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Specialty: Neurosurgery

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Total 63 results found since Jan 2013.

Gliomagenesis is orchestrated by the Oct3/4 regulatory network
J Neurosurg Sci. 2021 Aug 3. doi: 10.23736/S0390-5616.21.05437-0. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a lethal brain tumor characterized by developmental hierarchical phenotypic heterogeneity, therapy resistance and recurrent growth. Neural stem cells (NSCs) from human central nervous system (CNS), and glioblastoma stem cells from patient-derived GBM (pdGSC) samples and cultured in both 2D well-plate and 3D monoclonal neurosphere culture system (pdMNCS). The pdMNCS model shows promise to establish a relevant 3D-tumor environment that maintains GBM cells in the stem cell phase within suspended neu...
Source: Journal of Neurosurgical Sciences - August 3, 2021 Category: Neurosurgery Authors: Tatyana N Ignatova Hersh J Chaitin Nickolay V Kukekov Oleg N Suslov Galina I Dulatova Khalid A Hanafy Frank D Vrionis Source Type: research

Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma
Conclusion High throughput with in vitro combination screening is feasible with chordoma cells and allows for rapid identification of synergistic dual-therapies. Potential combination therapies and targetable pathways were identified. T (brachyury) knockdown produced significant reduction in cell viability, but did not show additional benefit with PI3K pathway inhibition in this model. Further in vitro and in vivo validation of these therapeutic combinations is warranted. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - October 12, 2020 Category: Neurosurgery Authors: Heft Neal, Molly E. Michmerhuizen, Nicole L. Kovatch, Kevin J. Owen, John Henry J. Zhai, Jingyi Jiang, Hui McKean, Erin L. Prince, Mark E.P. Brenner, J. Chad Tags: Original Article Source Type: research

Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.
CONCLUSIONS: CD146 is a potential therapeutic target, and folic acid-conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas. PMID: 32707539 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 23, 2020 Category: Neurosurgery Authors: Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, Yamashita T, Aratake T, Honke K, Ueba T Tags: J Neurosurg Source Type: research

Annexin A7 induction of neuronal apoptosis via effect on glutamate release in a rat model of subarachnoid hemorrhage.
CONCLUSIONSANXA7 can induce neuronal apoptosis by affecting glutamate release in rats with SAH. Downregulating the expression of ANXA7 can significantly attenuate early brain injury after SAH. Future therapy targeting ANXA7 may be a promising new choice. PMID: 30717037 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 1, 2019 Category: Neurosurgery Authors: Lin QS, Wang WX, Lin YX, Lin ZY, Yu LH, Kang Y, Kang DZ Tags: J Neurosurg Source Type: research

Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma.
CONCLUSIONSOur findings suggest IGFBP3 predicts poor outcome of glioma patients and is a potential therapeutic target for which depletion of its expression suppresses tumor growth through inducing apoptosis and accumulation of DNA damage in glioma cells. PMID: 30641835 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 11, 2019 Category: Neurosurgery Authors: Chen CH, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC Tags: J Neurosurg Source Type: research

Targeting GRP78 as a Basis for Enhanced Glioma Cells Killing by anti-TfR antibody.
CONCLUSION: Our results show that the anti-tumor effects of anti-TfR antibody trigger the ER stress response, and that this effect is achieved via the siRNA against GRP78 for glioma cell growth and survival. These results hold promise as a clinical approach to gene therapy for malignant gliomas. PMID: 29091247 [PubMed - as supplied by publisher]
Source: Turkish Neurosurgery - October 2, 2017 Category: Neurosurgery Authors: Wen X, Cheng X, Wu S Tags: Turk Neurosurg Source Type: research

Memantine Induces NMDAR1-Mediated Autophagic Cell Death in Malignant Glioma Cells.
CONCLUSION: Our study demonstrates that in glioma cells, memantine inhibits proliferation and induces autophagy mediated by NMDAR1. PMID: 28264232 [PubMed - in process]
Source: Journal of Korean Neurosurgical Society - March 9, 2017 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

(Pro)renin receptor is crucial for glioma development via the Wnt/ β-catenin signaling pathway.
CONCLUSIONS This is the first evidence that the PRR has an important role in development of glioma by aberrant activation of the Wnt/β-catenin signaling pathway. This receptor may be both a prognostic marker and a therapeutic target for glioma. PMID: 28059652 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2017 Category: Neurosurgery Authors: Kouchi M, Shibayama Y, Ogawa D, Miyake K, Nishiyama A, Tamiya T Tags: J Neurosurg Source Type: research

Drug priming enhances radiosensitivity of adamantinomatous craniopharyngioma via downregulation of survivin.
CONCLUSIONS These results indicate an impact of EGFR signaling on radioresistance in ACP. Inhibition of EGFR activity by means of TKI treatment acts as a radiosensitizer on ACP tumor cells, leading to increased cell death. Additionally, the results emphasize the antiapoptotic and pro-proliferative role of survivin in ACP biology and its regulation by EGFR signaling. The suppression of survivin by treatment with TKI and combined radiotherapy represents a new promising treatment strategy that will be further assessed in in vivo models of ACP. PMID: 27903123 [PubMed - in process]
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Stache C, Bils C, Fahlbusch R, Flitsch J, Buchfelder M, Stefanits H, Czech T, Gaipl U, Frey B, Buslei R, Hölsken A Tags: Neurosurg Focus Source Type: research

Patisiran ph 2 open-label extension study in familial amyloidotic polyneuropathy
Conclusion Data demonstrates that 18-months of patisiran administration was generally well tolerated, resulted in sustained mean serum TTR lowering, supporting the hypothesis that TTR knockdown potentially halts neuropathy progression.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Schmidt, H., Adams, D., Coelho, T., Conceicao, I., Waddington-Cruz, M., Buades, J., Campistol, J., Pouget, J., Gollob, J., Suhr, O. Tags: Genetics, Neuromuscular disease, Peripheral nerve disease ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells.
CONCLUSIONS The authors propose that inhibiting PDIA6 could transduce EGFR signaling by activating and inducing ADAM17 during migration and invasion of U87MG glioblastoma cells. The results of this study suggest that PDIA6 is an important component of EGFR-mediated migration and invasion of U87MG cells. This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma. PMID: 27540907 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 18, 2016 Category: Neurosurgery Authors: Kim TW, Ryu HH, Li SY, Li CH, Lim SH, Jang WY, Jung S Tags: J Neurosurg Source Type: research