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Specialty: Neurosurgery
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Total 63 results found since Jan 2013.
Gliomagenesis is orchestrated by the Oct3/4 regulatory network
J Neurosurg Sci. 2021 Aug 3. doi: 10.23736/S0390-5616.21.05437-0. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a lethal brain tumor characterized by developmental hierarchical phenotypic heterogeneity, therapy resistance and recurrent growth. Neural stem cells (NSCs) from human central nervous system (CNS), and glioblastoma stem cells from patient-derived GBM (pdGSC) samples and cultured in both 2D well-plate and 3D monoclonal neurosphere culture system (pdMNCS). The pdMNCS model shows promise to establish a relevant 3D-tumor environment that maintains GBM cells in the stem cell phase within suspended neu...
Source: Journal of Neurosurgical Sciences - August 3, 2021 Category: Neurosurgery Authors: Tatyana N Ignatova Hersh J Chaitin Nickolay V Kukekov Oleg N Suslov Galina I Dulatova Khalid A Hanafy Frank D Vrionis Source Type: research
Cyclin-dependent kinase inhibitor 2A (CDKN2A) is a key regulator of cell cycle arrest and senescence in endothelial colony-forming cells (ECFCs) in moyamoya disease (MMD)
CONCLUSION: Our study suggests that CDKN2A plays an important role in the growth retardation of MMD ECFCs by inducing cell cycle arrest and senescence.PMID:37138505 | DOI:10.3340/jkns.2023.0005
Source: Journal of Korean Neurosurgical Society - May 4, 2023 Category: Neurosurgery Authors: Seung Ah Choi Youn Joo Moon Eun Jung Koh Ji Hoon Phi Ji Yeoun Lee Kyung Hyun Kim Seung-Ki Kim Source Type: research
