MiRNAs: regulators of human disease.
Authors: Kontomanolis EN, Koukouli A, Liberis G, Stanulov H, Achouhan A, Pagkalos A Abstract MicroRNAs (miRNAs) represent the mediators of important leading biological functions of molecular pathways in humans. They are a class of very small, non-coding RNAs; their function is the balance of the protein levels at the post-transcriptional stage. They are implicated in molecular processes and diseases, including diabetes, metabolism, autoimmune diseases, angiogenesis and tumorigenesis, and female fertility, exhibiting an altered expression profile. Any process taking place in the human organism is intertwined by miRN...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

A novel surgical technique for the large ovarian cystic mass - combined mini-laparotomy and laparoscopy.
CONCLUSION: Combined mini-laparotomy and laparoscopy to resect ovarian masses> ten cm has potential benefits for patients in terms of faster recovery, lower analgesia requirements, and improved cosmetic outcome. Larger prospective studies are required to adequately assess complication rates, quality of life, and long-term outcomes in those patients with ovarian tumours of low malignant potential. PMID: 29943917 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Does prophylactic bilateral salpingectomy during pelviscopic hysterectomy increase perioperative morbidity?.
CONCLUSION: Prophylactic salpingectomy performed during a laparoscopic hysterectomy for benign conditions seems to be' safe and recommended. Prospective studies especially with respect to the magnitude of the prophylactic effect are needed. PMID: 29943918 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Treatment and outcome of Stage I Al squamous carcinoma of the cervix: a clinicopathologic study of 346 cases.
CONCLUSIONS: the treatments for Stage I Al SCC are becoming more conservative, and individualized therapy and more frequent surveillance should be administrated to those patients with LVSI. PMID: 29943919 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The effects of intraperitoneal chemotherapeutic agents on adhesion formation.
CONCLUSION: It is suggested to use the drugs which have a proven anti-adhesion feature or barriers to the patients who are going to be applied intraperitoneal chemotherapy with paclitaxel. PMID: 29943920 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The impact of conisation on pregnancy outcome.
The objective of present study was to investigate whether conisation is associated with adverse pregnancy outcomes in Flanders, Belgium. Therefore a retrospective cohort study was conducted at the Antwerp University Hospital. MATERIALS AND METHODS: The study was approved by the Ethical Committee and based on a questionnaire as well as on medical records. Confounders, like smoking, alcohol use, drug use, chronic illness, and gynaecological disorders during pregnancy were all taken into account. A multiple logistic regression was performed for an association between adverse pregnancy outcomes and confounders. RESULTS...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Ovarian metastases from colorectal cancer: prognostic role of prophylactic oophorectomy. A single center experience.
Authors: Sianesi M, Bertocchi E, Rossini M, Del Rio P, Viani L Abstract BACKGROUND: The incidence of ovarian metastases (OM) from colorectal cancer (CRC) is uncommon but women with OM from CRC had poorer quality of life and decreased survival. Mateials and Methods: The authors retrospectively categorized women submitted to surgery for CRC from January 2004 to December 2012 considering previous mono- or bilateral-oophorectomy, oophorectomy performed during colorectal resection, and oophorectomy performed after surgery for CRC and its cause. The analysis focused on two groups: women who underwent surgery for CRC befo...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

A survey of knowledge and awareness of Jordanian female university students of human papillomavirus infection and its vaccine.
CONCLUSION: The study suggests that more health education and information about the HPV characteristics and HPV vaccine is needed for female university students. PMID: 29943923 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Docetaxel and nab-paclitaxel are safe alternative options for patients with gynecologic malignancies following hypersensitivity reaction to paclitaxel.
Authors: Brightwell R, Handel E, Eng K, Grzankowski K, Frederick P, Odunsi K, Lele S Abstract Docetaxel and nab-paclitaxel are safe alternatives to paclitaxel after hypersensitivity reaction occurs. There was no significant difference in overall survival between those that had paclitaxel, docetaxel, and nab-paclitaxel. PMID: 29943924 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Complications of laser conization versus loop electrosurgical excision procedure in pre- and postmenopausal patients.
