RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.

CONCLUSIONS Treating glioblastoma with siRNA targeting HIF-1α in vivo can significantly reduce tumor growth and increase survival in an intracranial mouse model, a finding that has direct clinical implications.
PMID: 25423275 [PubMed - as supplied by publisher]

Source: Journal of Neurosurgery - November 25, 2014 Category: Neurosurgery Authors: Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL Tags: J Neurosurg Source Type: research