The role of microRNAs in endometrial cancer and influence on future therapy: focusing on miRNA-21.
Authors: Rak B, Marczewska JM, Wlodarski P Abstract MicroRNAs are small noncoding polynucleotides, which are involved in numerous biological processes including cell proliferation, differentiation, embryonic development, as well as regulation of cell death and survival. Recent investigations have shown impact of microRNAs on cancers prognosis and diagnosis. Current review focused on the role of microRNA-21 in cancers tumorigenesis. Endometrial cancer is the most common gynecological malignancy and the fourth most common in general classification of cancers in Western Europe; thus discovering new molecules may becom...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The significance of the pluripotency and cancer stem cell-related marker NANOG in diagnosis and treatment of ovarian carcinoma.
Authors: Kenda Suster N, Virant-Klun I, Frkovic Grazio S, Smrkolj S Abstract Ovarian cancer is among the most common gynecologic cancers and unfortunately the most common cause of death from gynecologic malignancies. Due to few early symptoms and insufficient screening programs, an early diagnosis of ovarian cancer is very difficult and new biomarkers related to early ovarian carcinogenesis are needed. In the last years a growing scientific knowledge about cancer stem cells and their markers opened a new perspective on screening and early diagnosis of ovarian cancer. The transcription factor NANOG is not only a plu...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Trocar metastases in laparoscopic approach for gynecologic malignancies. A short review of the literature.
CONCLUSIONS: Patient selection is an essential factor that can influence the incidence of port site metastases in gynecological patients. Robust data regarding port site metastases in gynecologic oncology are needed. PMID: 29786996 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Is human epididymis protein 4 an effective tool for the differential diagnosis of benign and malignant endometrial tumours?
This study was designed to evaluate the use of human epididymis protein 4 (HE4) as a biomarker in the differential diagnosis of malignant and benign endometrial tumours. MATERIALS AND METHODS: The study, conducted between July 2009 and June 2014, included a total of 150 patients with endometrioid adenocarcinoma and a control group of 150 patients with benign endometrial lesions. The serum of all patients was analyzed with respect to HE4 and CA125 levels. The median and ranges of serum levels were determined in relation to histological results. The statistical analysis procedure employed in this study utilized logarithm...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Alloplastic breast reconstruction after mastectomy.
Authors: Friedrich M, Swords D, Altgassen C, Baum S, Kramer S Abstract The aim of reconstruction with expanders is to restore breast shape and volume as close as possible to the contralateral breast and to reconstruct the inframammary fold with adequate ptosis. PMID: 29786998 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The effects of bortezomib alone or in combination with 5-fluorouracil on proliferation and apoptosis of choriocarcinoma cells.
Authors: Wang HF, Tong Y, Liu L, Liu HP, Li CD, Liu QR Abstract PURPOSE: To investigate the effects of bortezomib alone and in combination with 5-fluorouracil (5-FU) on proliferation and apoptosis in the human choriocarcinoma cell line JEG-3. MATERIALS AND METHODS: Cells were treated with bortezomib, 5-FU or with a combination. Proliferation and apoptosis were measured. NF-iB protein expression was examined using immunofluorescence. RESULTS: Following treatment with ten nM bortezomib, rates of apoptosis were significantly higher than controls (p
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Negative pressure wound treatment (NPWT) in vulva and groin wounds in gynaecologic oncology.
CONCLUSION: Wound breakdown in vulvar and groin surgery is an infrequent occurrence because of the rarity of full radical excision for vulva cancer and infralevator pelvic exenterative surgery. The present experience with NPWT was favourable. PMID: 29787000 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Secondary cytoreductive surgery, hyperthermic intraperitoneal intraoperative chemotherapy, and chemotherapy alone: a retrospective comparison of alternative approaches in relapsed platinum sensitive ovarian cancer.
CONCLUSIONS: SCR HIPEC compared with CTA improves PFI-2 in patients with platinum-sensitive EOC recurrence. SCR + HIPEC might also improve OS in comparison with CTA. No improvement in favor of SCR + HIPEC vs SCR was observed,. These results further support the need of a randomized trial comparing chemotherapy with SCR ± HIPEC in this setting. PMID: 29787001 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

HPV 16 and 18 viral loads are greater in patients with high-grade cervical epithelial lesions.
