Immunohistochemical c-kit expression in uterine serous carcinoma tissue.
CONCLUSION: The present results may indicate that primary USC is not a candidate for c-kit targeted therapy. PMID: 29953781 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Application of combined intraperitoneal and intravenous neoadjuvant chemotherapy in senile patients with advanced ovarian cancer and massive ascites.
CONCLUSIONS: Neoadjuvant chemotherapy can obviously shorten the operation duration, reduce the intraoperative blood loss, and improve the ideal success rate of cytoreductive surgery, but does not obviously improve the prognosis. PMID: 29953782 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
CONCLUSION: The present patient population was noticeably older than what has been described in literature, with the majority being postmenopausal. To the authors' knowledge, this is the largest series of postmenopausal patients with SLCT. Hyperandrogenism was evident in only a small sub-group. While the definitive management of SLCT remains controversial and varied, prognosis and risk of recurrence are reassuring. PMID: 29953783 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Direct uterine sampling using the SAP-l sampler device to detect endometrial lesions during histopathological examination.
CONCLUSION: Endometrial sampling using the SAP-l sampler is a minimally invasive altemative technique for obtaining adequate endometrial specimens for histopathological examination. The SAP-l sampler was useful in detecting endometrial carcinoma and atypical hyperplasia cases that were not highly suspected to be localized; however, this method was not useful in detecting endometrial polyps and submucosal leiomyomas. PMID: 29953784 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Central nervous system metastatic epithelial ovarian cancer. Clinical parameters and prognostic factors: a multicenter study of Anatolian Society of Medical Oncology.
Authors: Seber S, Turkmen E, Harputoğlu H, Yeşil H, Arpacι E, Menekşe S, Pilancι K, Oruç Z, Taskoylu BY, Gumusay O, Aksoy A, Karaagac M, Ozarslan E, Yetisyigit T Abstract Central nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients. OBJECTIVE: The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease. MATERIALS AND METHODS: Clinical data of the 33 patients from the participating centers ...
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Lymph node involvement in clinically apparent early ovarian cancer: a prospective study.
CONCLUSION: All patients diagnosed with early OC macroscopically confined to the ovaries should be considered for compre- hensive staging surgery including pelvic and para-aortic lymphadenectomy. PMID: 29953786 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Inhibitory effects of miR-101 overexpression on cervical cancer SiHa cells.
CONCLUSION: miR-101 significantly reduced the viability of SiHa cells as a potential anti-oncogene. PMID: 29953787 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Prevalence of high risk human papillomavirus (HPV) infection and abnormal cervical cytology and knowledge about HPV vaccine in Eastern Turkey.
CONCLUSION: The prevalence of HPV was low in Eastern Turkey and the most common HPV types are similar to the literature. However, the prevalence of HPV infection is a growing problem worldwide and the awareness of the women in the region is limited. PMID: 29953788 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Overexpressed LEDGF is a novel biomarker of poor prognosis in patients with cervical cancer.
In conclusion, the present results suggest that LEDFG expression is an independent prognostic biomarker for cervical cancer. PMID: 29953789 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study.
CONCLUSION: FoxP3 mRNA may not be good diagnostic marker in ovarian tumors; however it may prove valuable in defining underlying tumor molecular signature. PMID: 29953790 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Clinical evaluation of MRI in the differential diagnosis between benign and malignant ovarian tumors.
Authors: Zhang T, Yi X, Lu J, Fu A Abstract Ovarian tumors present a special diagnostic challenge when imaging findings cannot be categorized into benign or malignant pathology. Magnetic resonance imaging (MRI) is currently used to evaluate ovarian tumors. The aim of this study was to evaluate the diagnostic performance of MRI in patients with benign or malignant ovarian tumors and enhance its diagnostic accuracy. The MRI findings of 48 cases of ovarian tumors, which were confirmed by surgery or pathology from September 2009 to July 2011, were analyzed ret- rospectively. Ti-, T2-, and fat-suppressed T2-wei...
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Anatomical variations of the obturator veins and their surgical implications.
CONCLUSIONS: Anatomical variations of the obturator veins appear quite often. PMID: 29953792 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Role and timing of second-line therapies for patients with recurrent platinum-resistant ovarian epithelial cancer.
CONCLUSION: The efficacy of second-line therapy for recurrent platinum-resistant OEC is rather poor and the feasibility and efficacy of second operation are to be further explored. PMID: 29953793 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Suppressing stathmin-l can inhibit chkl protein expression and reduce the invasion and tumorigenicity of cervical cancer cells.
This study found downregulating stathmin-l reduced chkl ex- pressions and the proliferation and invasion in cervical cancer cells and reduced the tumorigenicity of tumor cells. PMID: 29953794 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Hypoxia induces autophagy in PA-l ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum.
In this study the authors analyzed the effect of hypoxia, the autophagy inhibitor 3-methyladenine (3-MA), cis-diamminedichloroplatinum (CDDP, cisplatin), and any combination of them on PA-l cells (a human ovarian cancer cell line) with a series of assays, focusing on autophagy induction, cell growth inhibition, and cell death by CDDP. CDDP caused apoptosis in normoxic PA-l cells and autophagy upon hypoxia treatment decreased apoptosis induction in hypoxic cells by CDDP, which has implications in cancer chemotherapy resistance. PMID: 29953795 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research