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Specialty: Neurosurgery
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Total 63 results found since Jan 2013.
E-258 Endovascular approach to drug delivery to the brain
ConclusionsCPA delivery of AAV9 resulted in increased transduction of the parietal and cingulate cortex, comparable to that observed with CM injections. These results provide preliminary evidence that CPA infusion of gene therapy, and potentially other therapies such as antisense oligonucleotides or siRNA medications, is safe and provides widespread distribution throughout the brain.Abstract E-258 Figure 1Disclosures A. Malek: 4; C; CereVasc. H. Benatti: None. V. Anagnostakou: None. E. Hall: None. C. Heilman: 4; C; CereVasc. B. Beneduce: 4; C; CereVasc. A. Leporati: None. R. King: None. M. Gounis: 1; C; Research support fr...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Malek, A., Benatti, H., Anagnostakou, V., Hall, E., Heilman, C., Beneduce, B., Leporati, A., King, R., Gounis, M., Gray-Edwards, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
Cyclin-dependent kinase inhibitor 2A (CDKN2A) is a key regulator of cell cycle arrest and senescence in endothelial colony-forming cells (ECFCs) in moyamoya disease (MMD)
CONCLUSION: Our study suggests that CDKN2A plays an important role in the growth retardation of MMD ECFCs by inducing cell cycle arrest and senescence.PMID:37138505 | DOI:10.3340/jkns.2023.0005
Source: Journal of Korean Neurosurgical Society - May 4, 2023 Category: Neurosurgery Authors: Seung Ah Choi Youn Joo Moon Eun Jung Koh Ji Hoon Phi Ji Yeoun Lee Kyung Hyun Kim Seung-Ki Kim Source Type: research
COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion
CONCLUSIONS: COL1A2 plays an important role in driving GBM progression. COL1A2 inhibition attenuated GBM proliferation by promoting cell cycle arrest, indicating that COL1A2 could be a promising therapeutic target for GBM treatment.PMID:35932265 | DOI:10.3171/2022.6.JNS22319
Source: Journal of Neurosurgery - August 6, 2022 Category: Neurosurgery Authors: Yi Wang Maki Sakaguchi Hemragul Sabit Sho Tamai Toshiya Ichinose Shingo Tanaka Masashi Kinoshita Yasuo Uchida Sumio Ohtsuki Mitsutoshi Nakada Source Type: research
Propranolol Inhibits the Proliferation of Human Glioblastoma Cell Lines through Notch1 and Hes1 Signaling System
CONCLUSION: These results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.PMID:34376038 | DOI:10.3340/jkns.2021.0068
Source: Journal of Korean Neurosurgical Society - August 11, 2021 Category: Neurosurgery Authors: Hyun Sik Kim Young Han Park Heui Seung Lee Mi Jung Kwon Joon Ho Song In Bok Chang Source Type: research