This study recruited a total of 551 patients. In the laser group (n = 405), there were 361 (89.1%) premenopausal and 44 (10.9%) postmenopausal women. In the LEEP group (n = 146), there were 129 (88.4%) premenopausal and 17 (11.6%) postmenopausal women. The factors investigated in both groups were the length of the tissue cone removed and the presence of positive endocervical cone margins, residual disease, and cervical stenosis. RESULTS: In the laser group, the length of the tissue cone was significantly longer in postmenopausal patients (17.9 ±3.9 mm vs. 15.7 ± 3.6mm; p = 0.002). The rate of positive end...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Malignant transformation of mature cystic teratoma of the ovary: 30-year experience of a single tertiary care center.
CONCLUSION: Malignant transformation of MCT is large ovarian tumors that mainly occur in patients in their fifth and sixth decades of life. They often present as incidental pathologic findings after surgery for MCT. SCC has traditionally been the most common pathology, however in the present series, the authors found that papillary thyroid carcinoma was equally common. Platinum-based chemotherapy with pelvic radiation in early stage (including Stage IA) and locally recurrent dis- ease should be offered. Advanced stages and mucinous adenocarcinoma represent a poorer prognosis despite adjuvant treatment. In patients with pap...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Clinical and epidemiological profile of women with breast cancer managed in a public referral hospital in northeastern Brazil.
CONCLUSION: The current study shows that the majority of carcinomas were Stage II or advanced tumors, with clinically positive axillary lymph node status and weak correlation with reproductive risk factors. PMID: 29943927 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

A retrospective analysis of patients treated for gestational trophoblastic diseases: a 4-year experience of a tertiary hospital.
CONCLUSION: The GTD incidence in this clinic is high with a rate of 3.3/1,000 per pregnancy compared to Turkish literature. High birth rates of our population may play a role in high incidence results. Further investigation in this field is essential. PMID: 29943928 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Metastatic mammary carcinoma despite histologically negative sentinel lymph nodes: are there any indicators for estimating recurrence and metastasis rates?.
CONCLUSIONS: When assessing the risk profile for disease recurrence or the occurrence of metastatic disease, statistically significant differences with respect to disease progression were identified for the parameters chemo-, antibody, hormone, and radiation therapy. The preliminary observations of this study show that even those patients in an early disease stage and with negative SLNs profit from these adjuvant non-surgical therapy options. PMID: 29943929 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Endometrial malignancies arising on endometrial polyps and precursor lesions.
CONCLUSION: The authors found a precursor lesion in 20 (74%) of their patients who showed endometrial malignancy developing on endometrial polyps. Even when an overt malignancy is not detected on polyps in the curettage material, precursor lesions should be carefully searched. PMID: 29943930 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The effect of aprepitant and dexamethasone combination on paclitaxel-induced hypersensitivity reaction.
Authors: Yamamoto T, Natio M, Hara S, Kudo T, Miwa Y Abstract PURPOSE OF INVESTIGATION: Dexamethasone (DEX) is often administered to prevent paclitaxel (PTX)-induced hypersensitivity reactions (HSR). The DEX dose is reduced when administered in combination with aprepitant (APR). However, the influence of that dose reduction on PTX-induced HSR has not been thoroughly studied. The present authors aimed to investigate the effects of the combined administration of APR and DEX on PTX-induced HSR. MATERIALS AND METHODS: Fifty-one patients who received a three-week PTX regimen in combination with APR and DEX were retr...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Attitudes and knowledge among parents or guardians of 12-year-old girls about HPV vaccination - A population-based survey in Iceland.
CONCLUSION: In Iceland, willingness to vaccinate young girls with HPV vaccine is high, however, knowledge about HPV infections is limited. PMID: 29943932 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Diagnostic value of transvaginal color Doppler ultrasound on endometrial lesions.
CONCLUSIONS: Transvaginal color Doppler ultrasound has important diagnostic value in the case of endometrial lesions, has a high rate of detection and diagnostic on endometrial lesions, and is the best method for diagnosis of endometrial lesions. PMID: 29943933 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The ovarian cancers in geriatric population: the validity of inflammatory markers, malignancy risk indices 1, 2, 3, 4, and CA-125 levels in malignancy discrimination of adnexal masses.
CONCLUSION: RMI algorithms were the best models for malignancy prediction. However, the rise of PLR and CA-125 levels in a G population may be used as refer- ring adnexal masses to gynecologic oncologists. PMID: 29943934 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The expression and significance of WT1 in xenotransplanted ovarian carcinoma treated by paclitaxel.