CONCLUSIONS: The viral load of HPV-16 was greater than that of HPV-18. The HPV-16 viral load had a moderate positive association in relation to cervical lesion severity, whereas the viral load of HPV- 18 had a weak positive correlation with respect to the cervical lesion grade. PMID: 29787002 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

HPV16 E6 mutations and p53 codon72 polymorphism among women with cervical intraepithelial neoplasia 2 and 3 in China.
CONCLUSION: HPV16 E6 T178G mutation increases the disease risk of CIN2, 3. Meanwhile, compared with Arg/Arg and Arg/Pro genotypes, p53 codon72 Pro/Pro genotype more associated with the disease risk of CIN2, 3. PMID: 29787003 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Effects of salvianolic acid B on growth inhibition and apoptosis induction of ovarian cancer SKOV3.
CONCLUSIONS: Sal B has obvious effects on inhibiting growth and promoting apoptosis of ovarian cancer SKOV3 cell, which may be realized by downregulating livin expression, upregulating caspase-3 expression, and blocking the cell cycle. PMID: 29787004 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Concomitant chemoradiation treatment in selected Stage I endometrioid endometrial cancers.
CONCLUSIONS: Adjuvant concomitant CR is well tolerated and is a feasible regimen in "high risk" patients. The authors' new algorithm treatment could be used for management and further clinical studies. PMID: 29787005 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Risk factors of node metastasis in cervical carcinoma.
CONCLUSION: Patients with tumor size ≥ four cm, stromal invasion ≥ 2/3, LVSI, and parametrial extension were at high risk of lymph node metastasis. PMID: 29787006 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Distant metastases from invasive lobular breast carcinoma classic type - treatment and prognosis.
CONCLUSION: Patients with classic variant of infiltrate lobular cancer of breast should be regularly follow-up, which could permit early diagnosis of distant metastases and improve treatment results. PMID: 29787007 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Laparoendoscopic single-site surgery for the assessment of peritoneal carcinomatosis resectability in patients with advanced ovarian cancer.
CONCLUSION: LESS is feasible, safe, and is an alternative minimally invasive procedure to assess the resectability of AOC patients. PMID: 29787008 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Effect of exemestane on the invasive growth of endometrial carcinoma HHUA cells.
Authors: Wang SG, Meng XM, Dong YZ Abstract OBJECTIVE: To investigate the effect of exemestane on HHUA human endometrial carcinoma cells. MATERIALS AND METHODS: The HHUA human endometrial carcinoma cells were treated with various concentrations of exemestane, and its effects on cell growth and apoptosis were investigated in vitro. The cell apoptosis was analyzed by flow cytometry and RT-PCR was used to investigate the expression of CD44s. The invasion ability of HHUA human endometrial carcinoma cells which treated with exemestane were assessed using transwell chamber model. RESULTS: At increasing doses of e...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Histopathological correlation of splenic disease with radiological and surgical findings: should we incorporate splenectomy into standard procedures for disseminated Millerian adenocarcinoma?
CONCLUSION: Intraoperative identification of splenic disease correlates well with histopathological examination. However, in 50% of splenectomies performed following inadvertent trauma and where disease was not suspected, metastases were identified. PMID: 29787010 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

P16INK4a as a progression/regression tumour marker in LSIL cervix lesions: our clinical experience.
CONCLUSION: p16l4a should help to identify which LSIL cases are inclined to the progression of the disease and focalize which patients are eligible for specific treatment. PMID: 29787011 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

CLC-3 Cl- channel-mediated invasion and migration of human ovarian cancer cells.
CONCLUSIONS: These results strongly suggest that CLC-3 may get involved in proliferation, invasion, and migration of ovarian cancer cells and thus may be a useful therapeutic target. PMID: 29787012 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The trend of chemotherapy-induced peripheral neurotoxicity in ovarian cancer survivors and its impacts on daily life during and one year after treatment.
CONCLUSIONS: A significant proportion of patients with epithelial ovarian cancer treated with carboplatin plus paclitaxel suffer long term neuropathy and it affects patient's daily activities. Specialized care is necessary to provide not only during treatment, but also months to years after drugs withdrawal. PMID: 29787013 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Polymorphism of the CYP2D6 gene in women with breast cancer treated with tamoxifen.
CONCLUSIONS: The present study showed a deficiency in tamoxifen metabolism, characterized by intermediate metabolism in 8% of Brazilian women. PMID: 29787014 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Clinical efficacy analysis of preoperative neoadjuvant chemotherapy with high-dose dense paclitaxel plus cisplatin in Stages IB2, IIA2, IIB cervical cancer in Iran.
