Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma.

CONCLUSIONSOur findings suggest IGFBP3 predicts poor outcome of glioma patients and is a potential therapeutic target for which depletion of its expression suppresses tumor growth through inducing apoptosis and accumulation of DNA damage in glioma cells. PMID: 30641835 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30641835?dopt=Abstract

Source: Journal of Neurosurgery - January 11, 2019 Category: Neurosurgery Authors: Chen CH, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC Tags: J Neurosurg Source Type: research