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Nutrition: Potassium
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Total 74 results found since Jan 2013.
Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis
In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.PMID:37034221 | PMC:PMC10077030
Source: Cancer Control - April 10, 2023 Category: Cancer & Oncology Authors: Huiqin Bian Yu Gu Chen Chen Jinnan Chen Fei Zhang Zhonghai Xu Qian Wang Rui Mi Xuan Wu Yaojuan Lu Qiping Zheng Junxia Gu Source Type: research
Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF- κB signaling pathway
In conclusion, Kv1.3 may be an indispensable membrane protein in ox-LDL-induced RAW264.7 macrophage inflammation in atherosclerosis through the ERK/NF-κB pathway.PMID:36100082 | DOI:10.1016/j.abb.2022.109394
Source: Atherosclerosis - September 13, 2022 Category: Cardiology Authors: Qiujie Zhang Lin Liu Yanyan Hu Lin Shen Li Li Yuanyuan Wang Source Type: research
Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether ‐à‐go‐go–Related Gene and Cav1.2
Conclusion: Chronic incubation with FLV and LPV produced more severe channel-blocking effects and contributed to altered channel gating and shortened action potential duration by inhibiting hERG and Cav1.2.
Source: Frontiers in Pharmacology - July 7, 2022 Category: Drugs & Pharmacology Source Type: research
Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium
Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the mechanism of KCa3.1 membrane targeting is poorly understood. We previously reported that targeting of KCa3.1 to the BLM of epithelial cells is Myosin-Vc-, Rab1-and Rab8-dependent. Here, we examine the role of the SNARE proteins VAMP3, SNAP-23 and syntaxin 4 (STX-4) in the targeting of KCa3.1 to the BLM of Fischer rat thyroid (FRT) epithelial cells. We carried out immunoblot, siRN...
Source: Frontiers in Physiology - June 27, 2022 Category: Physiology Source Type: research
SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons
CONCLUSION: SUMOylation of the Kir7.1 in the spinal cord might contribute to the development of SNI-induced mechanical allodynia by decreasing the Kir7.1 surface expression in rats.PMID:35633059 | DOI:10.1111/cns.13871
Source: CNS Neuroscience and Therapeutics - May 28, 2022 Category: Neuroscience Authors: You-You Lv Han Wang Hai-Ting Fan Ting Xu Wen-Jun Xin Rui-Xian Guo Source Type: research
NEK7-Mediated Activation of NLRP3 Inflammasome Is Coordinated by Potassium Efflux/Syk/JNK Signaling During Staphylococcus aureus Infection
This study expands our understanding of the basic molecular mechanism regulating inflammation and provides potential value for anti-infective drug development against S. aureus infection.
Source: Frontiers in Immunology - September 16, 2021 Category: Allergy & Immunology Source Type: research
Hypoxic and osmotic expression of Kir2.1 potassium channels in retinal pigment epithelial cells: Contribution to vascular endothelial growth factor expression
Exp Eye Res. 2021 Aug 20:108741. doi: 10.1016/j.exer.2021.108741. Online ahead of print.ABSTRACTRetinal pigment epithelial (RPE) cells express different subtypes of inwardly rectifying potassium (Kir) channels. We investigated whether human and rat RPE cells express genes of strongly rectifying Kir2 channels. We also determined the hypoxic and hyperosmotic regulation of Kir2.1 gene expression in cultured human RPE cells and the effects of siRNA-mediated knockdown of Kir2.1 on VEGFA expression, VEGF secretion, proliferation, and viability of the cells. Extracellular hyperosmolarity was induced by addition of NaCl or sucrose...
Source: Experimental Eye Research - August 23, 2021 Category: Opthalmology Authors: Eva Klose Heidrun Kuhrt Leon Kohen Peter Wiedemann Andreas Bringmann Margrit Hollborn Source Type: research
KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of VTA neurons by ethanol
CONCLUSIONS: KCNK13 plays an important role in ethanol stimulation of rat VTA neurons, and KCNK13 is dynamically regulated by cell damage, by ethanol exposure, and during withdrawal. KCNK13 is a novel alcohol-sensitive protein and further investigation of this channel may offer new avenues for the development of agents useful in altering the rewarding effect of alcohol.PMID:33960499 | DOI:10.1111/acer.14630
Source: Alcoholism, Clinical and Experimental Research - May 7, 2021 Category: Addiction Authors: Chang You Bertha J Vandegrift Mark S Brodie Source Type: research