CONCLUSION: Combined regimen of chemotherapy in locally advanced cervical cancer proved to be valuable and efficacious without any late complications. PMID: 29787015 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

A case of ovarian small cell carcinoma of the pulmonary type that was observed as it developed.
CONCLUSION: Findings suggested that ovarian small cell carcinoma of the pulmonary type is a type I ovarian malignancy that develops through an adenoma-carcinoma sequence. PMID: 29787016 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Importance of differential diagnosis post-treatment of adenocarcinoma of the uterine cervix: a case report of sarcoidosis.
This study shows the importance of differential diagnosis during the oncologic monitoring of cervical cancer patients to avoid unnecessary treatments at the expense of better therapeutic options. PMID: 29787017 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Primary vaginal endometrial stromal sarcoma associated with endometriosis: a case report with a review of the literature.
In this study, the authors report the sixth case of primary vaginal ESS in the literature and aim to discuss diagnostic criteria and management protocols in the light of the literature. PMID: 29787018 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Apocrine carcinoma of the vulva. Case report and review of literature.
CONCLUSION: Selective sentinel lymph node biopsy may provide a valid option in selected patients to decrease their clinical complications. PMID: 29787019 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Uterine tumors resembling ovarian sex cord tumors: a case report with adenomyosis and complex hyperplasia with atypia.
We report a case of 45-year-old woman with UTROSCT concurrent with adenomyosis and complex hyperplasia with atypia of endometrium and her three-year follow up. PMID: 29787020 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Growing teratoma syndrome: an unusual evolution of treated ovarian immature teratoma - a case report.
Authors: Gomez-Portilla A, Bustamante R, Lopez de Heredia E, Lete LI, Cuadra M, Dominguez S Abstract Growing teratoma syndrome (GTS) is a rare condition among germ cell tumor (GCT) patients during treatment with systemic chemotherapy. It is characterized by the development of enlarging masses, the normalization of tumor markers, and the presence of only mature teratoma in the pathological specimen. The authors present the unusual case of a 15-year-old girl with an immature teratoma treated with conventional surgery and systemic chemotherapy. On her follow up, although tumor markers returned to normal, there was an ...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

An unusual ovarian neoplasm diagnosed in a patient with rupture of unicornuate uterus during pregnancy: a case report.
Authors: Liu TY, Zhu YX, Ke PQ, He M, Liang YC, Yao SZ Abstract Unicornuate uterus is a rare disease characterized with reduced fertility, and ovarian tumor diagnosed during pregnancy is uncommon as well. These two diseases have been reported separately. However, patient suffering from both diseases has never been reported before. The authors herein report a case of a 32-year-old Chinese woman presenting with a unicornuate uterus with no horn, who suffered from acute abdominal pain and intra-abdominal hemorrhage at 26 weeks gestation. Incidentally, a borderline ovarian tumor (BOT) and rupture of uterus were found d...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Selective arterial embolisation for intractable vaginal haemorrhage in genital tract malignancies.
CONCLUSIONS: Since the introduction of SAE the authors have avoided emergency radiotherapy, surgery, and repeat vaginal packing in patients with intractable vaginal bleeding due to gynaecological cancer. Patients were discharged to their appropriate treatment pathways in a timely manner. The authors recommend the application of SAE. PMID: 29787023 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

An unusual enhanced Doppler vascular profile of a rare uterine tumor: PEComa.
Authors: Socolov D, Scripcaru D, Ferariu D, Socolov R, Carauleanu A, Ilea C, Danciu M Abstract PEComas represent a rare class of mesenchymal tumors, with different primary locations. There are less than 100 cases of uterine PEComas published in English literature until now and information considering imaging features of these PEComas is very limited, focusing on CT and MRI and not as much on ultrasounds (US). The authors present here a case of rapidly growing uterine PEComa, with local invasive potential and recurrence, and the review of literature on US characteristics of PEComas. Harboring a hyperechogeneous hete...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Mayer-Rokitansky-Kuster-Hauser syndrome accompanied by invasive ductal carcinoma: a case report.
