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Nutrition: Soy isoflavones

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Total 46 results found since Jan 2013.

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver
In conclusion, our findings show that CME is the mechanism responsible for the internalization of the canalicular transporters BSEP and MRP2 in E17G-induced cholestasis. The shift of these transporters from raft to non-raft microdomains could be a prerequisite for the transporters to be endocytosed under cholestatic conditions.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - March 1, 2018 Category: Molecular Biology Source Type: research

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.
Authors: Zhu J, Ren J, Tang L Abstract Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, incre...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 18, 2018 Category: Biochemistry Source Type: research

Genistein suppresses psoriasis-related inflammation through a STAT3-NF- κB-dependent mechanism in keratinocytes.
In this study, we investigated the effects of genistein on imiquimod (IMQ)-induced psoriasis-like skin lesions in vivo and explored the mechanisms underlying those effects in vitro. It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23. In vitro studies, genistein inhibited the proliferation of human keratinocyte HaCaT cells and inhibited the expression of inf...
Source: International Immunopharmacology - February 8, 2019 Category: Allergy & Immunology Authors: Wang A, Wei J, Lu C, Chen H, Zhong X, Lu Y, Li L, Huang H, Dai Z, Han L Tags: Int Immunopharmacol Source Type: research

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
In conclusion, for the first time, our study suggested that genistein has anticarcinoma effect for PTC patients in the range of 2.5 and 80 μg/ml in thyroid carcinoma cells, which was probably through cytoplasmic translocation of β-catenin. Further study will be needed to determine whether genistein could be used in clinical trial of high-risk PTC.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyan Zhang, Bin Lv, Cuihua Yi, Xiujie Cui, Shaofeng Sui, Xueen Li, Mei Qi, Chunyan Hao, Bo Han, Zhiyan Liu Tags: Research Paper Source Type: research

The Laminin-Induced Phosphorylation of PKC δ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes.
The Laminin-Induced Phosphorylation of PKCδ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes. Cell Mol Neurobiol. 2020 Aug 26;: Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Abstract In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the endfeet that abut the blood vessels of the brain. The asymmetric distribution of this channel is dependent on the function of dystroglycan (DG), a co-expressed laminin receptor, and its associated protein complex. We have demonstrated that the addition of laminin to astrocytes in culture causes the cl...
Source: Cellular and Molecular Neurobiology - August 25, 2020 Category: Cytology Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Tags: Cell Mol Neurobiol Source Type: research

Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in A β25-35-induced Alzheimer's disease models in vitro.
CONCLUSIONS: These results suggest that genistein exerts a neuroprotective effect on SH-SY5Y cells in vitro via Nrf2/HO-1/PI3K signaling, providing a foundation for the application of genistein in the treatment of neurodegenerative diseases related to Nrf2/HO-1/PI3K signaling. PMID: 33605427 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - February 21, 2021 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research

Deoxycholic acid induces proinflammatory cytokine production by model oesophageal cells via lipid rafts
J Steroid Biochem Mol Biol. 2021 Aug 23:105987. doi: 10.1016/j.jsbmb.2021.105987. Online ahead of print.ABSTRACTThe bile acid component of gastric refluxate has been implicated in inflammation of the oesophagus including conditions such as gastro-oesophageal reflux disease (GORD) and Barrett's Oesophagus (BO). Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MAP kinase, tyrosine...
Source: Mol Biol Cell - August 26, 2021 Category: Molecular Biology Authors: Francis Quilty Michael Freeley Siobhan Gargan John Gilmer Aideen Long Source Type: research

Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Cell. 2022 Apr 29:S0092-8674(22)00443-3. doi: 10.1016/j.cell.2022.04.005. Online ahead of print.ABSTRACTEpidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, binds to cannabinoid receptor 1 (CB1/CNR1) in the vasculature and is implicated in CVD. A UK Biobank analysis found that cannabis was an risk factor for CVD. We found that marijuana smoking activated inflammatory cytokines implicated in CVD. In silico virtual screening identified genistein, a soybean iso...
Source: Atherosclerosis - April 30, 2022 Category: Cardiology Authors: Tzu-Tang Wei Mark Chandy Masataka Nishiga Angela Zhang Kaavya Krishna Kumar Dilip Thomas Amit Manhas Siyeon Rhee Johanne Marie Justesen Ian Y Chen Hung-Ta Wo Saereh Khanamiri Johnson Y Yang Frederick J Seidl Noah Z Burns Chun Liu Nazish Sayed Jiun-Jie Shi Source Type: research

Associations between isoflavone exposure and reproductive damage in adult males: evidence from human and model system studies
This study was designed to investigate whether isoflavone exposure during adulthood could have deleterious impacts on male reproductive health by the cross-sectional study, animal experiments, and in vitro tests. In the cross-sectional study, we observed that urinary isoflavones were not significantly associated with semen quality including sperm concentrations, sperm count, progressive motility, and total motility, respectively (All P-value for trend>0.05). However, negative associations were found between plasma testosterone and urinary Σisoflavones, genistein, glycitein, and dihydrodaidzein (all P-value for trend &l...
Source: Biology of Reproduction - August 10, 2022 Category: Reproduction Medicine Authors: Wang Yang Jiuyang Deng Jianfang Gao Huan Yang Qing Chen Zhou Niya Xi Ling Guowei Zhang Peng Zou Lei Sun Linping Huang Jinyi Liu Jia Cao Lin Ao Source Type: research