In this study, the authors investigated the expression and significance of WTl in xenotransplanted ovarian carcinoma cell SKOV3 of nude mice treated with paclitaxel. Xenotransplanted ovarian carcinoma was established in nude mice using the SKOV3 cell line. The mice were randomized into the treatment group with paclitaxel and control group with normal sodium. The sizes of the xenotransplanted tumors were measured and the tumor specimens were confirmed by routine hemotoxylin-eosin (H&E) staining. The apoptosis index was then assayed using flow cytometry. WTl and bcl-2 expression were detected with immunohistochemistry, a...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Endometrioid adenocarcinoma arising from adenomyosis: a case report.
CONCLUSION: The malignant transformation of endometriosis is rare, and the mechanisms how it develops on the grounds of adenomyosis is currently unclear. PMID: 29943936 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Total vaginectomy and radical vulvectomy for extension of extra-mammary Paget's disease.
Authors: Kown BS, Ji YI, Jung MH, Kim YS Abstract Extra-mammary Paget's disease of the vulva is a rare non-invasive adenocarcinoma that usually occurs in postmenopausal women. Histologically, it often extends beyond the visible lesion, leading to positive surgical margins and frequent recurrences, but can be managed by simple vulvectomy or wide local excision. Although current evidence supports the use of radical surgery as an alternative to the generally performed wide local excision in the treatment of widely extended extra mammary Paget's disease of the vulva, nonetheless there controversy still exists regarding...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

A mixed carcinoma of the uterus arising from an atypical polypoid adenomyoma: a case report.
In this report, the authors describe the case of a woman with a mixed carcinoma of the uterus arising from an APAM. This case extends our knowledge of the natural pathological course of an APAM and its etiological relationship with a mixed carcinoma of the uterus, which may contribute to the development of management strategies for an APAM. PMID: 29943938 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Ovarian endometrioid carcinoma with yolk sac tumor component in a postmenopausal woman.
Authors: Kabukcuoglu S, Arik D Abstract Yolk sac tumor (YST) coexisting with a variety of histologic patterns have been described, but with an epithelial malignant component is extremely rare. It has been suggested that this rare tumor represents an adenocarcinoma with aberrant differentiation because it occurs in the same age range as epithelial ovarian carcinoma and shows an aggressive behavior and poor prognosis. Although chemotherapy is effective for pure YST, YST with endometrioid adenocarcinoma does not respond to chemotherapy. Here the authors report a postmenopousal women with ovarian endometrioid adenocarc...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Myxoid leiomyosarcoma of the uterus: a case report and review of the literature.
Authors: Zhang L, Li Y, Qu Q, Wen K Abstract A para 1, 52-year-old female was admitted with complaints of irregular vaginal bleeding for the previous six months. Ultrasonography revealed a 4x6-cm tumor extending into the uterine cavity and cervical canal. On vaginal examination, a 2x2-cm tumor protruding from the cervical os was found, and an enlarged uterus was palpated. Vaginal intrauterine tumor resection was performed, and the patient was diagnosed with uterine myxoid leiomyosarcoma. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed, followed by postoperative chemotherapy. Twenty...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Incidental tubal endometrioid adenocarcinoma - case report.
Authors: Varga J, Svajdler P, Dankovcik R, Rabajdova M, Gmitter F, Ostro A Abstract The fallopian tubes represent a highly important structure for ovarian carcinogenesis. They provide the passage of eutopic endometrium from the uterus, as well as metastatic cells from the ovaries. A direct source of tumor cells for ovarian cancer was also recently confirmed in the fallopian tubes. The authors present a case report of an incidental tubal endometrioid carcinoma with the coexistence of adenomyosis. PMID: 29943941 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Rapid enlargement of endometrial stromal sarcoma after uterine fibroid embolization for presumed adenomyosis: a case report and literature review.
Authors: Choi JI, Lee HJ, Shin YJ, Lim HW, Lee HN, Kim M J Abstract Uterine sarcomas have rarely been diagnosed after uterine artery embolization. It remains unclear whether the diagnostic work-up is required prior to such embolization to prevent a missed diagnosis of sarcomas and a delay in providing definitive treatment. Because of the rarity and heterogeneity of endometrial stromal neoplasms, little is known about their epidemiology, pathogenesis, and molecular pathology. The authors report a case of low-grade endometrial stromal sarcoma (ESS) diagnosed after uterine fibroid embolization. Although they performed...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Obturator mononeuropathy due to adenocarcinoma of unknown primary origin.
