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Total 49 results found since Jan 2013.

HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes
This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values of cells were significantly decreased in proliferation assays, cell apoptosis was significantly increased,...
Source: Journal of Obstetrics and Gynaecology - March 27, 2023 Category: OBGYN Authors: Lei Shi Dehui Zhang Huijuan Han Liangyu Zhang Sirui Li Fang Yang Caijun He Source Type: research

Expression of HMGB1-TLR4 in placentas from preeclamptic pregnancies and its effect on proliferation and invasion of HTR-8/SVneo cells
This study aimed to investigate the expression of the high mobility box group 1 (HMGB1)-toll-like receptor 4 (TLR4) signalling pathway in preeclamptic placentas and determine whether HMGB1 regulates the biological behaviour of trophoblasts in vitro. Design: Placental biopsies were taken from 30 preeclamptic patients and 30 normotensive controls. In vitro experiments were carried out in HTR-8/SVneo human trophoblast cells. Participants/Materials, Setting, Methods: HMGB1, TLR4, and nuclear factor kappa B (NF- κB) mRNA and protein were quantified to compare their expression in human placentas from preeclamptic and normot...
Source: Gynecologic and Obstetric Investigation - March 7, 2023 Category: OBGYN Source Type: research

Lipid Management: The Ins and Outs of Inclisiran Lipid Management: The Ins and Outs of Inclisiran
Christopher V. DeSimone, MD, PhD, and Stephen L. Kopecky, MD, discuss lipid management and the use of inclisiran, an siRNA drug that inhibits the RNA from making PCSK9.Mayo Clinic
Source: Medscape ObGyn and Womens Health Headlines - December 5, 2022 Category: OBGYN Tags: Cardiology Commentary Source Type: news

Hypoxia promotes extravillous trophoblast cell invasion through the hypoxia-inducible factor urokinase-type plasminogen activator receptor pathway.
Conclusions: The low oxygen-regulated early events of EVT invasion may be mediated by the HIF-1α-uPAR pathway.
Source: Gynecologic and Obstetric Investigation - July 4, 2022 Category: OBGYN Source Type: research

Overexpression of miR-138-5p Sensitizes Taxol-Resistant Epithelial Ovarian Cancer Cells through Targeting Cyclin-Dependent Kinase 6
Conclusion: In summary, these findings suggest important molecular mechanisms for the miR-138-5p-mediated Taxol sensitivity of ovarian cancer via directly targeting CDK6, suggesting miR-138-5p is an effective therapeutic target for the noncoding RNA-based anti-chemoresistance treatment.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - November 10, 2021 Category: OBGYN Source Type: research

Effect of IL-15-Mediating IFN- γ on HTR-8/SVneo Cells and a Preeclampsia Mouse Model Induced by Lipopolysaccharides
Conclusion: IL-15 inhibition reduced cell apoptosis and increased the invasive and migratory abilities of LPS-induced HTR-8/SVneo cells, thereby alleviating the PE-like phenotype and improving pregnancy outcome.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - June 9, 2021 Category: OBGYN Source Type: research

Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells
ConclusionThis study is the first to reveal that ZEB1-AS1 plays a pivotal role in cancer chemoresistance.
Source: Archives of Gynecology and Obstetrics - April 18, 2021 Category: OBGYN Source Type: research

MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK –STAT signaling pathway by inhibiting JAK3
ConclusionsCollectively, our key findings provide evidence supporting the notion that the overexpression of miR-495 ameliorates inflammatory response and bladder fibrosis in ulcerative IC rat models via inactivation of the JAK –STAT signaling pathway by inhibiting JAK3.
Source: International Urogynecology Journal - January 8, 2021 Category: OBGYN Source Type: research

The diagnostic value and regulatory mechanism of miR-200a targeting ZEB1 in pregnancy-induced hypertension.
Conclusion: MiR-200a was upregulated in PIH patients, andinhibition of miR-200a may improve disease progression, as it could facilitatetrophoblastproliferation, migration and invasionandinhibitapoptosisby targeting ZEB1. PMID: 32345067 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - May 1, 2020 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

H19 regulates angiogenic capacity of extravillous trophoblasts by H19/miR-106a-5p/VEGFA axis
ConclusionH19/miR-106a-5p/VEGFA axis plays a role in regulating the angiogenic capacity of EVT, which might contribute to idiopathic RM.
Source: Archives of Gynecology and Obstetrics - February 26, 2020 Category: OBGYN Source Type: research

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer.
CONCLUSION: LAMC1 overexpression is a potent biomarker for identifying endometrial cancer patients needing aggressive adjuvant therapy. We elucidated 8 candidate genes that may mediate progression of LAMC1 overexpressing cancer. Further investigation of the underlying mechanism should lead to the discovery of new therapeutic targets. PMID: 31912669 [PubMed - as supplied by publisher]
Source: Journal of Gynecologic Oncology - January 10, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Placental supernatants ’ enhancement of the metastatic potential of breast cancer cells: is estrogen receptor (ERα) essential for this phenomenon?
ConclusionsPlacental supernatant facilitates BCCL malignant characteristics by activating ER α in estrogen responsive cells and STAT3 in ERα- BCCL. This indicates a possible mechanism that may underlie PABC’s advanced state and suggests STAT3 pathway as a therapeutic target for PABC.
Source: Archives of Gynecology and Obstetrics - September 25, 2019 Category: OBGYN Source Type: research

Role of Renin-Angiotensin-System in Human Breast Cancer Cells: Is There a Difference in Regulation of Angiogenesis between Hormone-Receptor Positive and Negative Breast Cancer Cells?
Conclusion The RAS-dependent regulation of VEGF between HR-positive and HR-negative breast cancer cells seems do be different. These findings provide evidence for a possible future therapeutic strategy. PMID: 31217631 [PubMed]
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells
ConclusionsCollectively, the findings of this study indicated that FSH promoted glycolysis in epithelial ovarian cancer cells. Knockdown of PKM2 inhibited aerobic glycolysis and cell proliferation induced by FSH.
Source: Archives of Gynecology and Obstetrics - April 20, 2019 Category: OBGYN Source Type: research