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Total 49 results found since Jan 2013.

Silencing sexually transmitted infections: topical siRNA-based interventions for the prevention of HIV and HSV.
Authors: Wheeler LA Abstract The global impact of sexually transmitted infections (STIs) is significant. The sexual transmission of viruses such as herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1 (HIV-1), has been especially difficult to control. To date, no effective vaccines have been developed to prevent the transmission of these STIs. Although antiretroviral drugs have been remarkably successful in treating the symptoms associated with these viral infections, the feasibility of their widespread use for prevention purposes may be more limited. Microbicides might provide an attract...
Source: Infectious Diseases in Obstetrics and Gynecology - November 18, 2014 Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research

Effects of silencing MTA1 gene by RNA interference on invasion and metastasis of endometrial carcinoma.
CONCLUSION: RNAi aiming at MTA1 can effectively inhibit the expression of MTA1 in endometrial carcinoma Ishikawa cells and the effective silence of MTA1 can weaken the invasion and metastasis of Ishikawa cells, which provides a new strategy for gene therapy of endometrial carcinoma and an experimental basis for inhibiting the invasion and metastasis of endometrial carcinoma. PMID: 27048111 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - April 7, 2016 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

AK000953 silencing can enhance the killing effect of danazol on uterine fibroids
Conclusion AK000953 silencing could effectively enhance the killing effect of danazol on uterine fibroid cells.
Source: Archives of Gynecology and Obstetrics - September 29, 2015 Category: OBGYN Source Type: research

Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway
Conclusion: Inhibition of ZEB1-AS1 can block the p38MAPK signaling pathway, ultimately restricting the EMT and suppressing cell migration and invasion of cervical cancer cells.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - October 5, 2018 Category: OBGYN Source Type: research

Effect of IL-15-Mediating IFN- γ on HTR-8/SVneo Cells and a Preeclampsia Mouse Model Induced by Lipopolysaccharides
Conclusion: IL-15 inhibition reduced cell apoptosis and increased the invasive and migratory abilities of LPS-induced HTR-8/SVneo cells, thereby alleviating the PE-like phenotype and improving pregnancy outcome.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - June 9, 2021 Category: OBGYN Source Type: research

Enhancement of ovarian cancer chemotherapy by delivery of multidrug‐resistance gene small interfering RNA using tumor targeting Salmonella
ConclusionAttenuated Salmonella typhi may represent a promising vector for in vivo administration of RNA interference therapy against malignant tumors.
Source: Journal of Obstetrics and Gynaecology Research - November 5, 2014 Category: OBGYN Authors: Jiaqi Deng, Yi Guo, Zhongmin Jiang, Min Yang, Huaifang Li, Jianjun Wang Tags: Original Article Source Type: research

Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells.
CONCLUSION: Apelin can promote proliferation of GCs and inhibit apoptosis via PI3/Akt signaling pathway. PMID: 27328502 [PubMed - in process]
Source: Clinical and Experimental Obstetrics and Gynecology - June 23, 2016 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research

Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells
Conclusions: This study has demonstrated the principle that the simultaneous suppression of c-Src and STAT3 inhibits the growth of epithelial ovarian cancer cells and seems to enhance the cytotoxicity of chemotherapeutic agents in ovarian cancer.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 14, 2013 Category: OBGYN Authors: Shin-Wha Lee, Jin Yoo, Soo-Hyoung Lee, Dongho Kim, Yong-Man Kim, Young-Tak Kim Tags: Gynecology and Gynecological Oncology Source Type: research

O13. Catechol-O-methyltransferase deficiency leads to hypersensitivity on the pressor response against angiotensin II
Conclusion Deficiency in COMT and 2-ME are associated with the hypersensitivity on the pressor response against AngII infusion. Similar mechanisms could be relevant to pregnant status and PE.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

Early missed abortion is associated with villous angiogenesis via the HIF-1 α/VEGF signaling pathway
ConclusionsOur results reveal a novel role for HIF-1 α/VEGF in regulating villous angiogenesis in early pregnancy and suggest that it may be a novel biomarker for missed abortion.
Source: Archives of Gynecology and Obstetrics - August 10, 2018 Category: OBGYN Source Type: research

The diagnostic value and regulatory mechanism of miR-200a targeting ZEB1 in pregnancy-induced hypertension.
Conclusion: MiR-200a was upregulated in PIH patients, andinhibition of miR-200a may improve disease progression, as it could facilitatetrophoblastproliferation, migration and invasionandinhibitapoptosisby targeting ZEB1. PMID: 32345067 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - May 1, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

miR-31 functions as an oncogene in cervical cancer
Conclusions Our results suggested that miR-31 plays an oncogenetic role in the development and progression of cervical cancer.
Source: Archives of Gynecology and Obstetrics - September 29, 2015 Category: OBGYN Source Type: research

Cytoplasmic p21 is responsible for paclitaxel resistance in ovarian cancer A2780 cells.
CONCLUSION: Cytoplasmic p21 may represent a potential therapeutic target for ovarian tumors that are resistant to PTX treatment. PMID: 26775347 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - January 21, 2016 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells
ConclusionsCollectively, the findings of this study indicated that FSH promoted glycolysis in epithelial ovarian cancer cells. Knockdown of PKM2 inhibited aerobic glycolysis and cell proliferation induced by FSH.
Source: Archives of Gynecology and Obstetrics - April 20, 2019 Category: OBGYN Source Type: research

Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells
ConclusionThis study is the first to reveal that ZEB1-AS1 plays a pivotal role in cancer chemoresistance.
Source: Archives of Gynecology and Obstetrics - April 18, 2021 Category: OBGYN Source Type: research