Authors: Turkoglu R, Gencer M, Aker FV, Meric K, Gokceer SY, Coban A, Tuzun E Abstract A 35-year-old woman presented with a three-month history of left groin and thigh pain. Neurological examination and electromyography showed pathological features consistent with obturator nerve involvement. Imaging studies revealed a left retroperitoneal mass, which by pathological examination was shown to be metastatic adenocarcinoma of possible Mullerian origin. Primary tumor could not be detected in a follow-up period of three years. Obturator mononeuropathy can be the first manifestation of cancer. Cancer of unknown primary o...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

"Gynaecological cancer screening" or "cervical screening?" The case of Hungary.
"Gynaecological cancer screening" or "cervical screening?" The case of Hungary. Eur J Gynaecol Oncol. 2016 08;37(4):445-450 Authors: Döbrőssy L, Koiss R Abstract In Hungary, "gynaecological cancer screening" by gynaecologists having interest in oncology has had a long history. The screening tool was colposcopy alone embedded in complete gynaecological examination. Later on smear-taking for cytology has been added. This screening protocol has survived until now both in the gynaecological community and public. In the meantime, as it proved its ef- fectiveness, cytologi...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Retrospective analysis of the survival benefit of chemotherapy for recurrent or advanced epithelial ovarian carcinoma in patients previously treated with paclitaxel plus platinum-based chemotherapy.
CONCLUSIONS: The PFS of PLD is similar to that of TC. PLD-containing regimens might have a potential benefit with a higher PFS over one year than the TC regimen. PMID: 29894065 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The antibody-based CA125-targeted maintenance therapy for the epithelial ovarian cancer: a meta-analysis.
CONCLUSIONS: CA125-targeted antibody used as maintenance therapy alone is not more effective than placebo but they were safe as maintenance therapy. PMID: 29894066 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The outcomes of radiotherapy in patients with ovarian carcinoma.
Authors: Biedka M Abstract Relapses of ovarian cancer have poor prognosis, overall survival (OS) after recurrence depends on patient's performance status, his- tological cell type, size and number of the relapse, and duration of the platinum-free interval. Pelvis, peritoneum, pleural effusion, liver, lung, lymph nodes, and central nervous system are the most frequent sites of relapse. The standard treatment for ovarian cancer is a com- bination of surgery and chemotherapy. This retrospective study aimed to describe incidence, characteristics, outcomes and prognostic factors of patients with ovarian cancer underwent...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Identification of potential miRNAs and candidate genes of cervical intraepithelial neoplasia by bioinformatic analysis.
CONCLUSIONS: PBXl and LAMC2 may be target genes for CIN. MiR-338, and miR-216 may be key miRNAs in CIN development. PMID: 29894068 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Comparison of the histopathological results of the endometrial thickness detected by transvaginal ultrasound of symptomatic and asymptomatic postmenopausal women.
Authors: Ulu I, Celik A, Haliloğlu B, Ilter E, Midi A Abstract OBJECTIVE: The purpose of the study was to assess the reliability of transvaginal ultrasound (TVUSG) in endometrial pathologies by comparing the ultrasonographic and histopathologic findings in symptomatic and asymptomatic postmenopausal women. MATERIALS AND METHODS: In this retrospective study the data of 129 postmenopausal women that underwent dilatation and curettage was reviewed by dividing them two groups as symptomatic and asymptomatic. Symptomatic group was divided into subgroups according to the value of endometrial thickness obtained by TV...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Health information quality on the internet in gynecological oncology: a multilingual evaluation.
Authors: Lawrentschuk N, Abouassaly R, Hewitt E, Mulcahy A, Bolton DM, Jobling T Abstract BACKGROUND: Oncological internet information quality is considered variable, but no comprehensive analysis of gynecological malig- nancies exists. The present authors' objectives were to compare the quality of common malignancy websites and to assess for language or disease differences; and secondly, to perform a quality comparison between medical and layperson terminology. MATERIALS AND METHODS: World Health Organization (WHO) Health on the Net (HON) principles may be applied to websites using an automated toolbar functio...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Application of Cervista ® human papilloma virus high-risk test in cervical cancer screening of Xinjiang Uyghur women.
