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Total 49 results found since Jan 2013.
Enhancement of ovarian cancer chemotherapy by delivery of multidrug‐resistance gene small interfering RNA using tumor targeting Salmonella
ConclusionAttenuated Salmonella typhi may represent a promising vector for in vivo administration of RNA interference therapy against malignant tumors.
Source: Journal of Obstetrics and Gynaecology Research - November 5, 2014 Category: OBGYN Authors: Jiaqi Deng, Yi Guo, Zhongmin Jiang, Min Yang, Huaifang Li, Jianjun Wang Tags: Original Article Source Type: research
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells
ConclusionIt was suggested that HSP70 played functional roles in the progression of uterine cervical SCC, and HSP70 knockdown enhanced chemosensitivities to cisplatin in cervical SCC cells.
Source: Journal of Obstetrics and Gynaecology Research - April 2, 2014 Category: OBGYN Authors: Keiko Yoshidomi, Akihiro Murakami, Kazuyuki Yakabe, Kotaro Sueoka, Shugo Nawata, Norihiro Sugino Tags: Invited Manuscript Source Type: research
Effect of HSP10 on apoptosis induced by testosterone in cultured mouse ovarian granulosa cells
Abstract: Objective: To investigate the effect of heat shock protein 10 (HSP10) on apoptosis induced by testosterone in granulosa cells (GCs) of mouse ovaries in order to define the possible roles of HSP10 in ovarian pathological development of polycystic ovarian syndrome (PCOS) and hyperandrogenic conditions.Study design: Cultured mouse ovarian GCs were treated with testosterone (10−5mol/l). Apoptosis was assessed using flow cytometry, and proliferation was assessed using the MTT assay. HSP10 expression in the treated GCs was detected by real-time polymerase chain reaction (PCR). HSP10 gene was downregulated in the cult...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - October 7, 2013 Category: OBGYN Authors: Kao-Kao Zhao, Yu-Gui Cui, Ya-Qin Jiang, Jing Wang, Mei Li, Yuan Zhang, Xiang Ma, Fei-Yang Diao, Jia-Yin Liu Tags: Reproductive Medicine and Endocrinology Source Type: research
Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells
Conclusions: This study has demonstrated the principle that the simultaneous suppression of c-Src and STAT3 inhibits the growth of epithelial ovarian cancer cells and seems to enhance the cytotoxicity of chemotherapeutic agents in ovarian cancer.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 14, 2013 Category: OBGYN Authors: Shin-Wha Lee, Jin Yoo, Soo-Hyoung Lee, Dongho Kim, Yong-Man Kim, Young-Tak Kim Tags: Gynecology and Gynecological Oncology Source Type: research
