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Total 18 results found since Jan 2013.
APP palmitoylation is involved in the increase in A β < sub > 1-42 < /sub > induced by aluminum
In this study, APP palmitoylation was studied in the setting of aluminum-induced increases in Aβ1-42 from two perspectives: whole animal experiments and in vitro cell experiments. First, the learning and memory of rats were impaired and the number of rat cortical neurons was decreased after staining with aluminum. Second, the expression of palmitoyl APP, APP in lipid rafts and palmitoyl acyltransferase zDHHC7 both in rat cerebral cortex and PC12 cells increased with the production of Aβ1-42 induced by aluminum in a dose-dependent manner. Finally, the intervention with the palmitoylation inhibitors 2-BP and siRNA zDHHC7 i...
Source: Brain Research - November 10, 2021 Category: Neurology Authors: Jing Song Chunman Yuan Wenjing Li Ting Gao Xiaoting Lu Linping Wang Source Type: research
MicroRNA-29a-3p strengthens the effect of dexmedetomidine on improving neurologic damage in newborn rats with hypoxic-ischemic brain damage by inhibiting HDAC4.
CONCLUSION: The study concludes that miR-29a-3p strengthened the effect of Dex on improving neurologic damage in newborn rats with HIBD by inhibiting HDAC4.
PMID: 33232741 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - November 21, 2020 Category: Neurology Authors: Huang W, Xiao F, Huang W, Wei Q, Li X Tags: Brain Res Bull Source Type: research
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer ’s Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2
This study may open new avenues for investigating potential pathognomonics and pathogenesis in AD.
Source: Molecular Neurobiology - September 24, 2020 Category: Neurology Source Type: research
bFGF promotes neurological recovery from neonatal hypoxic –ischemic encephalopathy by IL‐1β signaling pathway‐mediated axon regeneration
ConclusionsWe showed that IL ‐1β‐mediated axon regeneration underlie the mechanism of bFGF for the treatment of HIBD in neonatal rats. Results from this study would provide insights and molecular basis for future therapeutics in treating HIBD.
Source: Brain and Behavior - June 10, 2020 Category: Neurology Authors: Zheng Ma,
Fang Wang,
Lu ‐Lu Xue,
Ying‐Jie Niu,
Yue Hu,
Zhang‐Yu Su,
Jin Huang,
Rui‐Ze Niu,
Ting‐Hua Wang,
Ying‐Chun Ba,
Liu‐Lin Xiong,
Xue Bai Tags: ORIGINAL RESEARCH Source Type: research
FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage
AbstractNeuronal apoptosis is a common and critical pathology following subarachnoid hemorrhage (SAH). We investigated the anti-apoptotic property of fibroblast growth factor (FGF)-2 after SAH in rats. A total of 289 rats underwent endovascular perforation to induce SAH or sham operation. Three dosages (3, 9, or 27 μg) of recombinant FGF-2 (rFGF-2) or vehicle was administered intranasally to rats 30 min after SAH induction. The pan-FGF receptor (FGFR) inhibitor PD173074 or vehicle was administered intracerebroventricularly (i.c.v.) 1 h before modeling, in addition to rFGF-2 treatment. Small interfering ri bonucleic ac...
Source: Molecular Neurobiology - June 14, 2019 Category: Neurology Source Type: research
Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy.
Abstract
Traumatic brain injury (TBI) is a serious insult that frequently leads to neurological impairments. Forkhead box O (FoxO) 3a, as transcription factor, has been confirmed to modulate autophagic process. Moreover, FoxO3a is expressed throughout the brain including the hippocampus. However, the role of FoxO3a in the pathophysiology of TBI is unclear. The present study is designed to investigate whether FoxO3a has the neuroprotective effects on rats subjected to TBI, and further to explore the potential molecular mechanisms. Thus, a rat model of TBI was created by using a modified weight-drop device to mimic ...
Source: Behavioural Brain Research - September 6, 2017 Category: Neurology Authors: Sun L, Zhao M, Liu M, Su P, Zhang J, Li Y, Yang X, Wu Z Tags: Behav Brain Res Source Type: research
Orexin-A aggravates the impairment of hippocampal neurons caused by intermittent hypoxemia by the OXR-PLCβ1-ERK1/2 pathway
Obstructive sleep apnea is a highly prevalent but under-recognized disorder that causes neurocognitive deficits such as spatial memory and learning deficits. These deficits are frequently accompanied by an increase in orexin-A, which has been shown to be involved in learning and memory as well as in neuronal apoptosis in brain areas involved in cognition, such as the hippocampus. The aim of this work was to study the possible harmful effects of orexin-A on intermittent hypoxemia-induced hippocampal neuronal damage and to investigate the potential underlying molecular mechanisms and signaling pathways in vitro. We establish...