CONCLUSION: HR-HPV is closely correlated with cervical cancer and precancerous lesions. Group A9 HPV has a high predictive value in cervical disease screening in Uyghur women. When cytological examination shows atypical squamous cells of undetermined significance (ASCUS), the Cervista® HPV HR test can provide a sensitive differentiation method. PMID: 29894071 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Biweekly administration of docetaxel and carboplatin for advanced or recurrent endometrial and ovarian carcinomas.
CONCLUSION: The present results showed that biweekly administration of docetaxel and carboplatin for advanced and recurrent endometrial and ovarian carcinomas results in acceptable side effects, response rate, and PFS. PMID: 29894072 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Allelic polymorphism in codon 72 of p53 gene: prognosis value, survival rates, and their association with breast cancer.
CONCLUSIONS: This is the first study in the region which shows relationship between genotype polymorphism, survival rate, and its prognosis value in breast cancer. The authors showed that homozygote proline/proline in controls was significantly higher compared with that in the patients. They may therefore, conclude that detection of allelic polymorphisms of codon 72 of the p53 gene including arginine/arginine could be a risk factor predisposition for breast cancer and valuable tool for determining prognosis, progress, and treatment purposes. PMID: 29894073 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Concomitant chemoradiotherapy versus pure radiotherapy in locally advanced cervical cancer: a retrospective analysis of complications and clinical outcome.
Authors: Yang X, Wang J, Lin L, Gao D, Yin L Abstract PURPOSE: To assess the complications and clinical outcomes of concurrent chemoradiotherapy (CCRT) or pure radiotherapy (RT) in local advanced cervical carcinoma (LACC) patients. MATERIALS AND METHODS: A retrospective study was carried out in 113 consecutive LACC (FIGO Stage IB2-IIIB) patients, of whom 68 received CCRT; the others received pure RT. Five-year overall survival (OS) and the incidence, type, and severity of postoperative complications were analyzed. RESULTS: The five-year survival rate for CCRT and pure RT were 67.7% and 46.8%, respectively (...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Incidence of inactive allele CYP2D6*4 among Greek women suffering from hormone-sensitive breast cancer.
CONCLUSION: Although the outcoming results for Greek women are actually in line with existing data for other European nations, it should be noted, that a routine CYP2D6 testing of women suffering from breast cancer is formally not recommended, as the clinical significance of CYP2D6 phenotype in treatment and outcome of breast cancer remains unclear. PMID: 29894075 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Outcomes of concurrent radiotherapy and weekly paclitaxel/carboplatin therapy in cervical cancer: a retrospective study.
CONCLUSIONS: For cervical cancer treatment, CCRT with paclitaxel/car- boplatin is satisfactory. PMID: 29894076 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Detection of high-risk human papillomavirus DNA and immunohistochemical expressions of p16, vimentin, ER, and PR in primary endocervical and endometrial adenocarcinomas.
Authors: Xiong Y, Xiong YY, Xu ZG Abstract OBJECTIVE: The aim of this study was to explore a panel of useful markers in differential diagnosis of primary endocervical adenocarcinoma (ECA) and endometrial adenocarcinoma (EMA). Materials anid Methods: Thirty-three ECAs and 31 EMAs were collected and examined for high-risk human papillomavirus (hr-HPV) (16/18) DNA using in situ hybridization, and for p16, vimentin, ER, PR expression using immunohistochemistry (IHC). RESULTS: Detection rate of hr-HPV (16/18) DNA in ECA (72.7%, 24/33) was significantly higher than that in EMA (12.9%, 4/31) (p
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Comparison of p57, c-erbB-2, CD117, and Bcl-2 expression in the differential diagnosis of hydatidiform mole and hydropic abortion.
Authors: Erol O, Suren D, Tutus B, Yararbas K, Sayiner A, Ozel MK, Derbent AU, Sezer C Abstract PURPOSE: To explore the utility of p57, c-erbB-2, CD 117, and Bel-2 immunostaining in the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA). MATERIALS AND METHODS: Immunohistochemical expression of the p57, c-erbB-2, CD117, and Bel-2 proteins were investigated semi-quantitatively using paraffin-embedded tissue sections from histologically unequivocal cases of CHM (n = 20), PHM (n = 23), and HA (n = 17). RESULTS: All cases of CHM exhibited a str...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Association of estrogen receptor-beta (ESR2) polymorphism and cancer risk: a meta-analysis.
