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Specialty: OBGYN
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Total 49 results found since Jan 2013.
Low-dose mifepristone increased angiogenesis in a manner involving AQP1
ConclusionsLow-dose mifepristone increased angiogenesis in a manner involving AQP1. This affords a new insight into the molecular mechanism underpinning the angiogenic effects of low-dose mifepristone.
Source: Archives of Gynecology and Obstetrics - December 19, 2018 Category: OBGYN Source Type: research
Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway
Conclusion: Inhibition of ZEB1-AS1 can block the p38MAPK signaling pathway, ultimately restricting the EMT and suppressing cell migration and invasion of cervical cancer cells.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - October 5, 2018 Category: OBGYN Source Type: research
Early missed abortion is associated with villous angiogenesis via the HIF-1 α/VEGF signaling pathway
ConclusionsOur results reveal a novel role for HIF-1 α/VEGF in regulating villous angiogenesis in early pregnancy and suggest that it may be a novel biomarker for missed abortion.
Source: Archives of Gynecology and Obstetrics - August 10, 2018 Category: OBGYN Source Type: research
Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. BrenneckeAbstractDecidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research
Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018Source: Pregnancy HypertensionAuthor(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian LiAbstractPreeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially me...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research
Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1
ConclusionsWe proved that PGK1 and PGK1P2 are a pair of ceRNAs against miR-330-5p and they play a vital role in human decidualization by regulating angiogenesis and glycolysis metabolism. The deficiency of PGK1 and PGK1P2 in the decidua jeopardizes the decidualization process and subsequently might lead to the occurrence of PE. These findings may help in promoting novel predictive, diagnostic and prognostic biomarkers of PE in future.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research
Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. BrenneckeAbstractDecidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 5, 2018 Category: OBGYN Source Type: research
Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018Source: Pregnancy HypertensionAuthor(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian LiAbstractPreeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially me...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 5, 2018 Category: OBGYN Source Type: research
Construction and identification of a model for HJURP gene defect expression in human embryo villus cells.
CONCLUSION: A lentiviral shRNA expression vector targeting the HJURP gene was successfully constructed and may effectively silence the target gene at a cellular level, which provides a experimental model for the influence of HJURP gene expressing inhibition on human embryo villus cells multiplication and chromosome segregation.
PMID: 29949288 [PubMed - in process]
Source: Clinical and Experimental Obstetrics and Gynecology - June 30, 2018 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Effect of Wnt/ β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis.
CONCLUSION: Blocking of Wnt/β-catenin signal pathway caused the decrease of MMP-7 and VEGF expressions, in- dicating that Wnt/β-catenin signal pathway plays an important role in the adhesion, invasion, and metastasis of endometriosis tissues.
PMID: 29734552 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - May 10, 2018 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1
Conclusions We proved that PGK1 and PGK1P2 are a pair of ceRNAs against miR-330-5p and they play a vital role in human decidualization by regulating angiogenesis and glycolysis metabolism. The deficiency of PGK1 and PGK1P2 in the decidua jeopardizes the decidualization process and subsequently might lead to the occurrence of PE. These findings may help in promoting novel predictive, diagnostic and prognostic biomarkers of PE in future.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 4, 2018 Category: OBGYN Source Type: research
Non-coding RNAs in endometriosis: a narrative review
AbstractBACKGROUNDEndometriosis is a benign gynaecological disorder, which affects 10% of reproductive-aged women and is characterized by endometrial cells from the lining of the uterus being found outside the uterine cavity. However, the pathophysiological mechanisms causing the development of this heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. There is international recognition that accurate non-invasive diagnostic tests and more effective therapies are urgently needed. Non-coding RNA (ncRNA) molecules, which are important regulators of cellula...
Source: Human Reproduction Update - April 25, 2018 Category: OBGYN Source Type: research
Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018 Source:Pregnancy Hypertension Author(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian Li Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially methyla...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 24, 2018 Category: OBGYN Source Type: research
Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: Available online 14 November 2017 Source:Pregnancy Hypertension Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. Brennecke Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration an...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 16, 2017 Category: OBGYN Source Type: research
