Filtered By:
Specialty: Neurosurgery

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 63 results found since Jan 2013.

RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
CONCLUSIONS Treating glioblastoma with siRNA targeting HIF-1α in vivo can significantly reduce tumor growth and increase survival in an intracranial mouse model, a finding that has direct clinical implications. PMID: 25423275 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 25, 2014 Category: Neurosurgery Authors: Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL Tags: J Neurosurg Source Type: research

Targeting GRP78 as a Basis for Enhanced Glioma Cells Killing by anti-TfR antibody.
CONCLUSION: Our results show that the anti-tumor effects of anti-TfR antibody trigger the ER stress response, and that this effect is achieved via the siRNA against GRP78 for glioma cell growth and survival. These results hold promise as a clinical approach to gene therapy for malignant gliomas. PMID: 29091247 [PubMed - as supplied by publisher]
Source: Turkish Neurosurgery - October 2, 2017 Category: Neurosurgery Authors: Wen X, Cheng X, Wu S Tags: Turk Neurosurg Source Type: research

PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells.
CONCLUSIONS The authors propose that inhibiting PDIA6 could transduce EGFR signaling by activating and inducing ADAM17 during migration and invasion of U87MG glioblastoma cells. The results of this study suggest that PDIA6 is an important component of EGFR-mediated migration and invasion of U87MG cells. This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma. PMID: 27540907 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 18, 2016 Category: Neurosurgery Authors: Kim TW, Ryu HH, Li SY, Li CH, Lim SH, Jang WY, Jung S Tags: J Neurosurg Source Type: research

Drug priming enhances radiosensitivity of adamantinomatous craniopharyngioma via downregulation of survivin.
CONCLUSIONS These results indicate an impact of EGFR signaling on radioresistance in ACP. Inhibition of EGFR activity by means of TKI treatment acts as a radiosensitizer on ACP tumor cells, leading to increased cell death. Additionally, the results emphasize the antiapoptotic and pro-proliferative role of survivin in ACP biology and its regulation by EGFR signaling. The suppression of survivin by treatment with TKI and combined radiotherapy represents a new promising treatment strategy that will be further assessed in in vivo models of ACP. PMID: 27903123 [PubMed - in process]
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Stache C, Bils C, Fahlbusch R, Flitsch J, Buchfelder M, Stefanits H, Czech T, Gaipl U, Frey B, Buslei R, Hölsken A Tags: Neurosurg Focus Source Type: research

(Pro)renin receptor is crucial for glioma development via the Wnt/ β-catenin signaling pathway.
CONCLUSIONS This is the first evidence that the PRR has an important role in development of glioma by aberrant activation of the Wnt/β-catenin signaling pathway. This receptor may be both a prognostic marker and a therapeutic target for glioma. PMID: 28059652 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2017 Category: Neurosurgery Authors: Kouchi M, Shibayama Y, Ogawa D, Miyake K, Nishiyama A, Tamiya T Tags: J Neurosurg Source Type: research

Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.
CONCLUSIONS: CD146 is a potential therapeutic target, and folic acid-conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas. PMID: 32707539 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 23, 2020 Category: Neurosurgery Authors: Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, Yamashita T, Aratake T, Honke K, Ueba T Tags: J Neurosurg Source Type: research

Propranolol Inhibits the Proliferation of Human Glioblastoma Cell Lines through Notch1 and Hes1 Signaling System
CONCLUSION: These results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.PMID:34376038 | DOI:10.3340/jkns.2021.0068
Source: Journal of Korean Neurosurgical Society - August 11, 2021 Category: Neurosurgery Authors: Hyun Sik Kim Young Han Park Heui Seung Lee Mi Jung Kwon Joon Ho Song In Bok Chang Source Type: research

COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion
CONCLUSIONS: COL1A2 plays an important role in driving GBM progression. COL1A2 inhibition attenuated GBM proliferation by promoting cell cycle arrest, indicating that COL1A2 could be a promising therapeutic target for GBM treatment.PMID:35932265 | DOI:10.3171/2022.6.JNS22319
Source: Journal of Neurosurgery - August 6, 2022 Category: Neurosurgery Authors: Yi Wang Maki Sakaguchi Hemragul Sabit Sho Tamai Toshiya Ichinose Shingo Tanaka Masashi Kinoshita Yasuo Uchida Sumio Ohtsuki Mitsutoshi Nakada Source Type: research