Authors: Xia W, Wang T, Sun D, Mao W, Xie X Abstract Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. However, the results are inconsistent and inconclusive. To examine this controversy, 33 studies were enrolled for the pooled analysis for three poly-morphisms (rs3020450, rs4986938, and rs1256049) in cancer risk using odds ratios (ORs) with 95% confidence intervals (CIs). Regarding rs4986938, A allele was associated...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Study of clinical diagnosis of cervical glandular intraepithelial neoplasia.
Authors: Yang S, Duan W, Kong W, Zhu L, Wu Y Abstract OBJECTIVE: To preliminarily evaluate the clinical significance of different methods in diagnosis of cervical glandular intraepithelial neo- plasia (CGIN). MATERIALS AND METHODS: Clinical manifestations, ThinPrep cytologic test (TCT), cervical biopsy, and pathological features of 106 patients with CGIN admitted to Beijing Obstetrics and Gynecology Hospital between 2008 and 2011 were retrospectively analyzed. RESULTS: Among 146 cases diagnosed with CGIN, 87 (59.6%) had L-CGIN and 59 (40.4%) H-CGIN. Thirty-seven patients (25.6%) were found to have simple CG...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Peritoneal tuberculosis associated with adrenocorticol primitive neoplasm mimicking a peritoneal carcinosis: a case report.
Authors: Lamuraglia M, Barrascout E, Medioni J Abstract The authors report a case of women, 51-year-old that presented with peritoneal tuberculosis, with concomitant adrenocortical primitive neoplasm, mistaken as peritoneal carcinomatosis, due to the failure of correct histological analysis. In fact, the critical life status, associated to increases of CA 125, typical imaging of peritoneal carcinomatosis, and presence of 75% atypical cells in ascitic fluid, induced to begin chemotherapy. PMID: 29894081 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Vulvar melanoma presenting as postmenopausal bleeding: a case report.
Authors: Koumousidis A, Sofoudis C, Marikakis N, Ciopec A, Adamczyk M, Vakis G, Sinha P Abstract Primary melanomas of the vulva are extremely rare, creating obstacles in the differential diagnosis of other epithelial and non-epithelial malignancies. Due to their rarity, there are only approximately 250 cases reported in the current literature. Vulvar melanomas tend to relapse locally, as well as develop locoregional and distant metastasis through lymph node and haematic dissemination. The authors describe a case of an 84-year-old Caucasian female patient, presenting with postmenopausal bleeding, consistent with pri...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Pure non-gestational choriocarcinoma arising in the ovary.
Authors: Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS Abstract Non-gestational choriocarcinoma (NGCO) is a rare primary ovarian cancer with poor prognosis. It is important to distinguish it from gestational ovarian choriocarcinoma (GCO), because there are different treatment options. However, it is difficult to distinguish the two types by routine histologic, ultrastructural, or immunohistochemical examination. The authors present NGCO in a 41-year-old woman, which was confirmed by DNA polymorphism analysis. All tested microsatellite markers had identical DNA profiles with the same allelic sizes between tumor an...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Primary mucinous carcinoma of the vulva with signet ring cells deriving from the cloaca.
Authors: Tulek F, Kahraman A, Taskin S, Yuksel S, Sertcelik A, Ortac F Abstract Vulvar neoplasias are rarely encountered lesions at female genital tract, regardless if they are primary or metastatic. Presence of signet ring cells in a tumour at female genito-urinary tract is highly suggestive of a metastatic lesion particularly from a gastrointestinal tumour. Here the authors present a case of vulvar carcinoma with signet ring cells with an undetermined primary site possibly originating from embryonic cloaca. PMID: 29894084 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Fast and unfavorable course of invasive cancer of the uterine cervix associated with pregnancy despite of a typical treatment. Case report of 35-year-old pregnant multipara.
Authors: Pawlowicz P, Dabrowska M Abstract Carcinoma of the cervix is the most common malignancy associated with pregnancy. The frequency of cervical cancer is estimated to range from 1/1,200 to 1/10,000 pregnancies. The symptoms of cervical cancer are not specific and can be mistaken as frequent symptoms associated with other pathologies of pregnancy. The diagnostic procedure is similar to the one which should be proposed to unpregnant women. The treatment of cervical cancer depends on gestational age. The final treatment and further prognosis is carried out after delivery. The authors present the case of a 35-yea...
Source: European Journal of Gynaecological Oncology - June 15, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research