Authors: Kasap E, Gene M, Sahin N, Sivrikoz ON Abstract Milllerian agenesis and the absence of organs of Millerian canal origin are referred to as Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Invasive ductal carcinoma constitutes 47-75% of all breast carcinomas and is the most common type. The authors report the first case of invasive ductal carcinoma associated with MRKH syndrome in the literature to their knowledge. A 25-year-old woman with a palpable mass in her right breast for three months presented to the presented clinic. On physical examination a mobile, firm mass measuring 2x2 cm was detected in right b...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Abdominal wall mixed malignant germ cell tumor: a case report and review of literature.
Authors: Wei ML, Fan JT, Yu PH, Zhang WJ, Xu H, Liu Y Abstract Abdominal wall mass is not uncommon in clinic, but it is very rare that germ cell tumors (GCTs) arise in the abdominal wall. The authors review the case of a 34-year-old female with abdominal wall mixed malignant GCT composed of embryonal carcinoma and teratoma and combine the relative literature to explain why GCTs originate from anterior abdominal wall. PMID: 29787026 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Malignant mixed germ cell tumor of ovary presenting as advanced disease in an adolescent girl.
Authors: Amirthalingam V, Sharma TD, Rai PC, Singh TT, Devi KP Abstract Mixed germ cell tumors are very rare in young females. Patient survival, preservation of ovarian function and fertility are becoming an important issue. A locally advanced (III), bulky malignant mixed germ cell tumour in a 12-year-old girl presented to the Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur, in January 2011 with abdominal distension for one month. On physical examination, there was a large lower abdominal mass approximately 16x 14 cm2. Abdominal and pelvic CTs showed a lobulated 19x 15x10 cm soft...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Combination therapy of cytotoxic t-lymphocyte-associated antigen 4 (ctla-4) and programmed death 1 (pd 1) blocker, check point inhibitors for treatment of patients with advanced and recurrent epithelial ovarian cancer.
Authors: Farghaly SA Abstract The standard of care for patients with recurrent ovarian cancer is platinum-based combination chemotherapy for those who relapse more than six months after completing adjuvant therapy. The use of biological agents such as bevacizumab has increased progression- free survival (PFS), but has not shown a significant increase in overall survival (OS). Immunotherapy treatment modality is being ac- tively pursued for patients with ovarian cancer. The goal of immunotherapy is to generate a tumor specific, T cell response that decrease residual disease, and protects against future recurrence. C...
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Risk factors to develop multicentric lesions of the lower genital tract.
CONCLUSION: Age, multiparity, contraceptive method, immunodeficiency, and level of studies were significantly correlated with multicentric lesion. Multicentric lesions had an increased risk of recurrence and progression to cancer. PMID: 29767857 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Patterns of recurrence and outcomes in patients with luminal breast cancer: a retrospective study.
CONCLUSIONS: Luminal breast cancer patients with recurrence or/and metastasis had better prognosis after reasonable treatment. These results are of potential clinical relevance, especially for clinical prognosis monitoring and targeted therapy interventions in patients with luminal breast cancer. PMID: 29767858 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Can preoperative neutrophil to lymphocyte and platelet to lymphocyte ratios predict cervical stromal involvement in endometrioid endometrial adenocarcinoma?
Authors: Acikgoz AS, Cakmak B, Tuten A, Oncul M, Eskalen S, Demirkiran F, Arvas M, Guralp O Abstract PURPOSE: To evaluate the possible relationships between preoperative inflammatory markers [neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)] and cervical stromal involvement in endometrioid endometrial adenocarcinoma. MATERIALS AND METHODS: Charts and pathology results of 639 women who were operated on for endometrioid endometrial adenocarcinoma between 2000 and 2013 in the present clinic were retrospectively reviewed. Demographic, laboratory, and clinical parameters were evaluated. ...
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The identification of patients at high risk for recurrent disease after treatment for early-stage cervical cancer.
CONCLUSIONS: Tumor size ≥ 40 mm and lymph node metastasis were independent unfavorable prognostic factors in surgically treated, early-stage cervical cancer patients. The combination of these factors was particularly associated with recurrence. Future trials should focus on the role of alternative adjuvant treatment strategies in patients at high risk of recurrent disease (e.g., by chemotherapy, immunotherapy or combinations thereof). PMID: 29767860 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Serum expression level of cytokine and chemokine correlates with progression of human ovarian cancer.
