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Specialty: Neurosurgery

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Total 63 results found since Jan 2013.

Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells.
CONCLUSION: Taken together, our results suggested that sildenafil provides beneficial effect to protect the HT-22 hippocampal neuronal cells against AGE-induced deterioration of mitochondrial integrity, and upregulation of HO-1 is involved in the underlying mechanism. PMID: 27226858 [PubMed]
Source: Journal of Korean Neurosurgical Society - May 27, 2016 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Phase 2 open-label extension study of patisiran, an investigational rnai therapeutic for the treatment of familial amyloid polyneuropathy
Familial amyloid polyneuropathy (FAP) is a progressive disease. Patisiran is an investigational small interfering RNA (siRNA) targeting TTR. The primary objective of the Phase 2 study is to evaluate the safety of 0.3 mg/kg patisiran administered intravenously once every 3 weeks. Twenty-seven patients were enrolled; the mean duration of treatment was 7 months (range 3–12), with 282 doses administered (median of 11 doses/patient). Chronic dosing with patisiran has been generally well tolerated. Two patients experienced serious adverse events regarded as being unrelated to study drug. Infusion-related reactions wer...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Adams, D., Suhr, O., Conceicao, I., Waddington-Cruz, M., Schmidt, H., Buades, J., Campistol, J., Pouget, J., Berk, J., Coelho, T. Tags: Genetics, Neuromuscular disease, Peripheral nerve disease Wed 20, Parallel session 4: Disease pathophysiology Source Type: research

RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
CONCLUSIONS Treating glioblastoma with siRNA targeting HIF-1α in vivo can significantly reduce tumor growth and increase survival in an intracranial mouse model, a finding that has direct clinical implications. PMID: 25423275 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 25, 2014 Category: Neurosurgery Authors: Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL Tags: J Neurosurg Source Type: research