Source: NeuroReport - April 3, 2017 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Dynamic association of epigenetic H3K4me3 and DNA 5hmC marks in the dorsal hippocampus and anterior cingulate cortex following reactivation of a fear memory.
Abstract
Epigenetic mechanisms such as DNA methylation and histone methylation are critical regulators of gene transcription changes during memory consolidation. However, it is unknown how these epigenetic modifications coordinate to control gene expression following reactivation of a previously consolidated memory. Here, we found that retrieval of a recent contextual fear conditioned memory increased global levels of H3 lysine 4-trimethylation (H3K4me3) and DNA 5-hydroxymethylation (5hmC) in area CA1 of the dorsal hippocampus. Further experiments revealed increased levels of H3K4me3 and DNA 5hmC within a CpG-enri...
Source: Neurobiology of Learning and Memory - February 19, 2017 Category: Neurology Authors: Webb WM, Sanchez RG, Perez G, Butler AA, Hauser RM, Rich MC, O'Bierne AL, Jarome TJ, Lubin FD Tags: Neurobiol Learn Mem Source Type: research
Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats Basic Sciences
Conclusions—
Exogenous LXA4 inhibited inflammation by activating FPR2 and inhibiting p38 after SAH. LXA4 may serve as an alternative treatment to relieve early brain injury after SAH.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Guo, Z., Hu, Q., Xu, L., Guo, Z.-N., Ou, Y., He, Y., Yin, C., Sun, X., Tang, J., Zhang, J. H. Tags: Animal Models of Human Disease Basic Sciences Source Type: research
Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion
Abstract
IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to the phosphor...
Source: Molecular Neurobiology - January 7, 2016 Category: Neurology Source Type: research
Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway
Abstract
Bisphenol A (BPA) is an environmental xenoestrogenic endocrine disruptor, utilized for production of consumer products, and exerts adverse effects on the developing nervous system. Recently, we found that BPA impairs the finely tuned dynamic processes of neurogenesis (generation of new neurons) in the hippocampus of the developing rat brain. Curcumin is a natural polyphenolic compound, which provides neuroprotection against various environmental neurotoxicants and in the cellular and animal models of neurodegenerative disorders. Here, we have assessed the neuroprotective efficacy of curcumin against BPA-m...
Source: Molecular Neurobiology - May 12, 2015 Category: Neurology Source Type: research
Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala
Publication date: Available online 26 February 2015 Source:Brain, Behavior, and Immunity Author(s): Stacey L. Kigar , Liza Chang , Anthony P. Auger Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowled...
Source: Brain, Behavior, and Immunity - March 4, 2015 Category: Neurology Source Type: research
Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala.
Abstract
Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowledge, no study has been done investigating the involvement of Gadd45b in neurodevelopmental programming of social behavior. To address...
Source: Brain, Behavior, and Immunity - February 26, 2015 Category: Neurology Authors: Kigar SL, Chang L, Auger AP Tags: Brain Behav Immun Source Type: research
β-asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice.
Abstract
β-asarone is an active component of the Acori graminei rhizome that is a traditional Chinese medicine clinically used in treating dementia in China. However, the cognitive effect of β-asarone and its mechanism has remained elusive. Here, we used asenescence-accelerated prone 8 (SAMP8) mice, which mimic many of the salient features of Alzheimer's disease (AD), to further investigate whether modulation of the ROCK signaling pathway and/or autophagy, synaptic loss is involved in the effects of β-asarone on learning and memory. SAMP8 mice at the age of 6 months were intragastrically administered by β-asar...
Source: Brain Research - January 20, 2014 Category: Neurology Authors: Chen Y, Wei G, Nie H, Lin Y, Tian H, Liu Y, Yu X, Cheng S, Yan R, Wang Q, Hui Liu D, Deng W, Lai Y, Hong Zhou J, Xia Zhang S, Wei Lin W, Feng Chen D Tags: Brain Res Source Type: research
