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The role of oxidative stress in premalignant lesions.
CONCLUSION: The authors demonstrated that increased oxidative stress with altered antioxidant level is associated with abnormal cervical cytology. Serum oxidant and antioxidant status may provide guidance as a simple and cost-effective method for follow-up, treatment, and recommendation in all stages of lesions. PMID: 29953796 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Two unusual cases: vulvar lipoma - description of the largest case in literature. Developing myoma with the longest pedicle.
Authors: Szanecki W, Golonka A, Pajak J, Karcz K, Wróblewska-Czech A, Witek A, Marszałek A, Madry R, Markowska J Abstract The authors present two cases of benign tumors one located on the outer surface of the vulva, and the second extending beyond the vagina. The first, originating from the right pudendal lip, a lipoma measuring 23 cm in greatest diameter, weighing 6.6 kg, and the second a pedunculated, uterine smooth muscle myoma with a pedicle of 6.5 cm, maximum diameter 18 cm, weight 700 grams, which caused significant metroptosis. Operative procedures in each case were free of complications. ...
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Rapidly progressing central-type primitive neuroectodermal tumor of the ovary: a case report.
Authors: Mize B, Salame G, Maglantay R, Chen NN, Lee YC Abstract Primitive neuroectodermal tumors (PNET) belong to a group of highly malignant tumors comprised of small round cells of neu- roectodermal origin. These tumors can be either of peripheral-type (Ewing family tumors/PNET) or central-type. A number of case re- ports have described PNET involving the gynecologic organs and the prognosis is generally poor. The authors describe the case of a 53-year-old woman with a rapidly progressing central-type PNET of the ovary. PMID: 29953798 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

High cellularity and mitotic activity in a primary ovarian fibro-thecomatous tumor of a young patient: a diagnostic and clinical challenge.
CONCLUSIONS: The authors reported the lesion as a hypercellular and mitotically active fibrothecoma. The uneventful follow-up confirms the low malignant potential of the lesion. Caution is required reporting hypercellular stromal ovarian tu- mors, in order to avoid overdiagnosis and overtreatment, particularly in young patients. PMID: 29953799 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Cloacogenic adenocarcinoma of the vulva: one new case and literature review.
Authors: He SR, Deng WH, Yang L, Yang K, Cui D, Liu DG Abstract Primary adenocarcinoma of the vulva is uncommon, and cloacogenic adenocarcinoma of the vulva is extremely rare. Here the authors report a vulvar neoplasm, arising in continuity with the epidermis, characterized by villoglandular architecture, and mucinous-type ep- ithelium with intestinal differentiation (goblet cells). Histochemistry, immunohistochemistry, and gene mutation analysis revealed a colon-like pattern, except for CK7 expression. Extensive workup failed to reveal other primary cancers. In order to provide a much bet- ter experience ...
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research