investigation - July 21, 2017 Category: OBGYN Source Type: research

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.
Authors: Cai M, Kolluru GK, Ahmed A Abstract MicroRNAs are small, noncoding RNA molecules that regulate target gene expression in the posttranscriptional level. Unlike siRNA, microRNAs are "fine-tuners" rather than "switches" in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis. The aberrant microRNA expression is implicated in the disease process. To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE)...
Source: Journal of Pregnancy - July 19, 2017 Category: OBGYN Tags: J Pregnancy Source Type: research

WTIP interacts with BRCA2 and is essential for BRCA2 centrosome localization in cervical cancer cell
ConclusionThis study indicates that WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell.
Source: Archives of Gynecology and Obstetrics - October 19, 2016 Category: OBGYN Source Type: research

Cyclin-Dependent Kinase 14 Promotes Cell Proliferation, Migration and Invasion in Ovarian Cancer by Inhibiting Wnt Signaling Pathway
Objective: The study aimed to investigate cyclin-dependent kinase 14 (CDK14) and its co-function with Wnt signaling pathway on cell proliferation, migration and invasion in ovarian cancer.Methods: CDK14 expressions were detected by quantitative real-time polymerase chain reaction. The expressions c-Myc, cyclinD1, PFTK1, ki67 and OGT were examined by Western blot. MTT assay was applied to observe cell proliferation after transfection of pEGFP-N1/CDK14-siRNA and pEGFP-N1 into SKOV3 cells, and scratch test and Transwell assay to observe invasion and migration ability. Transfected tumor model in nude mice was established.Resul...
Source: Gynecologic and Obstetric Investigation - August 9, 2016 Category: OBGYN Source Type: research

Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells.
CONCLUSION: Apelin can promote proliferation of GCs and inhibit apoptosis via PI3/Akt signaling pathway. PMID: 27328502 [PubMed - in process]
Source: Clinical and Experimental Obstetrics and Gynecology - June 23, 2016 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research

Effects of silencing MTA1 gene by RNA interference on invasion and metastasis of endometrial carcinoma.
CONCLUSION: RNAi aiming at MTA1 can effectively inhibit the expression of MTA1 in endometrial carcinoma Ishikawa cells and the effective silence of MTA1 can weaken the invasion and metastasis of Ishikawa cells, which provides a new strategy for gene therapy of endometrial carcinoma and an experimental basis for inhibiting the invasion and metastasis of endometrial carcinoma. PMID: 27048111 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - April 7, 2016 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta
Conclusion This study confirms that the PI3K/Akt cell protection pathway is down regulated in preeclampsia, but demonstrates that this dysregulation is unlikely to be responsible for the excessive placental soluble endoglin release characteristic of preeclampsia.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 28, 2016 Category: OBGYN Source Type: research

Cytoplasmic p21 is responsible for paclitaxel resistance in ovarian cancer A2780 cells.
CONCLUSION: Cytoplasmic p21 may represent a potential therapeutic target for ovarian tumors that are resistant to PTX treatment. PMID: 26775347 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - January 21, 2016 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

miR-31 functions as an oncogene in cervical cancer
Conclusions Our results suggested that miR-31 plays an oncogenetic role in the development and progression of cervical cancer.
Source: Archives of Gynecology and Obstetrics - September 29, 2015 Category: OBGYN Source Type: research

AK000953 silencing can enhance the killing effect of danazol on uterine fibroids
Conclusion AK000953 silencing could effectively enhance the killing effect of danazol on uterine fibroid cells.
Source: Archives of Gynecology and Obstetrics - September 29, 2015 Category: OBGYN Source Type: research

O13. Catechol-O-methyltransferase deficiency leads to hypersensitivity on the pressor response against angiotensin II
Conclusion Deficiency in COMT and 2-ME are associated with the hypersensitivity on the pressor response against AngII infusion. Similar mechanisms could be relevant to pregnant status and PE.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

38-OR Sexual dimorphism in the effect of inflammation on trophoblast function with preeclampsia
Conclusions We find sexual dimorphism in the effect of inflammation on placental miR-210 expression perhaps mediated by the NFκB1 pathway. This may link placental inflammation in preeclampsia to decreased mitochondrial function in pregnancies with a female fetus. Disclosures L. Myatt: None. C. Guo: None. S. Muralimanoharan: None. A. Maloyan: None.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 24, 2015 Category: OBGYN Source Type: research

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin
Conclusion In conclusion, we present a protocol that yields primary trophoblasts of high purity that produce abundant sFlt-1 and low but detectable levels of sEng. Furthermore, these cells are readily amenable to gene silencing by siRNAs and hence suitable for functional studies.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 17, 2015 Category: OBGYN Source Type: research

Silencing sexually transmitted infections: topical siRNA-based interventions for the prevention of HIV and HSV.
Authors: Wheeler LA Abstract The global impact of sexually transmitted infections (STIs) is significant. The sexual transmission of viruses such as herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1 (HIV-1), has been especially difficult to control. To date, no effective vaccines have been developed to prevent the transmission of these STIs. Although antiretroviral drugs have been remarkably successful in treating the symptoms associated with these viral infections, the feasibility of their widespread use for prevention purposes may be more limited. Microbicides might provide an attract...
Source: Infectious Diseases in Obstetrics and Gynecology - November 18, 2014 Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research

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