CONCLUSION: This study suggested that serum expression level of cytokines and chemokines correlate with progression of human ovarian cancer. The association of EGF, MCP-1, 6Ckine, IL-6, and TNF-α may contribute to increase diagnosis rate of malignant ovarian tumors. PMID: 29767861 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Platinum-Gemcitabine-Avastin (PGA) for platinum-resistant/refractory ovarian cancer.
CONCLUSIONS: Combination of PGA appears to be safe and very active against platinum-resistant/refractory ovarian cancer and merits further evaluation prospectively. A randomized phase II study (NCTO 1936974) is currently under way to confirm this important finding. PMID: 29767862 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer.
CONCLUSION: Expression of VEGF, COX-2, and MMP-9 is highly correlated to the mammaographic appearance of spiculation, vascular abnormalities, and lymph node metastasis. However, the present results suggest that expression of VEGF, COX-2, and MMP-9 is either not or weakly correlated to mammographic appereance of calcification. PMID: 29767863 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Hysteroscopy combined dilatation and curettage, serum CA125 and CA19-9 play an important role in preserving fertility or endocrine function for early-stage endometrial cancer patients.
CONCLUSIONS: Hysteroscopy combined D&C should be recommended for early-stage EC patients who desire to preserve fertility or endocrine function, and the preoperative serum levels of CA125 and CA19-9 were powerful in predicting tumor stage in these patients. PMID: 29767864 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The influence of biopsy in cervical high-grade squamous intraepithelial lesion, evaluated by HPV E6/E7 mRNA, Pap test, and conization results.
Conclusions: A higher percentage of negative results were observed in the histopathology, cytopathology, and E6/E7 after biopsy, suggesting that biopsy could affect the regression of CIN. PMID: 29767865 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

HE4: really a novel biomarker for ovarian cancer?.
Authors: Yucel E, Ilter E, Aksungar FB, Celik A, Peker BH, Serifsoy E, Bozkurt S Abstract Ovarian cancer forms 4% of all cancers and approximately 23% of all gynecological cancers in women and is responsible for the 47% of deaths related to cancers of the genital tract of women. Tumor markers are the biochemical substances which can be detected in the presence of tumors. Generally they are either the products of tumoral tissues or secreted from the normal cells which are in the inter- action with tumoral ones. The present authors attempted to determine the efficacy of the tumor marker CA- 125 and HE4 to differentia...
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Expressions of H2AX in cervical squamous carcinoma and their clinical significances.
Authors: Ruan JY, Zhu Q, Mei L, Wang H Abstract OBJECTIVE: To evaluate the expression and clinical significance of H2AX in cervical squamous carcinoma. MATERIALS AND METHODS: The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data. RESULTS: The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlate...
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Knowledge about cervical cancer, Pap test, and barriers to women's participation in screening in Belgrade, Serbia.
CONCLUSION: This study showed that the level of knowledge about CC and Pap test in women is an important factor associated with regular participation in screening. It is necessary to take educational measures in order to raise awareness of women regarding risk factors, as well as to overcome fear and shame, with the ultimate aim to reduce frequency and mortality rate caused by CC in Serbia. PMID: 29767868 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Short-term curative effect and safety of bevacizumab combined with chemotherapy for treating recurrent and metastatic cervical cancer.
CONCLUSIONS: The bevacizumab plus chemotherapy disease control rate for recurrent and metastatic cervical cancer is comparatively high, prolonging median survival; bevacizumab-associated adverse reactions are mild and tolerable. PMID: 29767869 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Surgical staging of low-risk Stage IA endometrioid endometrial cancers.
CONCLUSION: Of the patients, 17.2% had stage migration. Until the issue is solved by future studies, surgical staging might be considered standard surgery for endometrial cancer. PMID: 29767870 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Expression and clinical significance of Ki-67, E-cadherin, and mesothelin in serous borderline ovarian tumor.
This study aimed to investigate the expression of Ki-67, epithelial cadherin (E-cadherin), mesothelin, and their correlations with clinicopathological features of serous borderline ovarian tumors (SBOTs). MATERIALS AND METHODS: Immunohistochemistry was conducted to investigate the expression of a cellular proliferation-related factor (Ki-67) and metastasis-related factors (E-cadherin and mesothelin) in 41 cases of SBOTs, 30 benign ovarian tumor tissues, and 30 malignant ovarian tumor tissues. RESULTS: The results showed that the expression rate of Ki-67 (46.3%) in SBOTs was higher than that in benign tumors (6.7%),...
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research