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Harmine loaded Au@MSNs@PEG@Asp6 nano-composites for treatment of spinal metastasis from lung adenocarcinoma by targeting ANXA9 < em > in vivo < /em > experiment
CONCLUSIONS: ANXA9 may serve as a novel biomarker for predicting poor prognosis in LUAD, and we provided an efficient and targeting drug delivery nano-composites system for precise treatment of SM from LUAD.PMID:37323183 | PMC:PMC10261857 | DOI:10.21037/tlcr-23-191
Source: Cell Research - June 16, 2023 Category: Cytology Authors: Houlei Wang Fancheng Chen Annan Hu Haifeng Liang Yun Liang Nagashree Seetharamu Huiren Wang Jian Dong Source Type: research

Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Cell Research - July 25, 2022 Category: Cytology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research

Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1 α
CONCLUSION: Our findings suggest that KRGE exhibits prophylactic potential by stimulating astrocyte mitochondrial biogenesis through HIF-1α, resulting in improved neurovascular function.PMID:35600778 | PMC:PMC9120627 | DOI:10.1016/j.jgr.2021.07.003
Source: Cell Research - May 23, 2022 Category: Cytology Authors: Jinhong Park Minjae Lee Minsu Kim Sunhong Moon Seunghee Kim Sueun Kim Seong-Ho Koh Young-Myeong Kim Yoon Kyung Choi Source Type: research

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
CONCLUSION: SDP protected renal tubular epithelial cells from cell pyroptosis and EMT by regulating the albumin-induced mitochondrial dysfunction/ MAVS/ NLRP3-ASC-caspase-1 inflammasome signaling pathway.PMID:34908861 | PMC:PMC8665879 | DOI:10.2147/JIR.S341598
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Yiye Zhu Guoshun Huang Yang Yang Chen Yong Xiang Yu Gang Wang Lan Yi Kun Gao Fang Tian Shushu Qian Enchao Zhou Yanqin Zou Source Type: research

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Cell Research - December 6, 2021 Category: Cytology Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research

Tripterygium glycoside protects diabetic kidney disease mouse serum-induced podocyte injury by upregulating autophagy and downregulating β-arrestin-1.
CONCLUSIONS: This study demonstrated that tripterygium glycoside provided protection against podocyte injury induced by high-glucose serum, and that this effect was mediated by the concomitant activation of autophagy and downregulation of β-arrestin-1. PMID: 30839094 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - March 7, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research

ADAM17 Participates in the Protective Effect of Paeoniflorin on Mouse Brain Microvascular Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Haifang Wang, Shuhui Ma, Jing Li, Miaomiao Zhao, Xueping Huo, Jingying Sun, Lijun Sun, Jun Hu, Qinshe Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis
Conclusion: Results provided novel preclinical insights into the chemotherapeutic use of GA by highlighting the importance of p66shc/ROS-p53/Bax pathways in the antitumor effect of GA in malignant melanoma.Cell Physiol Biochem 2016;38:1618-1630
Source: Cellular Physiology and Biochemistry - April 27, 2016 Category: Cytology Source Type: research

Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress.
Abstract Costunolide is an active sesquiterpene lactone derived from many herbal medicines. It has a broad spectrum of bioactivities, including anti-inflammatory and potential anti-tumor effects. The aims of the present study were to evaluate the inhibitory effects of costunolide on A549 cell growth and to explore the underlying molecular mechanisms. Annexin V-FITC/PI flow cytometry analysis revealed that costunolide induced apoptosis. To study the mechanism, we found that costunolide exposure activated the unfolded protein response (UPR) signaling pathways, as shown by the up-regulation of GRP78 and IRE1α and th...
Source: Cell Biology International - November 26, 2015 Category: Cytology Authors: Wang Z, Zhao X, Gong X Tags: Cell Biol Int Source Type: research

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.Cell Physiol Biochem 2015;36:956-965
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway
Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.Cell Physiol Biochem 2015;36:893-906
Source: Cellular Physiology and Biochemistry - June 9, 2015 Category: Cytology Source Type: research

Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells
In this study, we investigated the effects of TIIA on LPS-induced acute lung inflammation, as well as its relationship to Muc1 expression in mouse lung and MUC1 in human alveolar epithelial cells. TIIA pretreatment significantly inhibited LPS-induced pulmonary inflammation in both Muc1 wild-type (Muc1+/+) and knockout (Muc1–/–) mice, as manifested by reduced neutrophil infiltration and reduced TNF-α and keratinocyte chemoattractant levels in bronchoalveolar lavage fluid. The inhibitory effects of TIIA on airway inflammation were associated with reduced expression of Muc1 in Muc1+/+ mouse lung. Moreover, p...
Source: AJP: Cell Physiology - January 1, 2014 Category: Cytology Authors: Zhang, K., Wang, J., Jiang, H., Xu, X., Wang, S., Zhang, C., Li, Z., Gong, X., Lu, W. Tags: ARTICLES Source Type: research

Tanshinone IIA inhibits lipopolysacharide-induced MUC1 overexpression in alveolar epithelial cells.
In this study, we investigated the effects of TIIA on lipopolysaccharide (LPS)-induced acute lung inflammation, as well as its relationship to Muc1 expression in mouse lung and MUC1 in human alveolar epithelial cells. TIIA pretreatment significantly inhibited LPS-induced pulmonary inflammation in both Muc1 wild type (Muc1(+/+)) and knockout (Muc1(-/-)) mice, as manifested by reduced neutrophils infiltration, and reduced TNF-α and KC levels in bronchoalveolar lavage (BAL) fluid. The inhibitory effects of TIIA on airway inflammation were associated with reduced expression of Muc1 in Muc1(+/+) mouse lung. Moreover, pretreatm...
Source: American Journal of Physiology. Cell Physiology - October 23, 2013 Category: Cytology Authors: Zhang K, Wang J, Jiang H, Xu X, Wang S, Zhang C, Li Z, Gong X, Lu W Tags: Am J Physiol Cell Physiol Source Type: research

Salvianolic Acid B Induces Apoptosis in Human Glioma U87 Cells Through p38-Mediated ROS Generation.
Abstract Salvianolic acid B (SalB), the main water-soluble bioactive compounds isolated from the traditional Chinese medical herb Danshen, has been shown to exert anti-cancer effect in several cancer cell lines. The aim of our study was to investigate the potential anti-cancer effect of SalB in human glioma U87 cells. We found that treatment with SalB significantly decreased cell viability of U87 cells in a dose- and time-dependent manner. SalB also enhanced the intracellular ROS generation and induced apoptotic cell death in U87 cells. Western blot analysis suggested that SalB increased the phosphorylation of p38...
Source: Cellular and Molecular Neurobiology - July 11, 2013 Category: Cytology Authors: Wang ZS, Luo P, Dai SH, Liu ZB, Zheng XR, Chen T Tags: Cell Mol Neurobiol Source Type: research

Ephedrine induced Thioredoxin-1 expression through β-adrenergic receptors/Cyclic AMP/protein kinase A/dopamine- and Cyclic AMP-regulated phosphoprotein signaling pathway.
In this study, we found that Eph induced Trx-1 expression, which was inhibited by propranolol (β-adrenergic receptors inhibitor), but not by phenoxybenzamine (α-adrenergic receptors inhibitor) in rat pheochromocytoma PC12 cells. Moreover, the increase of Trx-1 expression was inhibited by SQ22536 (adenylyl cyclase inhibitor) and H-89 (protein kinase A inhibitor). Interestingly, the effect of Eph on dopamine- and Cyclic AMP-regulated phosphoprotein (DARPP-32) was similar to Trx-1. Thus, the relationship between Trx-1 and DARPP-32 was further studied. The DARPP-32 siRNA significantly reduced Trx-1 expression, but Trx-1 siRN...
Source: Cellular Signalling - February 14, 2013 Category: Cytology Authors: Jia JJ, Zeng XS, Li Y, Ma S, Bai J Tags: Cell Signal Source Type: research